Abstract
Physiological responses of neutrophils and macrophages are crucially dependent on their motility as they undergo random or directed locomotion, pinocytosis, phagocytosis and exocytosis (granule movement). Each of these functions requires complex interactions between surface receptors, the cytoskeleton and the plasma membrane (Silverstein et al., 1977).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams, R. J., Pollard, T.D., 1989. Binding of myosin I to membrane lipids. Nature (London) 340:565.
Brundage, R.A., Fay, F.S., 1989. The role of Ca2+ in the polarization and Chemotaxis of newt eosinophils. J. Cell Biol. 107:17a (abstract).
Bengtsson, T., Rundquist, I., Stendahl, O., Wymann, M., Andersson, T., 1988. Increased breakdown of phosphatidyl-inositol 4,5-bisphosphate is not an initiating factor for actin assembly in human neutrophils. J. Cell Biol. 263:17385.
Campbell, A.K., Hallet, M.B., 1983. Measurement of intracellular calcium ions and oxygen radicals in polymorphonuclear leukocyte-erythrocyte ghost hybrids. J. Physiol. (London) 338:537.
Carson, M., Weber, A, Zigmond, S.H., 1986. An actin-nucleating activity in polymorphonuclear leukocytes is modulated by chemotactic peptides. J. Cell Biol. 103:2707.
Delia Bianca, V., Grzeskowiak, M., Rossi, F., 1990. Studies of molecular regulation of phagocytosis and activation of NADPH oxidase in neutrophils. IgG and C3b-mediated ingestion and associated respiratory burst independent of phosphatidyl turnover and Ca2+ transients. J. Immunol. in press.
De Lozanne, A., Spudich, J.A., 1987. Disruption of the Dicty-ostelium myosin heavy chain gene by homologous recombination. Science 236:1086.
Di Virgilio, F., Lew, D.P., Pozzan, T., 1984. Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytoslic Ca2+ levels. Nature (London) 310:691.
Di Virgilio, F., Meyer, B.C., Greenberg, S., Silverstein, S.C., 1988a. Fc-receptor-mediated phagocytosis occurs in macrophages at exceedingly low cytosolic Ca2+ levels. J. Cell Biol. 106:657.
Di Virgilio, F., Steinberg, T.H., Swanson, J.A., Silverstein, S.C., 1988b. Fura-2 secretion and sequestration in macrophages. A blocker of organic anion transport reveals that these processes occur via a membrane transport system for organic anions. J. Immunol. 140:915.
Di Virgilio, F., Fasolato, C., Steinberg, T.H., 1988c. Inhibitors of membrane transport system for organic anions block fura-2 excretion from PC12 and N2A cells. Biochem. J. 256:959.
Di Virgilio, F. Stendahl, O., Pittet, D., Lew D.P., Pozzan, T., 1990. Cytoplasmic calcium in phagocyte activation. Current Topics in Membranes and Transport 3 5 (in press).
Fukui, Y., Lynch, T.J., Brzeska, H., Korn, E.D., 1989. Myosin I is located at the leading edges of locomoting Dictyostelium amoebae. Nature (London) 341:328.
Griffin, F.M., Jr., Griffin, J.A., Silverstein, S.C., 1976. Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes. J. Exp. Med. 144:788.
Jaconi, M.E.E., Rivest, R.W., Schlegel, W., Wollheim, C.B., Pittet, D., Lew, P.D., 1988. Spontaneous and chemoattractant-induced oscillations of cytosolic free Ca2+ in single adherent human neutrophils. J. Biol. Chem. 263:10557.
Janmey, P.A., Stossel, T.P., 1987. Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature (London) 325:362.
Knecht, D.A., Loomis, W.F., 1987. Antisense RNA inactivation of myosin heavy chain gene expression in Dictyodtelium Discoideum. Science 236:1081.
Kruskal, B.A., Maxfield, F.R., 1987. Cytosolic free calcium increases before and oscillates during frustrated phagocytosis in macrophages. J. Cell Biol. 105:2 685.
Lassing, I., Lindberg, U., 1985. Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature (London) 314:472.
Lew, P.D., Andersson, T., Di Virgilio, F., Pozzan, T., Stendahl, O., 1985. Ca2+-independent phagocytosis in human neutrophils. Nature (London) 315:509.
Lew, P.D., Monod, A., Krause, K.H., Waldvogel, F.A., Biden, T.J., Schlegel, W., 1986. The role of cytosolic calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL60 cells: differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels. J. Biol. Chem. 261:13121.
McNeil, P.L., Murphy, R.F., Lanni, F., Taylor, D.L., 1984. A method for incorporating macromolecules into adherent cells. J. Cell Biol. 98:1556.
McNeil, P.L. Swanson, J.A., Wright, S.D., Silverstein, S.C., Taylor, D.L., 1986. Fc-receptor-mediated phagocytosis occurs in macrophages without an increase in average (Ca2+)i. J. Cell Biol. 102:1586.
