The Glial Fibrillary Acidic Protein and Astrocytic 10-Nanometer Filaments

  • Doris Dahl
  • Amico Bignami

Abstract

Cytoplasmic filaments of indefinite length and approximately 10 nm in diameter are present in many eucaryotic cells. They are called intermediate filaments (IFs) because they are intermediate in diameter between microtubules (20–26 nm) and actin microfilaments (5–6 nm). The IFs are major structural components of neural tissue, where they form bundles called neurofibrils and glial fibrils at the light microscopy level. Astroglial cells accumulate filaments as a basic reaction to injury (fibrous gliosis), and the same is true for neurons under certain pathological conditions including Alzheimer’s senile dementia (neurofibrillary tangles).

Keywords

Glial Fibrillary Acidic Protein Cyanogen Bromide Immunoaffinity Chromatography Multiple Sclerosis Plaque Protoplasmic Astrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Doris Dahl
    • 1
    • 2
  • Amico Bignami
    • 1
    • 2
  1. 1.Spinal Cord Injury Research LaboratoryVeterans Administration Medical CenterWest RoxburyUSA
  2. 2.Department of NeuropathologyHarvard Medical SchoolBostonUSA

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