Familial predisposition to lung cancer
There can be little doubt that lung cancer is the product of environmental exposures, primarily tobacco but also radioactive ores, heavy metals and petrochemicals. However, the idea that individuals differ in their response to these environmental exposures is at least 30 years old. Recognizing that cigarette smoking was the principal cause of lung cancer, Goodhart  noted:’ ... different individuals show wide variation in the type and strength of stimulus needed for a neoplastic reaction so that, although even quite light smokers run a significantly higher risk of lung cancer than non-smokers, nine out of ten of the heaviest smokers never get it at all. Personal idiosyncrasy seems to be an important factor in carcinogenesis and this suggests the hypothesis that the population may be genetically heterogeneous for susceptibility to cancer, some individuals being more ‘cancer-prone’ than others.
KeywordsChrome Adenocarcinoma Adduct Stratification Smoke
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