Abstract
This chapter describes the use of beta- or electron-emitting radiopharmaceuticals for treating several painful musculoskeletal conditions. These radiopharmaceuticals emit negatively charged particles (beta particles or electrons) with a maximum range of approximately 1–11 mm (Tables 1.1 and 1.2), which can cause sub-lethal or lethal damage to cells by interacting with their DNA [1]. Radionuclide therapy, by eliminating the targeted cells responsible for tissue damage and the resultant pain, provides marked clinical benefit to the patient.
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References
Phillips, T.L. (1991) Early and late effects of radiation on normal tissues, in Radiation Injury to the Nervous System (eds P.H. Gutin, S.D. Leibel and G.E. Sheline), Raven Press, Ltd., New York, pp. 37–55.
Hosain, F., Haddon, M.J., Hosain, H. et al (1990) Radiopharmaceuticals for diagnosis and treatment of arthritis. Nucl. Med. Biol., 17(1), 151–5.
Gschwend, N. (1989) Synovectomy, in Textbook of Rheumatology, 3rd edn (eds W.N. Kelley, E.D. Harris, S. Ruddy and C.B. Sledge), W.B. Saunders, Philadelphia, pp. 1934–61.
Henderson, B. and Edwards, J.C.W. (1987) The Synovial Lining: In Health and Disease, Chapman & Hall, London.
Noble, J., Jones, A.G., Davis, M.A. et al. (1983) Leakage of radioactive particle systems from a synovial joint studied with a gamma camera: its application to radiation synovectomy.J. Bone Joint Surg. (Am), 65(3), 381–9.
Clunie, G. and Ell, P.J. (1995) A survey of radiation synovectomy in Europe, 1991–1993. Eur. J. Nucl. Med., 22(9), 970–6.
Deutsch, E., Brodack, J.W. and Deutsch, K.F. (1993) Radiation synovectomy revisited. Eur. J. Nucl. Med., 20(11), 1113–27.
Dolphin, G.W. (1973) Biological hazards of radiation. Ann. Rheum. Dis., 32(1), 23–8.
Stevenson, A.C., Bedford, J., Dolphin, G.W. et al. (1973) Cytogenetic and scanning study of patients receiving intra-articular injection of gold-198 and yttrium-90. Ann. Rheum. Dis., 32(1), 112–23.
Rivard, G.E., Girard, M., Lamarre, C. et al. (1985) Synoviorthesis with colloidal 32P chromic phosphate for hemophilic arthropathy: clinical follow-up. Arch. Phys. Med. Rehab., 66, 753–6.
Zuckerman, J.D., Sledge, C.B., Shortkroff, S. et al. (1987) Treatment of rheumatoid arthritis using radiopharmaceuticals. Nucl. Med. Biol., 14(3), 211–18.
McLaren, A., Hetherington, E., Maddalene, D. et al. (1990) Dysprosium (166Dy) hydroxide macroaggre-gates for radiation synovectomy — animal studies. Eur. J. Nucl. Med., 16(6), 627–32.
Gumpel, J.M., Beer, T.C., Crawley, J.C.W. et al. (1975) Yttrium-90 in persistent synovitis of the knee — a single centre comparison. The retention and extra articular spread of four 90Y radiocolloids. Br. J. Radiol., 48(5), 377–81.
Chinai, M., Vallabhajosula, S., Goldsmith, S.J. et al. (1993) Chemistry and biological behavior of samarium-153 and rhenium-186-labeled hydroxyapatite particles: potential radiopharmaceuticals for radiation synovectomy.J. Nucl. Med., 34(9), 1536–42.
Clunie, G., Lui, D., Cullum, I. et al. (1995) Samarium-153 particulate hydroxyapatite radiation synovectomy: biodistribution data for chronic knee synovitis.J. Nucl. Med., 36(1), 51–7.
De la Chapelle, A., Oka, M., Rekonen, A. et al. (1972) Chromosome damage after intra-articular injection of radioactive yttrium. Ann. Rheum. Dis., 31(5), 500–12.
Johnson, L. and Yanch, V. (1991) Absorbed dose profile for radionuclides of frequent use in radiation synovectomy. Arthritis Rheum., 34, 1521–30.
Jones, G. (1993) Yttrium synovectomy: a meta-analysis of the literature. Aust. N. Z. J. Med., 23, 272–5.
Siegel, H.J., Luck, J.V., Siegel, M. et al. (1994) Hemarthrosis and synovitis associated with hemophilia: clinical use of P-32 chromic phosphate synoviorthesis for treatment. Radiology, 190(1), 257–61.
Bates, T., Yarnold, J.R., Blitzer, P. et al. (1992) Bone metastasis consensus statement. Int. J. Radiât. Oncol. Biol. Phys., 23, 215–20.
Salazar, O.M., Rubin, P., Hendrickson, P.R. et al. (1986) Single dose half-body irradiation for palliation of multiple bone metastases from solid tumors. Final Radiation Therapy Oncology Group Report. Cancer, 58, 29–36.
Blake, G.M., Zivanovic, M.A., McEwan, A.J. et al. (1986) Sr-89 therapy: strontium kinetics in disseminated carcinoma of the prostate. Eur. J. Nucl. Med., 12(5), 447–54.
Maxon, H.R., Schroder, L.E., Thomas, S.R. et al. (1992) Re-186 (Sn) HEDP for treatment of painful osseous metastases: initial clinical experience in 20 patients with hormone-resistant prostate cancer, Radiology 176(1), 155–9.
Leong, C., McKenzie, M.R., Coupland, D.B. et al. (1994) Disseminated intravascular coagulation in 9 patients with metastatic prostate cancer: fatal outcome following strontium-89 therapy.J. Nucl. Med., 35(10), 1662–4.
Silberstein, E. and Taylor, A., Jr (1995) Procedure guideline for bone pain treatment: 1.0.J. Nucl. Med., 37(5), 881–4.
Silberstein, E.B. (1993) The treatment of painful osseous metastases with phosphorus-32-labeled phosphates. Semin. Oncol., 20 (suppl. 2), 10–21.
Porter, A.T., McEwan, A.J.M., Powe, J.E. et al. (1993) Results of a randomized phase III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. Int. J. Radial Oncol. Biol. Phys, 25, 805–13.
Quilty, D.M., Kirk, D., Bolger, J.J. et al. (1994) A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. Radiother. Oncol., 31, 33–40.
McEwan, A.J.B., Porter, A.T., Venner, P.M. et al. (1990) An evaluation of the safety and efficacy of treatment with strontium-89 in patients who have previously received wide field radiotherapy. Antibody, Immunoconjugates and Radiopharmaceuticals, 3, 91–8.
Collins, C., Eary, J.F., Donaldson, G. et al. (1993) Samarium-153-EDTMP in bone metastases of hormone refractory prostate carcinoma: a Phase I/II Trial.J. Nucl. Med., 34(12), 1839–44.
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Silberstein, E.B. (1998). Bones and joints. In: Maisey, M.N., Britton, K.E., Collier, B.D. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3356-0_1
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DOI: https://doi.org/10.1007/978-1-4899-3356-0_1
Publisher Name: Springer, Boston, MA
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