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Role of Platelet Activating Factor in the Adhesion Process of Polymorphonuclear Neutrophils to Endothelial Cells

  • Federico Bussolino
  • Daniela Alessi
  • Ernesto Turello
  • Giovanni Camussi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 297)

Abstract

Circulating polymorphonuclear neutrophils (PMN) provide a front line of defense that can be rapidly mobilized and activated against infectious and toxic agents. The first step in extravasion involves the adhesion of neutrophils to vascular endothelium. This process must be regulated to allow localization of neutrophils only to inflammatory sites. Chemotactic factors, cytokines or lipid mediators released at the inflamed sites may modify the characteristics of plasma-membrane surface of PMN, endothelial cells (EC) or of both and promote PMN-EC adhesion (reviewed in 1). For example, the leukocyte CD11/CD18 surface adhesive complex and its ligand (intercellular adhesion molecule 1) on EC surface, are essential in the PMN extravasion process and their expression can be up-regulated by cytokines and chemotactic peptides (2–4). Interleukin-1 and tumor necrosis factor induce a transient expression of the glycoprotein endothelial-leukocyte adhesion molecule-1 on EC surface that mediate PMN-EC interaction (4,5).

Keywords

Platelet Activate Factor Adhesion Assay Polymorphonuclear Neutrophil Endothelial Cell Surface Chemotactic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Federico Bussolino
    • 1
    • 2
  • Daniela Alessi
    • 1
    • 2
  • Ernesto Turello
    • 1
    • 2
  • Giovanni Camussi
    • 1
    • 2
  1. 1.Dipartimento di Genetica, Biologia e Chimica Medica, Laboratorio di ImmunopatologiaUniversita’ di TorinoItaly
  2. 2.Dipartimento di Biochimica e BiofisicaUniversita’ di NapoliItaly

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