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Lymphadenopathy simulating malignant lymphoma

  • Dennis H. Wright
  • Peter G. Isaacson
Part of the Biopsy Pathology Series book series (BPS)

Abstract

We include in this chapter a miscellaneous group of conditions which cause lymphadenopathy and which may simulate malignant lymphoma clinically and sometimes pathologically. Similar conditions that have a recognized infective cause have been included in Chapter 2. Following previous custom (Butler, 1969; Dorfman and Warnke, 1974; Robb-Smith, 1947) we have divided these conditions into three groups according to the basic histologic pattern observed in the affected lymph node (Table 3.1).

Keywords

Sinus Histiocytosis Malignant Histiocytosis Massive Lymphadenopathy Biopsy Pathology Interdigitating Reticulum Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Azoury, F. J. and Reed, R. J. (1966), Histiocytosis: report of an unusual case. New Engl. J. Med., 274, 928–30.PubMedCrossRefGoogle Scholar
  2. Bartoli, E., Massarelli, G., Soggia, G. and Tanda, F. (1980), Multicentric giant lymph node hyperplasia. A hyperimmune syndrome with a rapidly progressive course. Am. J. Clin. Pathol., 73, 423–6.PubMedGoogle Scholar
  3. Becroft, D. M. O., Dix, M. R., Gillman, J. C. et al. (1973), Benign sinus histiocytosis with massive lymphadenopathy: transient immunological defects in a child with mediastinal involvement. J. Clin. Path., 26, 463–9.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Butler, J. J. (1969), Non-neoplastic lesions of lymph nodes of man to be differentiated from lymphomas. Natl Cancer Inst. Monogr., 32, 233–55.PubMedGoogle Scholar
  5. Castleman, B., Iverson, L. and Menendez, V. P. (1956), Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer, 9, 822–30.PubMedCrossRefGoogle Scholar
  6. Colby, T. V., Burke, J. S. and Hoppe, R. T. (1981), Lymph node biopsy in mycosis fungoides. Cancer, 47, 351–9.PubMedCrossRefGoogle Scholar
  7. Davies, J. D. and Stansfeld, A. G. (1972), Spontaneous infarction of superficial lymph nodes. J. Clin. Pathol., 25, 689–96.PubMedCrossRefPubMedCentralGoogle Scholar
  8. Diamond, L. W. and Braylan, R. C. (1980), Immunological markers and DNA content in a case of giant lymph node hyperplasia (Castleman’s disease). Cancer, 46, 730–5.PubMedCrossRefGoogle Scholar
  9. Digby, J. and Wells, A. L. (1981), Malignant lymphoma with intranodal refractile particles after insertion of silicone prosthesis. Lancet, ii, 580.CrossRefGoogle Scholar
  10. Dorfman, R. F. and Warnke, R. (1974), Lymphadenopathy simulating the malignant lymphomas. Human Pathol., 5, 519–50.CrossRefGoogle Scholar
  11. Foucar, E., Rosai, J. and Dorfman, R. F. (1978), Sinus histiocytosis with massive lymphadenopathy. Ear, nose and throat manifestations. Arch. Otolaryngol., 104, 687–93.PubMedCrossRefGoogle Scholar
  12. Foucar, E., Rosai, J. and Dorfman, R. F. (1979), The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy. Am. J. Ophthamol., 87, 354–67.Google Scholar
  13. Frizzera, G., Moran, E. M. and Rappaport, H. (1975), Angioimmunoblastic lymphadenopathy: diagnosis and clinical course. Am. J. Med., 59, 803–18.PubMedCrossRefGoogle Scholar
  14. Gaba, A. R., Stein, R. S., Sweet, D. L. and Variakojis, D. (1978), Multicentric giant lymph node hyperplasia. Am. J. Clin. Pathol., 69, 86–90.PubMedGoogle Scholar
  15. Haferkamp, O., Roseneau, W. and Lennert, K. (1971), Vascular transformation of lymph node sinuses due to venous obstruction. Arch. Pathol., 92, 81–3.PubMedGoogle Scholar
  16. Hyman, G. A. and Sommers, C. (1966), The development of Hodgkin’s disease and lymphoma during anticonvulsant therapy. Blood, 28, 416–27.PubMedGoogle Scholar
  17. Hymes, K. B., Cheung, T., Greene, J. B. et al. (1981), Kaposi’s sarcoma in homosexual men — A report of eight cases. Lancet, ii, 598–600.CrossRefGoogle Scholar
