Lithium in the prophylaxis of depressive illness in late life
Depression is one of the most common symptoms presented by the elderly (Kantor and Glassman, 1980). Depressive illness is a recurrent condition in 60% of cases and usually presents for the first time in the 40s. Depression in the older age group consists of patients whose illness arose earlier in life and persists until the older ages, and patients in whom depression presents for the first time in late life after 70.
KeywordsPlacebo Toxicity Depression Lithium Folate
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- Angst, J. (1981) Clinical indications for a prophylactic treatment of depression. Adv. Biol. Psychiat., 7, 218–29.Google Scholar
- Coppen, A., Metcalfe, M. and Bailey, J. (1979) Lithium prophylactic therapy in unipolar depression and some possible prognostigators of response. In: Lithium Controversies and Unresolved Issues (eds. T.B. Cooper, S. Gershon, N.S. Kline and M. Scholl), Excerpta Medica, Amsterdam, pp. 401–12.Google Scholar
- Eysenck, H.J. and Eysenck, S.B.G. (1964) Manual of Eysenck Personality Inventory, University of London Press, London.Google Scholar
- Glen, A. (1981) Lithium and antidepressants in the prophylaxis of depression. Adv. Biol Pyschiat., 7, 208–17.Google Scholar
- Greenblatt, D.J., Divoli, M., Abernethy, D.R. and Shader, R.I. (1982) Physiologic change in old age: relation to altered drug disposition. J. Am. Geriat. Soc., 30, (Suppl.) S6–S10.Google Scholar
- Jerram, T.C. and McDonald, R. (1978) Plasma lithium control with particular reference to minimum effective levels. In: Lithium in Medical Practice (eds. F.N. Johnson and S. Johnson), MTP Press, Lancaster, pp. 407–13.Google Scholar
- Quitkin, F., Rifkin, A. and Kane, J. (1978) Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report. Am. J. Psychiat., 133, 570–2.Google Scholar