Development of Immunologic Competence in Germfree and Conventional Mice

  • M. J. Bosma
Part of the Advances in Experimental Medicine and Biology book series (AEMB)


The ability of an animal to resist the vast variety and multitude of disease-causing pathogens is primarily a function of its immune potential. How this immune potential is programmed with specificity against so many prospective immunogens is one of the great mysteries of immunology.


Spleen Cell Conventional Mouse Spleen Mass Immunologic Competence Germfree Mouse 
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  1. 1.
    Bosma, M. J., Makinodan, T. and Walburg, H. E., Jr., J. Immunol., 99: 420, 1967.PubMedGoogle Scholar
  2. 2.
    Brown, R. A., Albright, J. F. and Makinodan, T. Nature (Lond.), 210: 1383, 1966.CrossRefGoogle Scholar
  3. 3.
    Gustafsson, B. E. and Laurell, G. B. J. Exp. Med., 110: 675, 1959.CrossRefGoogle Scholar
  4. 4.
    Sell, S. J. Immunol., 93: 81 and 122, 1964.PubMedGoogle Scholar
  5. 5.
    Miyakawa, M. Ann. N. Y. Acad. Sci., 78: 221, 1959.PubMedCrossRefGoogle Scholar
  6. 6.
    Bauer, H. et al. J.A.M.A., 187: 715, 1964.PubMedCrossRefGoogle Scholar
  7. 7.
    Wostmann, B. S. and Olson, G. B. J. Immunol., 92: 41, 1964.PubMedGoogle Scholar
  8. 8.
    Horowitz, R. E. et al. Amer. J. Pathol., 44: 747, 1964.Google Scholar
  9. 9.
    Olson, G. B. and Wostmann, B. S. J. Immunol., 97: 267 and 275, 1966.PubMedGoogle Scholar
  10. 10.
    Makinodan, T. et al. Med. Clin. N. Amer., 49; 1569, 1965.PubMedGoogle Scholar
  11. 11.
    Mark, R. and Dixon, F. J. J. Immunol., 91: 614, 1963.PubMedGoogle Scholar
  12. 12.
    Albright, J. F. and Makinodan, T. J. Cell Physiol., 67 (suppl): 185, 1966.PubMedCrossRefGoogle Scholar
  13. 13.
    Fishman, M. and Adler, F. L. Cold Spring Harbor Symposium on Quantitative Biology, XXXII: 343, 1967.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1969

Authors and Affiliations

  • M. J. Bosma
    • 1
  1. 1.The Institute for Cancer ResearchPhiladelphiaUSA

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