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Multiple sclerosis CNS infection

  • G. D. Perkin
Part of the Diagnostic Tests Series book series (DTS)

Abstract

For many patients, the diagnosis of multiple sclerosis is evident from their clinical characteristics. A remitting and relapsing illness in a young adult with signs reflecting scattered white matter dysfunction, hardly requires investigation, though the picture so defined is not unique to multiple sclerosis. Greater uncertainty occurs in the early course of the illness before a remitting and relapsing pattern has been established, or where the disability is progressive from the outset. Previous classifications of the disease allowed for such uncertainties by designating definite, probable or possible categories [1] or definite, early probable/latent and progressive probable/possible cases [2]. The latter criteria include data based on electrophysiological studies. More recently, a classification incorporating CSF data has been introduced [3]. There are no tests which infallibly identify patients with multiple sclerosis. Certainly CSF changes, for example oligoclonal IgG, and abnormalities of central conduction time are seen in other neurological disorders. Even the demonstration of paraventricular pathology by magnetic resonance imagery does not allow a certain diagnosis, since identical appearances are encountered in some patients with cerebrovascular disease [4].

Keywords

Multiple Sclerosis Optic Neuritis Visual Evoke Potential Nuclear Magnetic Resonance Imaging Subdural Empyema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McAlpine, D., Lumsden, C.E. and Acheson, E.D. (1972) Multiple Sclerosis. A Reappraisal. 2nd edn, Churchill Livingstone, Edinburgh, London.Google Scholar
  2. 2.
    McDonald, W.I. and Halliday, A.M. (1977) Diagnosis and classification of multiple sclerosis. Br. Med. Bull., 33, 4–8.PubMedGoogle Scholar
  3. 3.
    Poser, C.M., Paty, D.M., Scheinberg, L. et al. (1983) New diagnostic criteria for multiple sclerosis: guidelines for research proposals. Ann. Neurol., 13, 227–31.PubMedGoogle Scholar
  4. 4.
    Ormerod, I.E.C., Roberts, R.C., du Boulay, E.P.G.H. et al. (1984) NMR in multiple sclerosis and cerebral vascular disease. Lancet, 11, 1334–5.Google Scholar
  5. 5.
    Traugott, U. and Raine, C.S. (1981) Antioligodendrocyte antibodies in cerebrospinal fluid of multiple sclerosis and other neurologic diseases. Neurology, 31, 695–700.PubMedGoogle Scholar
  6. 6.
    Ryberg, B. (1982) Antibrain antibodies in multiple sclerosis. Relation to clinical variables. J. Neurol. Sci., 54, 239–61.PubMedGoogle Scholar
  7. 7.
    Panitch, H.S., Hooper, C.J. and Johnson, K.P. (1980) CSF antibody to myelin basic protein. Measurement in patients with multiple sclerosis and subacute sclerosing panencephalitis. Arch. Neurol., 37, 206–9.PubMedGoogle Scholar
  8. 8.
    Biber, A., Englert, D., Dommasch, D. and Hempel, K. (1981) Myelin basic protein in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. J. Neurol., 225, 231–6.PubMedGoogle Scholar
  9. 9.
    Garcia-Merino, A., Persson, M.A.A., Ernerudh, J. et al. (1986) Serum and cerebrospinal fluid antibodies against myelin basic protein and their IgG subclass distribution in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 49, 1066–70.PubMedGoogle Scholar
  10. 10.
    Warren, K.G. and Catz, I. (1986) Diagnostic value of cerebrospinal fluid anti-myelin basic protein in patients with multiple sclerosis. Ann. Neurol. 20, 20–5.PubMedGoogle Scholar
  11. 11.
    Tachousky, T.G., Lisak, R.P., Koprowski, H. et al. (1976) Circulating immune complexes in multiple sclerosis and other neurological diseases. Lancet, 11, 997–9.Google Scholar
  12. 12.
    Compston, D.A.S., Morgan, B.P., Oleesky, D. et al. (1986) Cerebrospinal fluid C9 in demyelinating disease. Neurology, 36, 1503–5.PubMedGoogle Scholar
  13. 13.
    Dore-Duffy, P., Donaldson, J.O., Rothman, B.L. and Zurier, R.B. (1982) Antinuclear antibodies in multiple sclerosis. Arch. Neurol., 39, 504–6.PubMedGoogle Scholar
  14. 14.
