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Familial breast cancer

  • David E. Goldgar
  • Michael R. Stratton
  • Rosalind A. Eeles

Abstract

Breast cancer has been recognized for over 100 years as having a familial component [1]. More recently, a number of epidemiological investigations have attempted to quantify the risks of breast cancer associated with a positive family history. Attempts have also been made to examine whether the pattern of related individuals with breast cancer are consistent with the effects of a single gene of large effect, shared environmental effects, many genes acting in an additive manner, or most likely, a combination of two or more of these effects. In addition to this statistical and observational evidence for the role of genes in the development of breast cancer, a number of specific genes have been identified as playing a role. Perhaps the most notable of these genes is BRCA1, which was identified through genetic linkage studies and localized to the long arm of chromosome 17 [2]. Because BRCA1 has been extensively studied, it is the subject of a separate chapter (Chapter 15) in this book. However, the BRCA1 gene accounts for, at most, half (and probably less) of all familial breast cancer. In this chapter, we will begin by examining the epidemiological evidence for familial risks in breast cancer, then discuss the results of statistical analyses of breast cancer families for the presence of major genetic effects, and describe specific genes other than BRCA1 which influence breast cancer risk. We will also present evidence that additional genes exist, as yet unmapped, which account for a substantial proportion of familial breast cancer.

Keywords

Breast Cancer Ovarian Cancer Breast Cancer Risk Familial Risk Familial Breast Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1996

Authors and Affiliations

  • David E. Goldgar
  • Michael R. Stratton
  • Rosalind A. Eeles

There are no affiliations available

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