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Mechanisms of Scarring

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ARDS Acute Respiratory Distress in Adults

Abstract

Pulmonary injury in the syndrome of acute respiratory distress in adults (ARDS) results in disruption of the alveolar-capillary membrane by mechanisms acting directly via the airway or indirectly via the bloodstream [1]. Indeed, within hours of injury there is epithelial and endothelial cell damage and denudation, with exposure and disruption of the epithelial and endothelial basement membranes. Microthrombi form in damaged pulmonary capillaries [2], and breakdown of the alveolar-capillary membrane occurs allowing protein-rich interstitial fluid to flood the alveolus and severely impair gas exchange [3]. Hyaline membranes form [1], and inflammatory cells, initially predominantly activated neutrophils, accumulate in the lung, particularly in the alveolar space (Chapter 4).

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Authors
  1. Patricia J. Sime
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  2. Jack Gauldie
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Editor information

Editors and Affiliations

  1. National Heart & Lung Institute, USA

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  2. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  3. University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK

    Christopher Haslett FRCP, FRCP (Edin) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories)

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© 1996 Springer Science+Business Media Dordrecht

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Sime, P.J., Gauldie, J. (1996). Mechanisms of Scarring. In: Evans, T.W., Haslett, C. (eds) ARDS Acute Respiratory Distress in Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3430-7_13

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  • DOI: https://doi.org/10.1007/978-1-4899-3430-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-412-56910-4

  • Online ISBN: 978-1-4899-3430-7

  • eBook Packages: Springer Book Archive

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