    Selmaj, K., Alam, R., Perkin, G.D. and Clifford Rose, F. (1987) T lymphocyte-derived demyelinating activity in multiple sclerosis patients in acute relapse. J. Neurol. Neurosurg. Psychiatry, 50, 532–7.PubMedGoogle Scholar
  15. 15.
    Cremer, N.E., Johnson, K.P., Fein, G. and Likosky, W.H. (1980) Analysis of serum and CSF antibodies by standard serologic methods. Arch. Neurol, 37, 610–15.PubMedGoogle Scholar
  16. 16.
    Mehta, P.D., Thormar, H. and Wisniewski, H.M. (1980) Quantitation of measles-specific IgG. Its presence in CSF and brain extracts of patients with multiple sclerosis. Arch. Neurol., 37, 607–9.PubMedGoogle Scholar
  17. 17.
    Appel, M.J., Glickman, L.T., Raine, C.S. and Tourtellotte, W.W. (1981) Canine viruses and multiple sclerosis. Neurology, 31, 944–9.PubMedGoogle Scholar
  18. 18.
    Batchelor, J.R., Compston, A. and McDonald, W.I. (1978) The significance of the association between HLA and multiple sclerosis. Br. Med. Bull., 34, 279–84.PubMedGoogle Scholar
  19. 19.
    Müller, R. (1951) The correlation between the state of the cerebrospinal fluid and the clinical picture in disseminated sclerosis. Acta Med. Scand., 139, 153–63.PubMedGoogle Scholar
  20. 20.
    Hart, R.G. and Sherman, D.G. (1982) The diagnosis of multiple sclerosis. J. Am. Med. Assoc., 247, 498–503.Google Scholar
  21. 21.
    Johnson, K.P. (1980) Cerebrospinal fluid and blood assays of diagnostic usefulness in multiple sclerosis. Neurology, 30, 106–9.PubMedGoogle Scholar
  22. 22.
    Link, H. and Müller, R. (1971) Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch. Neurol., 25, 326–44.PubMedGoogle Scholar
  23. 23.
    Caroscio, J.T., Kochwa, S., Sacks, H. et al. (1983) Quantitative CSF IgG measurements in multiple sclerosis and other neurologic diseases. An update. Arch. Neurol., 40, 409–13.PubMedGoogle Scholar
  24. 24.
    Caroscio, J.T., Kochwa, S., Sacks, H. et al. (1986) Quantitative cerebrospinal fluid IgG measurements as a marker of disease activity in multiple sclerosis. Arch. Neurol., 43, 1129–31.PubMedGoogle Scholar
  25. 25.
    Perkin, G.D., Sethi, K. and Muller, B.R. (1983) IgG ratios and oligoclonal IgG in multiple sclerosis and other neurological disorders. J. Neurol. Sci., 60, 325–36.PubMedGoogle Scholar
  26. 26.
    Kolar, O.J., Rice, P.H., Jones, F.H. et al. (1980) Cerebrospinal fluid immunoelectrophoresis in multiple sclerosis. J. Neurol. Sci., 47, 221–30.PubMedGoogle Scholar
  27. 27.
    Kostulas, V.K. and Link, H. (1982) Agarose isoelectric focusing of unconcentrated CSF and radioimmunofixation for detection of oligoclonal bands in patients with multiple sclerosis and other neurological diseases. J. Neurol. Sci., 54, 117–27.PubMedGoogle Scholar
  28. 28.
    Laurenzi, M.A., Mavra, M., Kam-Hansen, S. and Link, H. (1980) Oligocloncal IgG and free light chains in multiple sclerosis demonstrated by thin-layer polyacrylamide gel isoelectric focusing and immunofixation. Ann. Neurol., 8, 241–7.PubMedGoogle Scholar
  29. 29.
    Thompson, E.J., Kaufmann, P. and Rudge, P. (1983) Sequential changes in oligoclonal patterns during the course of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 46, 115–18.PubMedGoogle Scholar
  30. 30.
    Easmark, B. and Sidén, A. (1984) Isoelectric focusing of CSF proteins and the future evolution of multiple sclerosis: a clinical follow-up. J. Neurol., 231, 117–21.Google Scholar
  31. 31.
    Kostulas, V.K., Henriksson, A. and Link, H. (1986) Monosymptomatic sensory symptoms and cerebrospinal fluid immunoglobulin levels in relation to multiple sclerosis. Arch. Neurol., 43, 447–51.PubMedGoogle Scholar
  32. 32.
