Abstract
A family history of colorectal cancer increases the risk to an individual of developing the disease. This is presumably due to shared environmental factors within families as well as genetic factors. In general, the risk depends upon the extent of the family history with a stronger family history implying a greater risk.
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References
Bishop, D. T. and Thomas, H. J. W. (1990) The genetics of colorectal cancer. Cancer Surv., 9, 585–604.
Morson, B.C., Bussey, H.J.R., Dawy, D.W. et al. (1983) Adenomas of the large bowel. Cancer Surv., 2, 451–77.
Tierney, R.P., Ballantyne, G.H., Modlin, I.M. et al. (1990) The adenoma of carcinoma sequence. Surg. Gynecol. Obstet., 171, 81–94.
Bussey, H.J.R. (1987) Historical developments in familial polyposis coli. Semin. Surg. Oncol., 3, 67–70.
Northover, J.M.A. and Murday, V. (1989) Familial colorectal cancer and familial adenomatous polyposis, in Baillière’s Clinical Gastroenterology: International Practice and Research, Baillière Tindall, London, pp. 593–613.
Bülow, S. (1989) Familial adenomatous polyposis. Ann. Med., 21, 299–307.
Jagelman, D.G., DeCosse, J.J., Bussey, H.J.R. and The Leeds Castle Polyposis Group (1988) Upper gastrointestinal cancer in familial adenomatous polyposis. Lancet, 1, 1149–51.
Klemmer, S., Pascoe, L. and DeCosse, J. (1987) Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am.J.Med.Genet., 28, 385–92.
Burn, J., Chapman, P., Delhanty, J. et al. (1991) The UK Northern Region genetic register for familial adenomatous polyposis coli: use of age of onset, congenital hypertrophy of the retinal pigment epithelium and DNA markers in risk calculations. J.Med.Genet., 28, 289–96.
Hodgson, S.V., Bishop, D.T. and Jay, B. (1994) Genetic heterogeneity of congenital hypertrophy of the retinal pigment epithelium (CHRPE) in families with familial adenomatous polyposis. J. Med. Genet., 31, 55–8.
Northover, J.M. and Murday, V. (1989) Familial colorectal cancer and familial adenomatous polyposis. Baillière’s Clin. Gastroenterol., 3(3), 593–613.
Leppard, B. and Bussey, H.J.R. (1975) Epidermoid cysts, polyposis coli and Gardner’s syndrome. Br. J. Surg., 62, 387–93.
Rustin, R.B., Jagelman, D.G., McGannon, E. et al. (1990) Spontaneous mutation in familial adenomatous polyposis. Dis. Colon Rectum, 33, 52–5.
Jagelamn, D.G. (1987) Extracolonic manifestations of familial polyposis coli. Semin. Surg. Oncol., 3, 88–91.
Bülow, S. (1989) Familial adenomatous polyposis. Ann. Med., 21, 299–307.
Bodmer, W.F., Bailey, C.J., Bodmer, J. et al. (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature, 328, 614–16.
Leppert, M., Dobbs, M., Scambler, P. et al. (1987) The gene for familial polyposis coli maps to the long arm of chromosome 5. Science, 238, 1411–13.
Groden, J., Thliveris, A., Samowitz, W. et al. (1991) Identification and characterization of the familial adenomatous polyposis coli gene. Cell, 66, 589–600.
Kinzler, K.W., Nilbert, M.C., Su, L.-K. et al. (1991) Identification of FAP locus genes from chromosome 5q21. Science, 253, 661–5.
Cottrell, S., Bicknell, D., Kaklamandis, L. et al. (1992) Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas. Lancet, 340, 626–30.
Nishisho, I., Nakamura, Y., Miyoshi, Y. et al. (1991) Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 253, 665–9.
Olschwang, S., Tiret, A., Laurent-Puig, P. et al. (1993) Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients. Cell, 75, 959–68.
Leppert, M., Burt, R., Hughes, J.P. et al. (1990) Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. N. Engt. J. Med., 322, 904–8.
Spirio, L., Otterud, B., Stauffer, D. et al. (1992) Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus. Am. J. Hum. Genet., 51, 92–100.
Spirio, L., Olschwang, S., Groden, J. et al. (1993) Alleles of the APC gene: an attenuated form of familial polyposis. Cell, 75, 951–7.
Lynch, H.T., Lanspa, S., Smyrk, T. et al. (1991) Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): genetics, pathology, natural history, and cancer control, Part 1. Cancer Genet. Cytogenet., 53, 143–60.
Watson, P. and Lynch, H.T. (1993) Extracolonic cancer in hereditary nonpolyposis colorectal cancer. Cancer, 71, 677–85.
Sankiujl, M.A. and Bishop, T. (1994) Results of joint analysis of the EUROFAP Linkage Data, in Genetic and Clinics of HNPCC: Proceedings of the 4th Copenhagen Workshop: EUROFAP (ed. J. Mohr), P. 26.
Ford, D., Easton, D.F., Bishop, D.T., Narod, S.A. and Goldgar, D.E. (1994) Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Lancet, 343, 692–5.
Hamilton, S.R., Liu, B., Parsons, R.E. et al. (1995) The molecular basis of Turcot’s syndrome. N. Engl. J. Med., 332, 839–17.
St John, D.J.B., McDermott, F.T. and Hopper, V.L. (1993) Cancer risk in relatives of patients with common colorectal cancer. Ann. Intern. Med., 118, 785–90.
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Murday, V.A., Bishop, D.T., Hall, N.R. (1996). Familial colon cancer syndromes and their clinical management. In: Eeles, R.A., Ponder, B.A.J., Easton, D.F., Horwich, A. (eds) Genetic Predisposition to Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-4501-3_20
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DOI: https://doi.org/10.1007/978-1-4899-4501-3_20
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