Leukemia in Germfree AKR Mice
Mice of the AKR strain have a very high incidence of lymphocytic neoplasms which appear to be caused by a vertically transmitted virus (see reviews by Kaplan, 1967; Moloney, 1962; Furth et al., 1964; Gross, 1958 and 1961). Since this agent is vertically transmitted, it is expected that germfree mice would also develop leukemia, unless the presence of a microbial flora, or other horizontally transmitted viruses, contribute to its development. That this is indeed the case has been demonstrated by Pollard and his co-workers (Pollard et al., 1966; Pollard, 1967) who showed that germfree AKR mice do develop leukemia in high incidence. The purpose of this paper is to compare the incidence of leukemia in germfree AKR mice with their conventional counterparts. We will also describe some of the characteristics of the germfree AKR mouse which make it somewhat different from other germfree inbred strains.
KeywordsPercent Survivor Anal Area Conventional Mouse Conventional Animal Leukemia Development
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