Nucleoproteins

  • A. R. Peacocke
  • R. B. Drysdale

Abstract

The structure of nucleoproteins1–5 is of importance because, in the cell nucleus, DNA is almost completely complexed with protein and the transference of genetic information from the DNA to RNA, and hence to the synthetic mechanisms, is likely to be profoundly modified by the presence of the protein. The existence of this complex in a stable form appears to be essential to the structure of the chromosome since agents which dissociate the complex also disrupt the structure of the chromosome. After the early interest in the protein component, attention was largely directed to the DNA, but, in recent years, the nuclear proteins and the nature of their complex with DNA have again been the subject of study. The nature of the interaction of the RNA-protein complex of ribosomes is largely unknown.

Keywords

Phosphorus Hydrate Sodium Chloride Lysine Polypeptide 

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References

  1. 1.
    Davison, P. F., Conway, B. E. and Butler, J. A. V. Progr. Biophys., 1954, 4, 148Google Scholar
  2. 2.
    Magasanik, B. The Nucleic Acids, (Ed. Chargaffand Davidson), Vol. 1, p. 373. New York; Academic Press, 1955Google Scholar
  3. 3.
    Felix, K., Fischer, H. and Krekels, A. Progr. Biophys., 1956, 6, 1Google Scholar
  4. 4.
    Ambrose, E. J. Progr. Biophys., 1956, 6, 25Google Scholar
  5. 5.
    Peacocke, A. R. Progr. Biophys., 1960, 10, 55PubMedGoogle Scholar
  6. 6.
    Feughelman, M., Langridge, R., Seeds, W. E., Stokes, A. R., Wilson, H. R., Hooper, C. W., Wilkins, M. H. F., Barclay, R. K. and Hamilton, L. D. Nature, Lond., 1955, 175, 834CrossRefGoogle Scholar
  7. 7.
    Dounce, A. L. The Nucleic Acids, (Ed. Chargaffand Davidson), Vol. 2, p. 93. New York; Academic Press, 1955Google Scholar
  8. 8.
    Alexander, P. Nature, Lond., 1952, 169, 226CrossRefGoogle Scholar
  9. 9.
    Astbury, W. T. Symp. Soc. exp. Biol, 1947, 1, 66PubMedGoogle Scholar
  10. 10.
    Wilkins, M. H. F. Cold Spr. Harb. Symp. quant. Biol, 1956, 21, 75; Biochem. Soc. Symp., 1956, 14, 13CrossRefGoogle Scholar
  11. 11.
    Cruft, H. J., Hindley, J., Mauritgen, C. M. and Stedman, E. Nature, Lond., 1957, 180, 1107; Luck, J. M., Cook, H. A., Eldridge, N. T., Haley, M. I., Kuphe, W. D. and Rasmussel, P. S. Arch. Biochem., 1956, 65, 449; Phillips, D. M. P., Progr. Biophys., 1962, 12, 211CrossRefGoogle Scholar
  12. 12.
    Bradbury, E. M., Price, W. C., Wilkinson, G. R. and Zubay, G. J. mol. Biol., 1962, 4, 50PubMedCrossRefGoogle Scholar
  13. 13.
    Zubay, G. and Wilkins, M. H. F. J. mol. Biol., 1962, 4, 444CrossRefGoogle Scholar
  14. 14.
    Wilkins, M. H. F., Zubay, G. and Wilson, H. R. J. mol Biol, 1959, 1, 179CrossRefGoogle Scholar
  15. 15.
    Doty, P. and Zubay, G. J. Amer. chem. Soc, 1956, 78, 6707Google Scholar
  16. 16.
    Peacocke, A. R. and Preston, B. N. Nature, Lond, 1961, 192, 228; Murray, K. and Peacocke, A. R. Biochem. biophys. Acta, 1962, 55, 935; Bayley, P. M., Preston, D. N. and Peacocke, A. R. Biochim. biophys. Acta, 1962, 55, 943; Giannoni, G. and Peacocke, A. R. Biochim. biophys. Acta, 1963, 68, 157; Lee, M. F., Walker, I. O. and Peacocke, A. R. Biochim. biophys. Acta, 1963, 72, 310; Giannoni, G., Peacocke, A. R. and Walker, I. O. Biochim. biophys. Acta, 1963, 72, 469CrossRefGoogle Scholar
  17. 17.
    Dounce, A. L. and O’Connell, M. J. Amer. chem. Soc, 1958, 80, 2013; Kirby, K. S. Molecular Basis of Neoplasma, p. 59. Austin: University of Texas Press, 1962; Kirby, K. S. Progress in experimental Tumour Research, (Ed. Hornberger), Vol. 2, p. 291. Basel; Kargar, 1961; Leveson, J. E. and Peacocke, A. R. Biochim. biophys. Acta. 1966, 123, 329CrossRefGoogle Scholar
  18. 18.
    Crick, F. H. C. and Watson, D. Nature, Lond., 1956, 177, 473CrossRefGoogle Scholar
  19. 19.
    Brenner, S., Streisinger, G., Moine, R. W., Champe, S. P., Barnett, L., Berger, S. and Rees, M. W. J. mol. Biol, 1959, 1, 281CrossRefGoogle Scholar
  20. 20.
    Cold Spr. Harb. Symp. quant. Biol, 1953, 17; The Nature of Viruses, Ciba Foundation Symp. Churchill; London, 1956; Gierer, A. Progr. Biophys., 1960, 10, 299; The Viruses, (Ed. Burnet and Stanley). New York; Academic Press, 1959Google Scholar
  21. 20a.
    Blake, A. and Peacocke, A. R., Nature, Lond., 1965, 208, 1319CrossRefGoogle Scholar
  22. 21.
    Klug, A. and Caspar, D. L. D. Adv. Virus Res., 1960, 7, 225; Klug, A., Holmes, K. C. and Finch, J. T. Unpublished observations, 1960PubMedCrossRefGoogle Scholar
  23. 22.
    Klug, A. and Franklin, R. E. Biochim. biophys. Acta, 1957, 23, 199PubMedCrossRefGoogle Scholar
  24. 23.
    Franklin, R. E., Caspar, D. L. D. and Klug, A. Plant Pathology: Problems and Progress, (Ed. Holton), p. 447. University Press; Wisconsin, 1959Google Scholar
  25. 24.
    Markham, R. Disc. Faraday Soc, 1951, 11, 221CrossRefGoogle Scholar
  26. 25.
    Caspar, D. L. D. Nature, Lond., 1956, 177, 475CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1965

Authors and Affiliations

  • A. R. Peacocke
    • 1
  • R. B. Drysdale
    • 2
  1. 1.St. Peter’s CollegeOxfordUK
  2. 2.the University of BirminghamUK

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