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Influence of Some Drugs on ISE Measurements of Serum Electrolytes

  • Ryszard Lewandowski
  • Tomasz Sokalski
  • Adam Hulanicki

Abstract

Since the early days of analytical applications of ion-selective electrodes they have been used in clinical analysis.1–6 The progress in construction and miniaturisation of electrodes as well as contemporary development of computerised Potentiometric apparatus have led to the production of automatic analyzers designed especially for clinical applications.7–11 The high degree of response selectivity of the membrane sensors used today eliminates practically the mutual interaction of various blood, serum, plasma or urine components. Nevertheless when drugs or their metabolites are introduced into the body they in some cases may influence the electrode response and cause errors in estimation of the content of the ions present naturally, i.e., potassium, sodium, calcium and chloride. Such parasitic effects may be caused by the interaction of drugs with the electrode membrane. The aim of this study was to check whether some selected drugs can influence the determination of the above mentioned electrolyte ions in the serum.

Keywords

Selectivity Coefficient Electrode Membrane Electrode Response Membrane Sensor Parasitic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Ryszard Lewandowski
    • 1
  • Tomasz Sokalski
    • 1
  • Adam Hulanicki
    • 1
  1. 1.Department of ChemistryUniversity of WarsawWarsawPoland

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