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The Nephropathy of Acute Choline Deficiency in Germfree, Conventionalized and Open Animal Room Rats

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Germ-Free Biology Experimental and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

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Abstract

Weanling rats fed diets deficient in choline develop fatty livers promptly and bilateral renal cortical hemorrhagic necrosis within a period of 6–8 days. Impairment of the mobilization of fat from the liver because of the low availability of methyl donor compounds appears to be the cause of the liver fat accumulation. The mechanism of the development of the nephropathy is poorly understood.

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References

  1. Salmon, W., and P. Newberne 1962 Effect of antibiotics, sulfonamides and a nitrofuran on development of hepatic cirrhosis in choline deficient rats. J. Nutrition 76:483.

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  2. Levenson, S. M., A. L. Nagler, E. F. Geever, and E. Seifter 1968 Acute choline deficiency in germfree, conventionalized and open animal room rats: Effects of neomycin, Chlortetracycline, vitamin B12 and coprophagy prevention. J. Nutrition 95: 1.

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  3. Nagler, A. L., W-D. Dettbarn, E. Seifter and S. M. Levenson 1968 Tissue levels of acetylcholine and acetylcholinesterase in weanling rats subjected to acute choline deficiency. J. Nutrition 94: 13.

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  4. Nagler, A. L., W-D. Dettbarn and S. M. Levenson 1968 Tissue levels of acetylcholine and acetylcholinesterase in weanling germfree rats subjected to acute choline deficiency. J. Nutrition (In press).

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  5. Levenson, S.M., D. Kan, M. Lev and F. S. Daft 1968 Influence of microorganisms on mammalian metabolism and nutrition with specific reference to oxygen consumption, carbondioxide production and colonic temperatures. J. Nutrition (In press).

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  6. Levenson, S. M., D. Kan, E. Kwong, and R. H. Barnes 1968 Choline biosynthesis in germfree rats. J. Nutrition (In press).

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  7. Nagler, A. L., S. M. Levenson and S. Baez 1968 Microcirculation in acute choline deficiency. Fed. Proc. 27

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  8. Baez, S., and H. Gordon 1957 Microvascular refractoriness to epinephrine in germfree rats. Symposium on Gnotobiotic Research June 11–13, 1967, Park Motor Inn, Madison, Wisconsin.

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Author information

Authors and Affiliations

  1. Departments of Surgery, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

    Arnold L. Nagler, Eli Seifter, Erving F. Geever & Stanley M. Levenson

  2. Departments of Pathology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

    Arnold L. Nagler & Erving F. Geever

  3. Departments of Biochemistry, College of Physicians and Surgeons, Columbia University, New York, N.Y.

    Eli Seifter

  4. Albert Einstein College of Medicine, Yeshiva University, USA

    Wolf-D. Dettbarn

  5. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA

    Wolf-D. Dettbarn

Authors
  1. Arnold L. Nagler
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  2. Eli Seifter
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  3. Erving F. Geever
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  4. Wolf-D. Dettbarn
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  5. Stanley M. Levenson
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1969 Springer Science+Business Media New York

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Nagler, A.L., Seifter, E., Geever, E.F., Dettbarn, WD., Levenson, S.M. (1969). The Nephropathy of Acute Choline Deficiency in Germfree, Conventionalized and Open Animal Room Rats. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_41

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  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_41

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

  • eBook Packages: Springer Book Archive

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