    Perkin, G.D. and Muller, B.K. (1987) The influence of abnormal IgG ratios in the CSF on further development of the disease in single lesion multiple sclerosis in Multiple Sclerosis. Immunological, diagnostic and therapeutic aspects. Eds F.C. Rose and R. Jones. John Libbey, London, Paris pp 115–119.Google Scholar
  33. 33.
    Grimaldi, L.M.E., Roos, R.P., Nalefski, E.A. and Arnason, B.G.W. (1985) Oligoclonal IgA bands in multiple sclerosis and subacute sclerosing panencephalitis. Neurology, 35, 813–17.PubMedGoogle Scholar
  34. 34.
    Rudick, R.A., Jacobs, L., Kinkel, P.R. and Kinkel, W.R. (1986) Isolated idiopathic optic neuritis. Analysis of free K-light chains in cerebrospinal fluid and correlation with nuclear magnetic resonance findings. Arch. Neurol., 43, 456–8.PubMedGoogle Scholar
  35. 35.
    Patterson, V.H. and Heron, J.R. (1980) Visual field abnormalities in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 43, 205–8.PubMedGoogle Scholar
  36. 36.
    Meienberg, O., Flammer, J. and Ludin, H.-P. (1982) Subclinical visual field defects in multiple sclerosis. Demonstration and quantification with automated perimetry and comparison with visual evoked potentials. J. Neurol., 227, 125–33.Google Scholar
  37. 37.
    Halliday, A.M., McDonald, W.I. and Mushin, J. (1973) Visual evoked response in diagnosis of multiple sclerosis. Br. Med. J., 4, 661–4.PubMedGoogle Scholar
  38. 38.
    Aminoff, M.J. and Ochs, A.L. (1981) Pattern-onset visual evoked potentials in suspected multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 44, 608–14.PubMedGoogle Scholar
  39. 39.
    Hennerici, M., Wenzel, D. and Freund, H.-J. (1977) The comparison of small-sized rectangle and checkerboard stimulation for the evaluation of delayed visual evoked responses in patients suspected of multiple sclerosis. Brain, 100, 119–36.PubMedGoogle Scholar
  40. 40.
    Hammond, S.R. and Yiannikas, C. (1986) Contribution of pattern reversal foveal and half-field stimulation to analysis of VEP abnormalities in multiple sclerosis. Electroencephalogr. Clin. Neurophysiol., 64, 101–18.PubMedGoogle Scholar
  41. 41.
    Regan, D., Bartol, S., Murray, T.J. and Beverley, K.I. (1982) Spatial frequency discrimination in normal vision and in patients with multiple sclerosis. Brain, 105, 735–54.PubMedGoogle Scholar
  42. 42.
    Kupersmith, M.J., Nelson, J.I., Seiple, W.H. et al. (1983) The 20/20 eye in multiple sclerosis. Neurology, 33, 1015–20.PubMedGoogle Scholar
  43. 43.
    Camisa, J., Mylin, L.H. and Bodis-Wollner, I. (1981) The effect of stimulus orientation on the visual evoked potential in multiple sclerosis. Ann. Neurology, 10, 532–9.Google Scholar
  44. 44.
    Kempster, P.A., Iansek, R., Balla, J.I. et al. (1987) Value of visual evoked response and oligoclonal bands in cerebrospinal fluid in diagnosis of spinal multiple sclerosis. Lancet, 1, 769–71.PubMedGoogle Scholar
  45. 45.
    Perkin, G.D. and Rose, F.C. (1979) Optic Neuritis and its Differential Diagnosis. Oxford University Press, Oxford.Google Scholar
  46. 46.
    Regan, D. and Neima, D. (1984) Visual fatigue and visual evoked potentials in multiple sclerosis, glaucoma, ocular hypertension and Parkinson’s disease. J. Neurol. Sci., 47, 673–8.Google Scholar
  47. 47.
    Robinson, K. and Rudge, P. (1980) The use of the auditory evoked potential in the diagnosis of multiple sclerosis. J. Neurol. Sci., 45, 235–44.PubMedGoogle Scholar
  48. 48.
    Chiappa, K.H., Harrison, J.L., Brooks, E.B. and Young, R.R. (1980) Brainstem auditory evoked responses in 200 patients with multiple sclerosis. Ann. Neurol., 17, 135–43.Google Scholar
  49. 49.
