Abstract
While the prognosis of depression in old age is not directly equivalent to the outcome of controlled trials of treatment, it is closer to clinical reality and has been researched in more detail. It is likely to be affected by current clinical practice. Factors like concurrent physical illness, preoccupation with bodily symptoms and neurotic presentation can lead to underdiagnozing depression in the elderly (Baldwin, 1988), and there is some evidence that General Practitioners (MacDonald, 1986) and even psychogeriatric services (Baldwin, 1988) do not treat depression effectively. At the same time elderly depressed patients require one and a half times as many bed days as their younger counterparts and use a quarter of all acute bed days in a general psychiatric hospital (Murphy and Grundy, 1984). Meanwhile a controversy about whether to stress the hopeful or the gloomy aspects of outcome studies (Murphy, 1987; Baldwin and Jolley, 1987) may reflect a degree of helplessness in the face of a puzzling array of outcome data.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Anonymous (1986) Predicting chronicity in depression (leading article). The Lancet, ii, 897–8.
Baldwin, R.C. (1988) Late life depression: undertreated? Brit. Med. J., 296, 519.
Baldwin, R.C. and Jolley, D.J. (1986) The prognosis of depression in old age. Brit. J. Psychiat., 149, 574–83.
Baldwin, R.C. and Jolley, D.J. (1987) Prognosis of depression in old age (letter). Brit. J. Psychiat., 151, 129.
Bielski, R.J. and Friedel, O. (1976) Prediction of tricyclic antidepressant response. A critical review. Arch. Gen. Psychiat., 33, 1479–89.
Blazer, D.G. (1982) Depression in Late Life, C.V. Mosby, St. Louis.
Burvill, P.W., Stampfer, H. and Hall, W. (1986) Does depressive illness in the elderly have a poor prognosis? Austr. N.Z. J. Psychiatry, 20, 422–7.
Cole, M. and Hickie, R.N. (1976) Frequency and significance of minor organic signs in elderly depressives. Can. Psychiat. Ass. J., 21, 7–12.
Cole, M.G. (1983) Age, age of onset and course of primary depressive illness in the elderly. Can. J. Psychiatry, 28, 102–4.
Coryell, W., Coppen, A., Zeigler, V.E. and Briggs, J.T. (1982) Early improvement as a predictor of response to amitriptyline and nortriptyline: a comparison of two patient samples. Psychol. Med., 12(1), 135–9.
Downing, R.W. and Rickeis, K. (1983) Physician prognosis in relationship to drug and placebo response in anxious and depressed psychiatric outpatients. J. Nerv. Mental Dis., 171 (37), 182–5.
Fähndrich, E. (1983) Clinical and biological parameters as predictors for antidepressant drug responses in depressed patients. Pharmacopsychiat., 16, 179–85.
Fähndrich, E. (1984) Wann gebe ich im Einzelfall welches Antidepressivum? Nervenarzt, 55, 477–82.
Georgotas, A., McCue, R.E., Friedman, E. and Cooper, T.B. (1987) Response of depressive symptoms to nortriptyline, phenelzine and placebo. Brit. J. Psychiat., 151, 102–6.
Georgotas, A., Stokes, P., McCue, R.E. et al. (1986) The usefulness of DST in predicting response to antidepressants: a placebo-controlled study. J. Affect. Disord., 11, 21–8.
Godber, C., Rosenwinge, H., Wilkinson, D. and Smithies, J. (1987) Depression in old age: prognosis after ECT. Internat. J. Geriat. Psychiatry, 2, 19–24.
Hsiao, J.K., Agren, H., Bartko, J.J. et al. (1987) Monoamine neurotransmitter interactions and the prediction of antidepressant response. Arch. Gen. Psychiat., 44, 1078–83.
Jacoby, R.J., Levy, R. and Bird, J.M. (1981) Computerized tomography and the outcome of affective disorder: a follow-up study of elderly patients. Brit. J. Psychiat., 139, 288–92.
Jacoby, R.J., Levy, R. and Dawson, J.M. (1980) Computerized tomography in the elderly: 3. Affective disorder. Brit. J. Psychiat., 136, 270–5.
Jarvik, L.F. and Gerson, S. (1985) Outcome of drug treatment in depressed patients over the age of fifty. In: Treatment of Affective Disorders in the Elderly (ed. C.A. Shanovian), American Psychiatric Press, Washington, D.C.
Jarvik, L.F., Read, S.L., Mintz, Z. and Neshkes, R.E. (1983) Pretreatment orthostatic hypotension in geriatric depression: predictor of response to imipramine and doxepin. J. Clin. Psychopharmacol., 3(6), 368–72.
Joffe, R., Brown, P., Bienenstock, A. and Mitton, J. (1984) Neuroendocrine predictors of the antidepressant effect of partial sleep deprivation. Biol. Psychiat., 19(3), 347–52.
Katz, M.M., Koslow, S.H., Maas, J.W. et al. (1987) The timing, specificity and clinical prediction of tricyclic drug effects in depression. Psychol. Med., 17, 297–309.
