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Amino Acid Transport

  • Chapter
Handbook of Neurochemistry

Abstract

The purpose of the present chapter is to update knowledge of the mechanisms and significance of the cellular transport of amino acids in neural tissue. In the first edition of Handbook of Neurochemistry, Cohen and Lajtha1 extensively reviewed the data on amino acid transport in the brain accumulated up to the beginning of the 1970s. We thus now concentrate on developments since then, the scope being narrowed to transmembrane movements of amino acids in vitro. Capillary transport in vivo is dealt with by other authors in this volume. For the same reason, neurotransmitter amino acids are discussed only insofar as is pertinent to cellular transport in general. In particular, the depolarization-induced release of transmitter amino acids (possibly by exocytosis) is not in-cluded. Transport phenomena at the synapse level have for their part been reviewed not too long ago.2–5 Certain methodological aspects are critically evaluated, but for all detailed methodological discussion, we refer to Bradford 6 and Oja and Vahvelainen.7

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Tampere, SF-33101, Tampere 10, Finland

    S. S. Oja

  2. Adult Psychiatry Branch, National Institute of Mental Health, St. Elizabeth’s Hospital, Washington, D.C., 20032, USA

    E. R. Korpi

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  1. S. S. Oja
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  1. Center for Neurochemistry, Wards Island, New York, USA

    Abel Lajtha

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Oja, S.S., Korpi, E.R. (1983). Amino Acid Transport. In: Lajtha, A. (eds) Handbook of Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4555-6_15

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