    Prasher, D.K., Sainz, M. and Gibson, W.P.R. (1982) Binaural voltage summation of brain stem auditory evoked potentials: an adjunct to the diagnostic criteria for multiple sclerosis. Ann. Neurol., 11, 86–91.PubMedGoogle Scholar
  50. 50.
    Kayamori, R., Dickins, Q.S., Yamada, T. and Kimura, J. (1984) Brainstem auditory evoked potential and blink reflex in multiple sclerosis. Neurol., 34, 1318–23.Google Scholar
  51. 51.
    Kofler, B., Oberascher, G. and Pommer, B. (1984) Brain-stem involvement in multiple sclerosis: a comparison between brain-stem auditory evoked potentials and the acoustic stapedius reflex. J. Neurol., 231, 145–7.PubMedGoogle Scholar
  52. 52.
    Sanders, E.A.C.M., Ongerboer de Visser, B.W., Barendswaard, E.C. and Arts, R.J.H.M. (1985) Jaw, blink and corneal reflex latencies in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 48, 1284–9.PubMedGoogle Scholar
  53. 53.
    Abbruzzese, G., Cocito, L., Ratto, S. et al. (1981) A reassessment of sensory evoked potential parameters in multiple sclerosis: a discriminant analysis approach. J. Neurol. Neurosurg. Psychiatry, 44, 133–9.PubMedGoogle Scholar
  54. 54.
    Chiappa, K.H. (1980) Pattern shift visual, brainstem auditory, and short-latency somatosensory evoked potentials in multiple sclerosis. Neurology, 30, 110–23.PubMedGoogle Scholar
  55. 55.
    Walsh, J.C., Garrick, R., Cameron, J. and McLeod, J.G. (1982) Evoked potential changes in clinically definite multiple sclerosis: a two year follow up study. J. Neurol. Neurosurg. Psychiatry, 45, 494–500.PubMedGoogle Scholar
  56. 56.
    Phillips, K.R., Potvin, A.R., Syndulko, K. et al. (1983) Multimodality evoked potentials and neurophysiological tests in multiple sclerosis. Arch. Neurol., 40, 159–64.PubMedGoogle Scholar
  57. 57.
    Cowan, J.M.A., Rothwell, J.C., Dick, J.P.R. et al. (1984) Abnormalities in central motor pathway conduction in multiple sclerosis. Lancet, 11, 304–7.Google Scholar
  58. 58.
    Snooks, S.J. and Swash, M. (1985) Motor conduction velocity in the human spinal cord: slowed conduction in multiple sclerosis and radiation myelopathy. J. Neurol. Neurosurg. Psychiatry., 48, 1135–9.PubMedGoogle Scholar
  59. 59.
    Hess, C.W., Mills, K.R. and Murray, N.M.F. (1986) Measurement of central motor conduction in multiple sclerosis by magnetic brain stimulation. Lancet, 11, 355–8.Google Scholar
  60. 60.
    Sanders, E.A.C.M., Reulen, J.P.H. and Hogenhuis, L.A.H. (1984) Central nervous system involvement in optic neuritis. J. Neurol. Neurosurg. Psychiatry, 47, 241–9.PubMedGoogle Scholar
  61. 61.
    Reisner, T. and Maida, E. (1980) Computerized tomography in multiple sclerosis. Arch. Neurol., 37, 475–7.PubMedGoogle Scholar
  62. 62.
    Loizou, L.A., Rolfe, E.B. and Hewazy, H. (1982) Cranial computed tomography in the diagnosis of multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 45, 905–12.PubMedGoogle Scholar
  63. 63.
    Barrett, L., Drayer, B. and Shin, C. (1985) High-resolution computed tomography in multiple sclerosis. Ann. Neurol., 17, 33–8.PubMedGoogle Scholar
  64. 64.
    Lodder, J., de Weerd, A.W., Koetsier, J.C. and van der Lugt, P.J.M. (1983) Computed tomography in acute cerebral multiple sclerosis. Arch. Neurol., 40, 320–2.PubMedGoogle Scholar
  65. 65.
    Young, I.R., Hall, A.S., Pallis, C.A. et al. (1981) Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet, 11, 1063–6.Google Scholar
  66. 66.
    Lukes, S.A., Crooks, L.E., Aminoff, M.J. et al. (1983) Nuclear magnetic resonance imaging in multiple sclerosis. Ann. Neurol., 13, 592–601.PubMedGoogle Scholar
  67. 67.
