Macrophages and Natural Resistance to Virus Infections
More than two decades ago Mims (1964) stated in his classical review of aspects of the pathogenesis of virus diseases: “Macrophages are literally in a position to control the susceptibility of animals to virus infections, since they monitor the main body compartments and may control the entry of viruses to target organs like the liver.” Since then, the position of macrophages as important elements in the host defense armamentarium against a variety of virus infections has been further substantiated and the interplay between macrophages and other defense mechanisms elucidated (Gresser and Lang, 1966; Allison, 1974; Mogensen, 1979; Morahan and Morse, 1979; Virelizier, 1981; Morahan, 1984; Mogensen and Vi-relizier, 1987).
KeywordsInfluenza Virus Virus Replication Herpes Simplex Virus Type West Nile Virus Peritoneal Macrophage
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