Blood Flow Dependent Granulocyte Activation in Membranes with and Without Complement Activation
Granulocyte activation during hemodialysis with cuprophane membranes has conclusively been shown to be mediated by complement activation inside the hemodialyzer1,2. Synthetic hemodialysis membranes cause little alteration of the complement system as indicated by low levels of C3a3, C5a4, or C5b-95 at the hemodialyzer blood outlet. However, we previously demonstrated that one of these synthetic membranes made from polymethylmethacrylate (PMMA), very strongly activates granulocytes in patients during HD-treatment despite minimal complement activation6. To determine whether this observation is specific for the PMMA polymer or seen in other synthetic membranes as well, we studied 3 synthetic membranes in comparison to cuprophane.
KeywordsComplement Activation Membrane Material Blood Compartment Complement Fragment Synthetic Membrane
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