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Treatment of Aspergillus Keratitis with Imidazoles and Related Compounds

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Aspergillus and Aspergillosis

Abstract

In this study conducted over a period of thirty months, 228 cases of mycotic keratitis were treated with ketoconazole, itraconazole or amphotericin B. This included 69 cases of Aspergillus keratitis. In general, severity of the keratitis influenced response to therapy with all three compounds. A positive correlation was made between age and response of Aspergillus keratitis to itraconazole. Aspergillus keratitis was found to respond more frequently to itraconazole than to ketoconazole or amphotericin B. Itraconazole was significantly superior to ketoconazole and apparently superior to amphotericin B in the treatment of severe Aspergillus keratitis. Although oral azole therapy was not associated with major drawbacks, topical azole therapy was frequently hampered by ocular irritation and inefficacy in treating severe keratitis. Itraconazole may emerge as the drug of choice in treating Aspergillus keratitis.

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Authors and Affiliations

  1. Departments of Microbiology and Ophthalmology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, 620 001, India

    Philip A. Thomas & J. Rajasekaran

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  1. Philip A. Thomas
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  2. J. Rajasekaran
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Editors and Affiliations

  1. Janssen Research Foundation, Beerse, Belgium

    Hugo Vanden Bossche  & Geert Cauwenbergh  & 

  2. Mycological Reference Laboratory, London, UK

    Donald W. R. Mackenzie

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© 1988 Springer Science+Business Media New York

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Thomas, P.A., Rajasekaran, J. (1988). Treatment of Aspergillus Keratitis with Imidazoles and Related Compounds. In: Vanden Bossche, H., Mackenzie, D.W.R., Cauwenbergh, G. (eds) Aspergillus and Aspergillosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3505-2_23

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  • DOI: https://doi.org/10.1007/978-1-4899-3505-2_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-3507-6

  • Online ISBN: 978-1-4899-3505-2

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