Sterol Metabolism in Aspergillus Species
The functional complexity of the eukaryotic membrane requires a similar structural complexity. One of the major components of the membrane is the sterol molecule, such as cholesterol (in animals), sitosterol (in plants), and ergosterol (in fungi). These neutral lipid molecules act not only as a bulk lipid, but also act to stabilize the fluidity of the membrane structure, thus allowing for protein function under conditions such as high or low temperature under which the phospholipid hydrocarbon chains might either gel or become too fluid for proper physiological functioning.
KeywordsHigh Performance Liquid Chromatography Aspergillus Nidulans Sterol Ester Free Sterol Steryl Ester
Unable to display preview. Download preview PDF.
- Anisimov, M. M., Shcheglov, V. V., Stringina, L. I., Chetyrina, N. S., Uvarova, N. I., Oshitok, G. I., Alad’ina, N. G., Vecherko, L. P., Zorina, A. D., Matyukjina, L. G. and Saltykova, I. A., 1979, Chemical structure and antifungal activity of a number of triterpenoids. Izve. stiya Akademii Nauk SSSR. Seriya Biologicheskaya. No. 4: 570.Google Scholar
- Barton, D. H. R., and Bruun, T., 1951. A new sterol from a strain of Aspergillus niger, J. Chem. Soc., 2728.Google Scholar
- Berry, D. R., Chmiel, A., and Al Obaidi, Z., 1977, Citric acid production by A. niger, in: “Genetics and Physiology of Aspergillus,” J. E. Smith and J. A. Pateman, eds., Academic Press: New York.Google Scholar
- Budzikiewicz, H., Djerassi, C., and Williams, D. H., 1964, “Structure elucidation of natural products by mass spectrometry. Vol. II: Steroids, Terpenoids, Sugars, and Miscellaneous Classes,” Holden-Day, San Francisco.Google Scholar
- Gealt, M. A., 1983, Isolation of β-amyrin from the fungus Aspergillus nidulans, J, Gen. Microbiol., 129:543.Google Scholar
- Goulston, G., Mercer, E., and Goad, L., 1975, The identification of 24-methylene-24, 25-dihydrolanosterol and other possible ergosterol precursors in Phycomyces blakesleeanus and Agaricus campestris, Biochem., 14:457.Google Scholar
- Kurtz, M. B., 1980, Regulation of fructose transport during growth of Aspergillus nidulans. J. Gen. Microbiol., 118:389.Google Scholar
- Nes, W. R., and McKean, M. L., 1977, “Biochemistry of Steroids and Other Isopentenoids,” University Park Press, Baltimore.Google Scholar
- Shcheglov, V. V., and Anisimov, M. M., 1979, Change in the biosynthesis of sterols and fatty acids during growth of a culture of Saccharomyces carlsbergensis, Izvestiya Akademii Nauk SSSR, Seriya Biologicheskaya, No. 3: 462.Google Scholar
- Van Etten, J. L., and Gottlieb, D., 1965, Biochemical changes during the growth of fungi. II. Ergosterol and fatty acids of Penicillium atrovenetum, J. Bacteriol., 80:409.Google Scholar
- Weinberg, E., 1977, “Minerals and Microorganisms,” Dekker, New York.Google Scholar