Biochemistry and Molecular Biology of Insect Cytochrome P450

  • R. Feyereisen
  • J. F. Koener
  • F. A. Cariño
  • A. S. Daggett


Cytochrome P450 monooxygenases (P450) are a diverse and ubiquitous group of enzymes encoded by genes from a superfamily comprising at least 17 families, and probably many more (Nebert and Gonzalez, 1987; Nebert et al., 1989). Our present understanding of P450 enzymes comes mainly from studies of P450 in vertebrates, where they are involved in steroid biosynthesis and in the metabolism of drugs and chemical carcinogens, and in bacteria, with P450 cam from Pseudomonas putida being the only P450 enzyme for which a crystal structure is presently available (Poulos et al., 1987).


P450 Protein Insecticide Resistance P450 Reductase Musca Domestica Cytochrome P450 Reductase 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. Feyereisen
    • 1
  • J. F. Koener
    • 1
  • F. A. Cariño
    • 1
  • A. S. Daggett
    • 1
  1. 1.Department of EntomologyOregon State UniversityCorvallisUSA

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