Abstract
Although the dependence of the mammalian brain, under normal conditions, on a regulär supply of glucose from the bloodstream has been acknowledged for 50 years or more, ways by which glucose passes to the brain and how it travels within the brain were ignored until relatively recently. Even though efforts were devoted to movement of glucose to the brain overall in the middle 1960s, any curiosity about transport of the sugar through the constituent cellular compartments began to emerge only within the last decade. Thus, in reviews of 20 years ago,1,2 the tacit assumption was that the glucose got into the brain by passive diffusion: there seems to have been no reported research that gave evidence of any carrier-mediated mechanism, though the possibility had been suggested.3
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References
Geiger, A., 1962, Neurochemistry (K. A. C. Elliott, I. H. Page, and J. H. Quastel, eds.), Charles C Thomas, Springfield, Illinois, pp. 128–149.
Mcllwain, H., 1966, Biochemistry and the Central Nervous System, 3rd ed., Churchill, London.
Johnstone, R. M., and Scholefield, P. G., 1962, Neurochemistry (K. A. C. Elliott, I. H. Page, and J. H. Quastel, eds.), Charles C Thomas, Springfield, Illinois, pp. 376–398.
Fishman, R. A., 1964, Am. J. Physiol. 206: 836–844.
Crone, C., 1960, Acta Physiol. Scand. [Suppl.] 175:33–34.
Crone, C., 1965, J. Physiol. (Lond.) 181:103–113.
Anthonisen, P., and Crone, C., 1956, Acta Physiol. Scand. 37: 370–379.
LeFevre, P. G., and Peters, A. A., 1966, J. Neurochem. 13: 35–46.
Eidelberg, E., Fishman, J., and Harns, M. L., 1967, J. Physiol. (Lond.) 191: 47–57.
Bidder, T. G., 1968, J. Neurochem. 15: 867–874.
Himsworth, R. L., 1968, J. Physiol. (Lond.) 198: 467–477.
Joanny, P., Corriol, P., and Hillman, H., 1969, Biochem. J. 112: 367–371.
Bachelard, H. S., 1971, J. Neurochem. 13: 213–222.
Gilboe, D. D., and Betz, A. L., 1970, Am. J. Physiol. 219: 774–778.
Buschiazzo, P. M., Terrell, E. B. and Regen, D. M., 1970, Am. J. Physiol. 219: 1505–1513.
Cutler, R. W. P., and Sipe, J. C., 1971, Am. J. Physiol. 220: 1182–1186.
Bachelard, H. S., Daniel, P. M., Love, E. R., and Pratt, O. E., 1972, J. Physiol. (Lond.) 222: 149–150 P.
Bachelard, H. S., 1971, Brain Hypoxia (J. B. Brierley and B. S. Meldrum, eds.), Heinemann, London, pp. 251–260.
Bachelard, H. S., 1975, Brain Work (D. H. Ingvar and N. A. Lassen, eds.), Munksgaard, Copenhagen, pp. 126–141.
Crone, C., 1971, Ion Homeostasis of the Brain (B. K. Siesjö and S. C. S0rensen, eds.), Munksgaard, Copenhagen, pp. 52–62.
Crone, C., 1975, Brain Work (D. H. Ingvar and N. A. Lassen, eds.), Munksgaard, Copenhagen, pp. 142–143.
Bradbury, M., 1979, The Concept of a Blood-Brain Barrier, Wiley, Chichester.
Dempsey, E. W., 1958, Biology of Neuroglia (W. F. Windle, ed.), Charles C Thomas, Springfield, Illinois, p. 41.
Cohen, M. W., Gershenfeld, H. M., and Kuffler, S. W., 1968, J. Physiol. (Lond.) 197: 363–380.
Newburgh, R. W., and Rosenberg, R. W., 1972, Proc. Natl. Acad. Sei. U.S.A. 69: 1677–1680.
Yudilevich, D. L., 1970, Capillary Permeability (C. Crone and N. Lassen, eds.), Munksgaard, Copenhagen, pp. 115–129.
Sokoloff, L., Reivich, M., Kennedy, C., DesRosiers, M. H., Patlak, C. S., Pettigrew, O., Sakurada, O., and Shinohara, M., 1977, J. Neurochem. 28: 897–916.
Sokoloff, L., 1979, Acta Neurol. Scand. [Suppl.] 60: 640–649.
Crane, P. D., Braun, L. D., Cornford, E. M., Cremer, J. E., Glass, J. M., and Oldendorf, W. H., 1978, Strohe 9: 12–18.
Crane, P. D., Pardridge, W. M., Braun, L. D., Nyerges, A. M., and Oldendorf, W. H., 1981, J. Neurochem. 36: 1601–1604.
Ginsberg, M. D., and Reivich, M., 1979, Acta Neurol. Scand. [Suppl.] 60: 226–227.