  18. Jones, D. B., Castleden, M., Smith, J. L. et al. (1978), Immunopathology of angioimmunoblastic lymphadenopathy. Br. J. Cancer, 37, 1053–62.PubMedCrossRefPubMedCentralGoogle Scholar
  19. Keller, A. R., Hochholzer, L. and Castleman, B. (1972), Hyaline-vascular and plasma cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer, 29, 670–83.PubMedCrossRefGoogle Scholar
  20. Kircher, T. (1980), Silicone lymphadenopathy. A complication of silicone elastomer finger joint prostheses. Human Pathol., 11, 240–4.CrossRefGoogle Scholar
  21. Lampert, F. and Lennert, K. (1976), Sinus histiocytosis with massive lymphadenopathy. Fifteen new cases. Cancer, 37, 783–9.PubMedCrossRefGoogle Scholar
  22. Lapes, M. J., Vivacqua, R. J. and Antoniades, K. (1976), Immunoblastic lymphadenopathy associated with phenytoin. (Diphenylhydantoin.) Lancet, i, 198.CrossRefGoogle Scholar
  23. Lattes, R. and Pachter, M. R. (1962), Benign lymphoid masses of probable hamartomatous nature. Cancer, 15, 197–214.PubMedCrossRefGoogle Scholar
  24. Lukes, R. J. and Tindle, B. H. (1975), Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin’s disease. New Engl. J. Med., 292, 1–8.PubMedCrossRefGoogle Scholar
  25. Nathwani, B. N., Rappaport, H., Moran, E. M. et all (1978), Malignant lymphoma arising in angioimmunoblastic lymphadenopathy. Cancer, 41, 578–606.PubMedCrossRefGoogle Scholar
  26. Robb-Smith, A. H. T. (1947), The lymph node biopsy. In Recent Advances in Clinical Pathology (ed. S. C. Dyke), Churchill Livingstone, London, pp. 350–77.Google Scholar
  27. Rosai, J. and Dorfman, R. F. (1972), Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer, 30, 1174–88.PubMedCrossRefGoogle Scholar
  28. Saltzstein, S. L. and Ackerman, L. V. (1959), Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically and pathologically malignant lymphoma. Cancer, 12, 164–82.PubMedCrossRefGoogle Scholar
  29. Scheffer, E., Meijer, C. J. L. M. and Vanvloten, W. A. (1980), Dermatopathic lymphadenopathy and lymph node involvement in mycosis fungoides. Cancer, 45, 137–48.PubMedCrossRefGoogle Scholar
  30. Schroer, K. R. and Franssila, K. O. (1979), Atypical hyperplasia of lymph nodes: A follow-up study. Cancer, 44, 1155–63.PubMedCrossRefGoogle Scholar
  31. Sidky, Y. A. and Aurbach, R. (1975), Lymphocyte induced angiogenesis; a quantitative and sensitive assay of the graft vs. host reaction. J. Exp. Med., 141, 1084–100.PubMedCrossRefGoogle Scholar
  32. Thawerani, H., Sanchez, R. L., Rosai, J. and Dorfman, R. F. (1978), The cutaneous manifestations of sinus histiocytosis with massive lymphadenopathy. Arch. Dermatol., 114, 191–7.PubMedCrossRefGoogle Scholar
  33. Walker, P., Rosai, J. and Dorfman, R. F. (1981), The osseous manifestations of sinus histiocytosis with massive lymphadenopathy. Am. J. Clin. Pathol., 75, 131–9.PubMedGoogle Scholar
  34. Watanabe, S., Shinosato, Y., Shimoyama, M. et al. (1980), Adult T-cell lymphoma with hypergammaglobulinemia. Cancer, 46, 2472–83.PubMedCrossRefGoogle Scholar
  35. Williams, J. and Dorfman, R. F. (1979), Lymphadenopathy as the initial manifestation of histiocytosis X. Am. J. Surg. Pathol., 3, 405–21.PubMedCrossRefGoogle Scholar
  36. Wright, D. H. and Richards, D. B. (1981), Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Report of a case with widespread nodal and extranodal dissemination. Histopathology, 5, 697–709.PubMedCrossRefGoogle Scholar

Copyright information

© D. H. Wright and P. G. Isaacson 1983

Authors and Affiliations

  • Dennis H. Wright
    • 1
    • 2
  • Peter G. Isaacson
    • 1
    • 2
    • 3
  1. 1.The University of SouthamptonUK
  2. 2.Southampton and South-West Hampshire District Health AuthorityUK
  3. 3.School of MedicineUniversity CollegeLondonUK

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