Familial predisposition to lung cancer

  • Thomas A. Sellers


There can be little doubt that lung cancer is the product of environmental exposures, primarily tobacco but also radioactive ores, heavy metals and petrochemicals. However, the idea that individuals differ in their response to these environmental exposures is at least 30 years old. Recognizing that cigarette smoking was the principal cause of lung cancer, Goodhart [1] noted:’ ... different individuals show wide variation in the type and strength of stimulus needed for a neoplastic reaction so that, although even quite light smokers run a significantly higher risk of lung cancer than non-smokers, nine out of ten of the heaviest smokers never get it at all. Personal idiosyncrasy seems to be an important factor in carcinogenesis and this suggests the hypothesis that the population may be genetically heterogeneous for susceptibility to cancer, some individuals being more ‘cancer-prone’ than others.


Lung Cancer Lung Cancer Patient Segregation Analysis Lung Cancer Risk Familial Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Goodhart, C.B. (1959) Cancer-proneness and lung cancer. Practitioner, 182, 578–84.PubMedGoogle Scholar
  2. 2.
    Brisman, R., Baker, R.R., Elkins, R. and Hartmann, W.H. (1967) Carcinoma of the lung in four siblings. Cancer, 20, 2048–53.PubMedCrossRefGoogle Scholar
  3. 3.
    Nagy, I. (1968) Zur Beobachtung von Bronchialkarzinomen bei drei Brüdern. Prax. Pneumol, 22, 718–23.PubMedGoogle Scholar
  4. 4.
    Jones, F.L. Jr (1977) Bronchogenic carcinoma in three siblings. Bull. Geisinger. Med. Cen., 29, 23–5.Google Scholar
  5. 5.
    Goffman, T.E., Hassinger, D.D. and Mulvihill, J.J. (1982) Familial respiratory tract cancer: opportunities for research and prevention. JAMA, 247, 1020–3.PubMedCrossRefGoogle Scholar
  6. 6.
    Joishy, S.K., Cooper, R.A. and Rowley, P.T. (1977) Alveolar cell carcinoma in identical twins: Similarity in time of onset, histochemistry and site of métastases. Ann. Intern. Med., 87, 447–50.PubMedCrossRefGoogle Scholar
  7. 7.
    Paul, S.M., Bacharach, B. and Goepp, C. (1987) A genetic influence on alveolar cell carcinoma. J. Surg. Oncol., 36, 249–53.PubMedCrossRefGoogle Scholar
  8. 8.
    Tokuhata, G.K. and Lilienfeld, A.M. (1963) Familial aggregation of lung cancer in humans. J. Natl Cancer Inst., 30, 289–312.PubMedGoogle Scholar
  9. 9.
    Ooi, W.L., Elston, R.C., Chen, V.W., Bailey-Wilson, J.E. and Rothschild, H. (1986) Increased familial risk for lung cancer. J. Natl Cancer Inst., 76, 217–22.PubMedGoogle Scholar
  10. 10.
    Samet, J.M., Humble, C.G. and Pathak, D.R. (1986) Personal and family history of respiratory disease and lung cancer risk. Annu. Rev. Respir. Dis., 134, 466–70.Google Scholar
  11. 11.
    McDuffie, H.H., Klaassen, DJ. and Dosman, J.A. (1988) Cancer, genes and agriculture, in Principles of Health and Safety in Agriculture, (eds J.A. Dosman and D.W. Cockroft), CRC Press, Boca Raton, FL, pp. 258–61.Google Scholar
  12. 12.
    Shaw, G.L., Falk, R.T., Pickle, L.W., Mason, T.J. and Buffler, P.A. (1991) Lung cancer risk associated with cancer in relatives. J. Clin. Epidemiol, 44, 429–37.PubMedCrossRefGoogle Scholar
  13. 13.
    McDuffie, H.H. (1991) Clustering of cancer in families of patients with primary lung cancer. J. Clin. Epidemiol, 44, 69–76.PubMedCrossRefGoogle Scholar
  14. 14.
    Lynch, H.T., Kimberling, W.J., Markvicka, S.E. et al. (1986) Genetics and smoking-associated cancers: a study of 485 families. Cancer, 57, 1640–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Pierce, R.J., Kune, G.A., Kune, S. et al. (1989) Dietary and alcohol intake, smoking pattern, occupational risk, and family history in lung cancer patients: results of a case-control study in males. Nutr. Cancer, 12, 237–48.PubMedCrossRefGoogle Scholar
  16. 16.
    Sellers, T.A., Ooi, W.L., Elston, R.C., Chen, V.W., Bailey-Wilson, J.E. and Rothschild, H. (1987) Increased familial risk for non-lung cancer among relatives of lung cancer patients. Am. J. Epidemiol, 126, 237–46.PubMedCrossRefGoogle Scholar