Welsh, F. A., Greenberg, J. H., James, S. C., Ginsberg, M. D., and Reivich, M., 1979, Acta Neurol. Scand. [Suppl.] 60: 270–271.
Thurston, J. N., Pollack, P. G., and Warren, S. K., 1970, J. Clin. Invest. 49: 2139–2145.
Haymond, M. W., Karl, I. E., Keating, J. P., and de Vivo, D. C., 1978, Ann. Neurol. 3: 207–215.
Bachelard, H. S., 1974, Brain Biochemistry, Ist ed., Chapman and Hall, London, p. 51.
Gjedde, A., and Crone, C., 1975, Am. J. Physiol. 225: 1165–1169.
Crone, C., 1980, Microvasc. Res. 20: 133–149.
Gjedde, A., and Rasmussen, M., 1980, J. Neurochem. 35: 1375–1381.
Oldendorf, W. H., 1970, Brain Res. 24: 112–116.
Oldendorf, W. H., 1971, Am. J. Physiol. 221: 1629–1639.
Pardridge, W. M., and Oldendorf, W. H., 1975, Biochim. Biophys. Acta 382: 377–392.
Pardridge, W. M., and Oldendorf, W. H., 1977, J. Neurochem. 28: 5–12.
Daniel, P. M., Donaldson, J., and Pratt, O. E., 1974, J. Physiol. {Lond.) 237: 8–9 P.
Daniel, P. M., Donaldson, J., and Pratt, O. E., 1975, Med. Biol. Eng. 13: 214–227.
Bachelard, H. S., Daniel, P. M., Love, E. R., and Pratt, O. E., 1973, Proc. R. Soc Lond. [Biol.] 183: 71–82.
Gilboe, D. D., and Betz, A. L., 1970, Am. J. Physiol. 219: 774–779.
Gilboe, D. D., Betz, A. L., and Langebartel, D. A., 1973, J. Appl. Physiol. 34: 534–537.
Drewes, L. R., and Gilboe, D. D., 1973, J. Biol. Chem. 218: 2489–2496.
Mcllwain, H., and Bachelard, H. S., 1971, Biochemistry and the Central Nervous System, 4th ed., Churchill, London.
Bachelard, H. S., Campbell, W. J., and Mcllwain, H., 1962, Biochem. J. 84: 225–232.
Lund-Andersen, H., 1979, Physiol. Rev. 59: 305–352.
Bachelard, H. S., 1980, Cerebral Metabolism and Neural Function (J. V. Passonneau, R. A. Hawkins, W. D. Lust, and F. A. Welsh, eds.), Williams and Wilkins, Baltimore, pp. 106–119.
Bachelard, H. S., 1982, Chemisms of the Brain (R. Rodnight, H. S. Bachelard, and W. L. Stahl, eds.), Churchill, London, pp. 3–11.
Lust, W. D., Schwartz, J. P., and Passonneau, J. V., 1975, Mol. Cell Biochem. 8: 169–176.
Edström, A., Kanje, M., and Walum, E., 1975, J. Neurochem. 24: 395–401.
Walum, E., and Edström, A., 1976, Exp. Cell Res. 97: 15–22.
Walum, E., and Edström, A., 1976, Exp. Cell Res. 100: 111–116.
Cummins, C. J., Glover, R. A., and Sellinger, O. Z., 1979, J. Neurochem. 33: 779–785.
Keller, K., Lange, K., and Noske, W., 1981, J. Neurochem. 36: 1012–1017.
Diamond, I., and Fishman, R. A., 1973, J. Neurochem. 20: 1533–1542.
Heaton, G. M., and Bachelard, H. S., 1973, J. Neurochem. 21: 1099–1108.
Eilam, Y., and Stein, W. D., 1974, Methods Membr. Biol. 2: 283–354.
Taylor, L. P., and Holman, G. D., 1981, Biochim. Biophys. Acta 642: 325–335.
Betz, A. L., Gilboe, D. D., Yudilevich, D. L., and Drewes, L. R., 1973, Am. J. Physiol. 225: 586–592.
Atkinson, A. J., and Weiss, M. F., 1969, Am. J. Physiol. 216: 1120–1126.
Fletcher, A. M., and Bachelard, H. S., 1978, J. Neurochem. 31: 233–238.
Betz, A. L., Cjetsey, J., and Goldstein, G. W., 1979, Am. J. Physiol. 236: C96 - C102.
Crone, C., and Thompson, A. M., 1970, Capillary Permeability (C. Crone and N. Lassen, eds.), Munksgaard, Copenhagen, pp. 446–455.
Gjedde, A., 1981, J. Neurochem. 36: 1463–1471.
Daniel, P. M., Love, E. R., and Pratt, O. E., 1980, J. Physiol. (Lond.) 305: 44P - 45 P.
Havrankova, J., Roth, J., and Brownstein, M., 1978, Nature 272: 827–829.