Kay, D.W.K. (1962) Outcome and cause of death in mental disorders of old age: a long-term follow-up of functional and organic psychoses. Act. Psychiat. Scand., 38, 249–76.
Kral, V.A. (1983) The relationship between senile dementia (Alzheimer type) and depression. Can. J. Psychiatry, 28, 304–6.
Loosen, P.T. and Prange, A.Z. (1982) Serum thyrotropin response to thyrotropin releasing hormone in psychiatric patients: a review. Am. J. Psychiat., 139, 405–16.
MacDonald, A.J.D. (1986) Do General Practitioners ‘miss’ depression in elderly patients? Brit. Med. J., 292, 1365–7.
Maj, M., Arena, F., Lovero, N. et al. (1985) Factors associated with response to lithium prophylaxis in DSM-III major depression and bipolar disorder. Pharmacopsychiat., 18, 309–13.
Maj, M., Del Vechio, M., Starace, , et al. (1984) Prediction of affective psychoses response to lithium prophylaxis. The role of socio-demographic, clinical, psychological and biological variables. Acta. Psychiat. Scand., 69, 37–44.
Mann, A.H., Jenkins, R. and Belsey, E. (1981) The twelve month outcome of patients with neurotic illness in General Practice. Psychol. Med., 11, 535–50.
Mendlewicz, J. (1976) The age factor in depressive illness: some genetic considerations. J. of Gerontol, 31, 300–3.
Möller, H.J., Fischer, G. and v. Zerssen, D. (1987) Prediction of therapeutic response in acute treatment with antidepressants. Eur. Arch. Psychiatr. Neurol. Sci., 236, 349–57.
Møller, S.E. and Larsen, O.B. (1984) Tryptophan and tyrosine availability: relation to clinical response to antidepressive pharmacotherapy. In: Frontiers in Biochemical and Pharmacological Research in Depression (ed. E. Usdin), Raven Press, New York.
Murphy, E. (1983) The prognosis of depression in old age, Brit. J. Psychiat., 142, 111–19.
Murphy, E. (1987) The prognosis of depression in old age (letter). British J. Psychiat., 150, 268.
Murphy, E. and Grundy, E. (1984) A comparative study of bed usage by younger and older patients with depression. Psychol. Med., 14(2), 445–50.
Neugarten, B.Z. (1970) Adaptation and life cycle. J. Geriatric Psychol., 4, 71.
Post, F. (1962) The Significance of Affective Symptoms in Old Age, Maudsley Monograph 10, Oxford University Press, London.
Post, F. (1972) The management and nature of depressive illness in late life: a follow-through study. Brit. J. Psychiat., 121, 393–404.
Post, F. (1978) The functional psychoses. In: Studies in Geriatric Psychiatry (eds A.D. Isaacs and F. Post), John Wiley, Chichester.
Post, F. (1986) Course and outcome of depression in the elderly. In: Affective Disorders in the Elderly (ed. E. Murphy), Churchill Livingstone, Edinburgh.
Post, F. and Shulman, K. (1985) New views on old age affective disorders. In: Recent Advances in Psychogeriatrics (ed. T. Arie), Churchill Livingstone, Edinburgh.
Priebe, S. (1987) Early subjective reactions predicting the outcome of hospital treatment in depressive patients. Acta. Psychiat. Scand., 76(2), 134–8.
Reynolds, C.F., Perel, J.M., Kupfer, D.J. et al. (1987) Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment. Psychiatry Res., 21, 111–22.
Roth, M. (1983) Depression and affective disorder in late life. In: The Origins of Depression: Current Concepts and Approaches (ed. J. Angst), Springer, Heidelberg.
Surtees, P.G. (1980) Social support, residual adversity and depressive outcome. Social Psychiatry, 15, 71–80.
Watts, C.A.H. (1956) The incidence and prognosis of endogenous depression. Brit. Med. J., 1, 1392–7.
Whitehead, A. and Hunt, D. (1982) Elderly psychiatric patients: a five year prospective study. Psychol. Med., 12, 149–57.
Winokur, G., Behar, D. and Schlesser, M. (1980) Clinical and biological aspects of depression in the elderly. In: Psychopathology in the Aged (eds J.D. Cole and J.E. Barrett), Raven Press, New York.
Young, R.C., Alexopoulos, G.S., Manley, M.L. et al. (1984) Treatment outcome in elderly depressives: plasma nortriptyline concentration and pretreatment dexamethasone suppression test. In: Frontiers in Biochemical and Pharmacological Research in Depression (ed. E. Usdin), Raven Press, New York.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Ebmeier, K.P., Ashcroft, G.W. (1989). Factors influencing the outcome of treatment. In: Ghose, K. (eds) Antidepressants for Elderly People. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3436-9_17
Download citation
DOI: https://doi.org/10.1007/978-1-4899-3436-9_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-412-32460-4
Online ISBN: 978-1-4899-3436-9
eBook Packages: Springer Book Archive