Meshulam, T., Proto, P., Diamond, R.D., Melnick, D.A., 1986. Calcium modulation and chemotactic response: divergent stimulation of neutrophil Chemotaxis and cytosolic calcium response by the chemotactic peptide receptor. J. Immunol. 137:1954.
Pozzan, T., Lew, D.P., Wollheim, C.B., Tsien, R.Y., 1983. Is cytosolic ionized calcium regulating neutrophil activation? Science 221:1413.
Rossi, F., Delia Bianca, V., Grzeskowiak, M., Bazzoni, F., 1989. Studies on molecular regulation of phagocytosis in neutrophils. Con A-mediated ingestion and associated respiratory burst independent of phosphoinositide turnover, rise in (Ca2+)i and arachidonic acid release. J. Immunol. 142:1625.
Sawyer, D.W., Sullivan, J.A., Mandell, G.L., 1985. Intracellular free calcium localization in neutrophils during phagoytosis. Science 230:663.
Sha’afi, R.I., Shefcyk, J., Yassin, R., Molski, T.F.P., Volpi, M., Naccache, P.H., White, J.R., Feinstein, M.B., Becker, E.L., 1986. Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin. J. Cell Biol. 102:1459.
Sheterline, P. Rickard, J.E., Richards, R.C., 1984. Fc-receptor-directed phagocytic stimuli induce transient actin assembly at an early stage of phagocytosis in neutrophil leukocytes. Eur. J. Cell Biol. 34:80.
Sheterline, P., Rickard, J.E., Boothroyd, B., Richards, R.C., 1986. Phorbol esters induce rapid actin assembly in neutrophil leukocytes independently of changes in (Ca2+)i and pHi. J. Muscle Res. Cell Motil. 7:405.
Sklar, L.A., Omann, G.M., Painter, R.G., 1985. Relationship of actin polymerization and depolymerization to light scattering in human neutrophils: dependence on receptor occupancy and intracellular Ca2+. J. Cell Biol. 102:1459.
Silverstein, S.C., Steinmann, R.M., Cohn, Z.A., 1977. En-docytosis. Annu. Rev. Biochem. 46:669.
Silverstein, S.C., Greenberg, S., Di Virgilio, F., Steinberg, T.H., 1989. Phagocytosis, in “Fundamental Immunology”, W. Paul ed. Raven Press, New York.
Steinberg, T.H., Newman, A., Swanson, J.A., Silverstein, S.C., 1987. ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes. J. Biol. Chem. 262:8884.
Stossel, T.P., 1988. The mechanical responses of withe blood cells. in “Inflammation: Basic Principles and Clinical Correlates”. Gallin, J.I., Goldstein, I.M. and Snydermann R, eds. Raven Press, Ltd. New York.
Tiffert, T., Garcia-Sancho, J., Lew, V.L., 1984. Irreversible ATP depletion caused by low concentrations of formaldehyde and of calcium-chelator esters in intact human red cells. Biochim. Biophys. Acta. 773:143.
Trotter, J.A., Adelstein, R.S., 1979. Macrophage myosin: regulation of actin-activated ATPase activity by phosphorylation of the 20,000-dalton light chain. J. Biol. Chem. 260:8781.
Volpe, P., Krause, K.H., Hashimoto, S., Zorzato, F., Pozzan T., Meldolesi, J., Lew, D.P., 1988. Calciosome, a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of non-muscle cells. Proc. Natl. Acad. Sci. USA 85:1091.
Wang, E., Michl, J., Pfeffer, L.M., Silverstein, S.C., 1984. Interferon suppresses pinocytosis but stimulates phagocytes in mouse peritoneal macrophages: related changes in cytoskeletal organization. J. Cell Biol. 98:1328.
Wood, D.S., Zollman, J.R., Reuben, J.P, Brandt, P.W., 1975. Human skeletal muscle: properties of the chemically skinned fiber. Science 187:1075.
Wuestenhube, L.J., Luna, E.J., 1987. F-actin binds to the cytoplasmatic surface of ponticulin, a 17-kDa integral glycoprotein from Dictyostelium discoideum plasma membranes. J. Cell Biol. 105:1741.
Young, J.D.-E., Ko, S.S., Cohn, Z.A., 1984. The increase in intracellular free Ca2+ associated with IgG 2b/l Fc receptor-ligand interaction: role in phagocytosis. Proc. Natl. Acad. Sci. USA 81:5430.
Zigmond, S.H., Slonczewski, J.L., Wilde, M.W., Carson, M., 1988. Polymorphonuclear leukocyte locomotion is insensitive to lowered cytoplasmic calcium levels. Cell Motility and the Cytoskeleton 9:184.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Di Virgilio, F., Pizzo, P., Picello, E. (1991). Mechanisms of Neutrophil and Macrophage Motility. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Aspects of Human Polymorphonuclear Leukocytes. Advances in Experimental Medicine and Biology, vol 297. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3629-5_2
Download citation
DOI: https://doi.org/10.1007/978-1-4899-3629-5_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-3631-8
Online ISBN: 978-1-4899-3629-5
eBook Packages: Springer Book Archive