Margolis, R. U., and Altszuler, N., 1967, Nature 215: 1375–1376.
Owen, O. E., Reichard, G. A., Boden, G., and Schuman, C., 1974, Metab. Clin. Exp. 23: 7–13.
Gottstein, U., 1975, Brain Work (D. H. Ingvar and N. A. Lassen, eds.), Munksgaard, Copenhagen, pp. 144–148.
Butterfield, W. J. H., Adams, M. E., Seils, R. A., Sterky, G., and Whichelow, M. J., 1966, Lancet 1: 557–558.
Rafaelson, O. J., 1961, Metabolism 10: 99–105.
Nelson, S. R., Schulz, D. W., Passonneau, J. V., and Lowry, O. H., 1968, J. Neurochem. 15: 1271–1279.
Mellerup, E. T., and Rafaelson, O. J., 1969, J. Neurochem. 16: 777–783.
Strang, R. H. C., and Bachelard, H. S., 1971, J. Neurochem. 18: 1799–1807.
Daniel, P. M., Love, E. R., and Pratt, O. E., 1977, Proc. R. Soc. Lond. [Biol.] 196: 85–104.
Strang, R. H. C., and Bachelard, H. S., 1973, J. Neurochem. 20: 987–993.
Gjedde, A., and Rasmussen, M., 1980, J. Neurochem. 35: 1375–1381.
Phillips, M. E., and Coxon, R. V., 1976, J. Neurochem. 27: 643–645.
Crockett, M. E., Daniel, P. M., Love, E. R., Moorhouse, S. R., and Pratt, O. E., 1977, J. Physiol. (Lond.) 271: 24P - 26 P.
Betz, A. L., Gilboe, D. D., and Drewes, L. R., 1974, Brain Res. 67: 307–316.
Drewes, L. R., Gilboe, D. D., and Betz, A. L., 1973, Arch. Neurol. 29: 385–390.
Kleihues, P., 1973, Arch. Neurol. 29: 390.
Meldrum, B. S., and Horton, R. W., 1973, Electroencephalogr. Clin. Neurophysiol. 35: 59–66.
Horton, R. W., Meldrum, B. S., and Bachelard, H. S., 1973, J. Neurochem. 21: 507–520.
Diamond, I., and Fishman, R. A., 1973, Brain Res. 57: 239–245.
Krebs, H. A., 1961, Biochem. J. 80: 225–231.
Klee, G. B., and Sokoloff, L., 1967, J. Biol. Chem. 242: 3880–3883.
Owen, O. E., Morgan, A. O., Kemp, H. G., Sullivan, J. M., Herrera, M. G., and Cahill, G. F., 1967, J. Clin, luvest. 46: 1589–2595.
Hawkins, R. A., Williamson, D. H., and Krebs, H. A., 1971, Biochem. J. 122: 13–18.
Daniel, P. M., Love, E. R., Moorehouse, S. R., Pratt, O. E., and Wilson, P., 1971, Lancet 2: 637–638.
Itoh, T., and Quastel, J. H., 1970, Biochem. J. 116: 641–655.
Daniel, P. M., Love, E. R., Moorehouse, S. R., and Pratt, O. E., 1977, J. Neurol. Sei. 34: 1–13.
Daniel, P. M., Love, E. R., Moorehouse, S. R., Pratt, O. E., and Wilson, P., 1972, J. Physiol. (Lond.) 221: 22P - 23 P.
Oldendorf, W. H., 1973, Am. J. Physiol. 224: 1450–1453.
Cremer, J. E., Teal, H. M., and Cunningham, V. J., 1982, J. Neurochem. 39: 674–677.
Cremer, J. E., Braun, I.D., and Oldendorf, W. H., 1976, Biochim. Biophys. Acta 448: 633–637.
Gaitonde, M. K., and Richter, D., 1966, J. Neurochem. 13: 1309–1318.
Daniel, P. M., Love, E. R., and Pratt, O. E., 1978, J. Physiol. (Lond.) 274: 141–148.
Moore, T. J., Lione, A. P., and Regen, D. M., 1973, Am. J. Physiol. 225: 925–929.
Bachelard, H. S., 1980, Multidisciplinary Approach to Brain Development (C. DiBenedetta, R. Balazs, G. Gombos, and G. Porcellati, eds.), Elsevier, Amsterdam, pp. 3–14.
Moore, T. J., Lione, A. P., Sugden, M. C., and Regen, D. M., 1976, Am. J. Physiol. 230: 619–630.
Diem, K., and Lentner, C. (eds.), 1975, Documenta Geigy, 7th ed., Geigy, Macclesfield, p. 608.
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Bachelard, H.S. (1983). Transport of Hexoses and Monocarboxylic Acids. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4555-6_16
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DOI: https://doi.org/10.1007/978-1-4899-4555-6_16
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