  17. 17.
    Wu, A.H., Yu, M.C., Thomas, D.C., Pike, M.C. and Henderson, B.E. (1988) Personal and family history of lung disease as risk factors for adenocarcinoma of the lung. Cancer Res., 48, 7279–84.PubMedGoogle Scholar
  18. 18.
    Osann, K.E. (1991) Lung cancer in women: the importance of smoking, family history of cancer and medical history of respiratory disease. Cancer Res., 51, 4893–7.PubMedGoogle Scholar
  19. 19.
    Sellers, T.A., Elston, R.C., Atwood, L.D. and Rothschild, H. (1992) Lung cancer histologic type and family history of cancer. Cancer, 69, 86–91.PubMedCrossRefGoogle Scholar
  20. 20.
    Ambrosone, C.B., Rao, U., Michalek, A.M., Cummings, K.M. and Mettlin, C.J. (1993) Lung cancer histologic types and family history of cancer. Analysis of histologic subtypes of 872 patients with primary lung cancer. Cancer, 72, 1192–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Horn, D., Courts, F.A., Taylor, R.M. and Solomon, E.S. (1959) Cigarette smoking among high school students. Am. J. Public Health, 49, 1497–511.CrossRefGoogle Scholar
  22. 22.
    Salber, E.J. and MacMahon, B. (1961) Cigarette smoking among high school students related to social class and parental smoking habits. Am. J. Public Health, 51, 1780–9.CrossRefGoogle Scholar
  23. 23.
    Sellers, T.A., Elston, R.C., Stewart, C. and Rothschild, H. (1988) Familial risk of cancer among randomly selected cancer probands. Genet. Epidemiol, 5, 381–91.PubMedCrossRefGoogle Scholar
  24. 24.
    Sellers, T.A., Bailey-Wilson, J.E., Elston, R.C. et al. (1990) Evidence for mendelian inheritance in the pathogenesis of lung cancer. J. Natl Cancer Inst., 82, 1272–9.PubMedCrossRefGoogle Scholar
  25. 25.
    Bonney, G.E. (1986) Regressive logistic models for familial disease and other binary traits. Biometrics, 42, 611–25.PubMedCrossRefGoogle Scholar
  26. 26.
    Doll, R. and Hill, A.B. (1956) Lung cancer and other causes of death in relation to smoking. A second report on the mortality of British doctors. Br. Med. J. Clin. Res., 57, 1071–5.CrossRefGoogle Scholar
  27. 27.
    Sellers, T.A., Potter, J.D., Bailey-Wilson, J.E., Rich, S.S., Rothschild, H. and Elston, R.C. (1992) Lung cancer detection and prevention: evidence for an interaction between smoking and genetic predisposition. Cancer Res., 52. S2694–7.Google Scholar
  28. 28.
    Sellers, T.A., Bailey-Wilson, J.E., Potter, J.D., Rich, S.S., Rothschild, H. and Elston, R.C. (1992) Effect of cohort differences in smoking prevalence on models of lung cancer susceptibility. Genet. Epidemiol., 9, 261–71.PubMedCrossRefGoogle Scholar
  29. 29.
    Amos, C.I., Caporaso, N.E. and Weston, A. (1992) Host factors in lung cancer risk: a review of interdisciplinary studies. Cancer Epidemiol. Biomarkers Prev., 1, 505–13.PubMedGoogle Scholar
  30. 30.
    Shields, P.G. and Harris, C.C. (1993) Genetic predisposition to lung cancer, in Lung Cancer, 1st edn, (eds J.A. Roth, J.D. Cox and W.K. Hong), Blackwell Scientific Publications, Boston, pp. 3–19.Google Scholar
  31. 31.
    Guengerich, F.P. and Shimada, T. (1991) Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol., 4, 391–407.PubMedCrossRefGoogle Scholar
  32. 32.
    Uematsu, F., Kikuchi, H., Motomiya, M. et al. (1991) Association between restriction fragment polymorphism of the human cytochrome p450IIEl gene and susceptibility to lung cancer. Jpn J. Cancer Res., 82 254r–6.CrossRefGoogle Scholar
  33. 33.
    Foiles, P.G., Murphy, S.E., Peterson, L.A., Carmella, S.G. and Hecht, S.S. (1992) DNA and hemoglobin adducts as markers of metabolic activation of tobacco-specific carcinogens. Cancer Res., 52, S2698–701.Google Scholar
  34. 34.
    Harris, C.C. (1989) Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair. Carcinogenesis, 10, 1563–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1996

Authors and Affiliations

  • Thomas A. Sellers

There are no affiliations available

Personalised recommendations