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Adhesion Molecules

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ARDS Acute Respiratory Distress in Adults

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Abstract

The extensive pulmonary vascularization and large number of marginated leukocytes of lung tissue allow for a rapid and wide spread cellular infiltrate in response to infection or other insult. Neutrophils are key effector cells in inflammatory responses, and once recruited they are capable of efficiently killing and degrading certain microorganisms (e.g. streptococci) using a battery of toxic metabolites and degradative enzymes [1,2]. However, excessive release of these histotoxic agents in healthy tissues may also inflict much unwanted tissue injury at sites of inflammation [3]. Thus, an inflammatory response that is too vigorous, or misdirected, may result in damage to host tissue.

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Authors
  1. S. Craig Stocks
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  2. Ian Dransfield
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Editors and Affiliations

  1. National Heart & Lung Institute, USA

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  2. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  3. University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK

    Christopher Haslett FRCP, FRCP (Edin) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories)

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Stocks, S.C., Dransfield, I. (1996). Adhesion Molecules. In: Evans, T.W., Haslett, C. (eds) ARDS Acute Respiratory Distress in Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3430-7_9

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