Influence of Some Drugs on ISE Measurements of Serum Electrolytes
Since the early days of analytical applications of ion-selective electrodes they have been used in clinical analysis.1–6 The progress in construction and miniaturisation of electrodes as well as contemporary development of computerised Potentiometric apparatus have led to the production of automatic analyzers designed especially for clinical applications.7–11 The high degree of response selectivity of the membrane sensors used today eliminates practically the mutual interaction of various blood, serum, plasma or urine components. Nevertheless when drugs or their metabolites are introduced into the body they in some cases may influence the electrode response and cause errors in estimation of the content of the ions present naturally, i.e., potassium, sodium, calcium and chloride. Such parasitic effects may be caused by the interaction of drugs with the electrode membrane. The aim of this study was to check whether some selected drugs can influence the determination of the above mentioned electrolyte ions in the serum.
KeywordsSelectivity Coefficient Electrode Membrane Electrode Response Membrane Sensor Parasitic Effect
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- 1.J.H. Ladenson, Anal. Proc., 20 (1983) 554.Google Scholar
- 4.R.J. Cooke and R.L. Jensen, Clin. Chem., 29 (1983) 867.Google Scholar
- 5.M.E. Meyerhoff, Y.M. Fraticelli, J.A. Greenberg, J. Rosen, S.J. Parck and W.N. Opdycke, Clin. Chem., 29 (1982) 1973.Google Scholar
- 6.R.J. Cooke and R.L. Jensen, Clin. Chem., 29 (1983) 1563.Google Scholar
- 7.A. Sibbald, A.K. Covington and E.A. Cooper, Clin. Chem., 29 (1983) 405.Google Scholar
- 8.D.D. Koch, D. Parrish and J.H. Ladenson, Clin. Chem., 29 (1983) 1090.Google Scholar
- 9.A. Sibblad, A.K. Covington and E.A. Cooper, Clin. Chem., 30 (1984) 135.Google Scholar
- 10.N. Fogh-Andersen, P.D. Wimberley, J. Thode and O. Siggaard-Andersen, Clin. Chem., 30 (1984) 433.Google Scholar
- 11.J.H. Ladenson, J.J. Apple, J.J. Aguanno and D.D. Koch, Clin. Chem., 28 (1982) 1447.Google Scholar