Abstract
The pivotal role of the phagocyte in host defense against invasive aspergillosis can be surmised from a wide variety of observations. Occurrence of this infection in 40 of 245 patients with chronic granulomatous disease is a strong indication that impaired oxidative killing of Aspergillus by human phagocytes put these patients at increased risk (Cohen et al., 1981). Patients with acute leukemia and prolonged granulocytopenia have also been shown to be at increased risk of invasive aspergillosis (Gerson et al., 1984). In contrast, patients with deficient humoral immunity are not known to have increased susceptibility to this or any other mycosis. Patients with the acquired immune deficiency syndrome and its attendant lymphocyte defects have a striking susceptibility to cryptococcosis and mucosal candidiasis, but no noticeable propensity toward developing aspergillosis. None of these differences in the prevalence of aspergillosis are readily ascribed to difference in exposure to Aspergillus. because this fungus is ubiquitous in the environment.
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Bennett, J.E. (1988). Role of the Phagocyte in Host Defense against Aspergillosis. In: Vanden Bossche, H., Mackenzie, D.W.R., Cauwenbergh, G. (eds) Aspergillus and Aspergillosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3505-2_10
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DOI: https://doi.org/10.1007/978-1-4899-3505-2_10
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