    Farlow, M.R., Markand, O.N., Edwards, M.K. et al. (1986) Multiple sclerosis: magnetic resonance imaging, evoked responses, and spinal fluid electrophoresis. Neurology, 36, 828–31.PubMedGoogle Scholar
  68. 68.
    Jacobs, L., Kinkel, W.R., Polachini, I. and Kinkel, R.P. (1986) Correlation of nuclear magnetic resonance imaging, computerized tomography, and clinical profiles in multiple sclerosis. Neurology, 36, 27–34.PubMedGoogle Scholar
  69. 69.
    Runge, V.M., Price, A.C., Kirschner, H.S. et al. (1984) Magnetic resonance imaging of multiple sclerosis: a study of pulse-technique efficiency. Am. J. Roentgenol., 143, 1015–26.Google Scholar
  70. 70.
    Miller, D.H., Johnson, G., McDonald, W.I. et al. (1986) Detection of optic nerve lesions in optic neuritis with magnetic resonance imaging. Lancet, 1, 1490–1.PubMedGoogle Scholar
  71. 71.
    Jacobs, L., Kinkel, P.R. and Kinkel, W.R. (1986) Silent brain lesions in patients with isolated idiopathic optic neuritis. A clinical and nuclear magnetic resonance imaging study. Arch. Neurol., 43, 452–5.PubMedGoogle Scholar
  72. 72.
    Johns, K., Lavin, P., Elliot, J.H. and Partain, L. (1986) Magnetic resonance imaging of the brain in isolated optic neuritis. Arch. Ophthalmol., 104, 1486–8.PubMedGoogle Scholar
  73. 73.
    Ormerod, I.E.C., Bronstein, A., Rudge, P. et al. (1986) Magnetic resonance imaging in clinically isolated lesions of the brain stem. J. Neurol. Neurosurg. Psychiatry, 49, 737–43.PubMedGoogle Scholar
  74. 74.
    Rudick, R.A., Schiffer, R.B., Schwetz, K.M. and Herndon, R.M. (1986) Multiple sclerosis. The problem of incorrect diagnosis. Arch. Neurol., 43, 578–83.PubMedGoogle Scholar
  75. 75.
    Beller, A.J., Sahar, A. and Praiss, I. (1973) Brain abscess. Review of 89 cases over a period of 30 years. J. Neurol. Neurosurg. Psychiatry, 36, 757–68.PubMedGoogle Scholar
  76. 76.
    Yang, S.-Y. (1981) Brain abscess: a review of 400 cases. J. Neurosurg., 55, 794–9.PubMedGoogle Scholar
  77. 77.
    Garfield, J. (1969) Management of supratentorial intracranial abscess: a review of 200 cases. Br. Med. J., 2, 7–11.PubMedGoogle Scholar
  78. 78.
    Bhandari, Y.S. and Sarkari, N.B.S. (1970) Subdural empyema. A review of 37 cases. J. Neurosurg., 32, 35–9.PubMedGoogle Scholar
  79. 79.
    Davis, D.O. and Potchen, E.J. (1970) Brain scanning and intracranial inflammatory disease. Radiology, 95, 345–6.PubMedGoogle Scholar
  80. 80.
    Brewer, N.S., MacCarty, C.S. and Wellman, W.E. (1975) Brain abscess: a review of recent experience. Ann. Intern. Med., 82, 571–6.PubMedGoogle Scholar
  81. 81.
    Weisberg, L.A. (1980) Cerebral computerized tomography in intra-cranial inflammatory disorders. Arch. Neurol., 37, 137–42.PubMedGoogle Scholar
  82. 82.
    Britt, R.H. and Enzmann, D.R. (1983) Clinical stages of human brain abscesses on serial CT scans after contrast infusion. Computerized tomographic, neuropathological, and clinical correlations. J. Neurosurg., 59, 972–89.PubMedGoogle Scholar
  83. 83.
    Dunker, R.O. and Khakoo, R.A. (1981) Failure of computed tomo-graphic scanning to demonstrate subdural empyema. J. Am. Med. Assoc., 246, 1116–18.Google Scholar
  84. 84.
    Mauser, H.W., van Huffelen, A.C. and Tulleken, C.A.F. (1986) The EEG in the diagnosis of subdural empyema. Electroencephalogr. Clin. Neurophysiol., 64, 511–16.PubMedGoogle Scholar
  85. 85.
    Sharif, H.S. and Ibrahim, A. (1982) Intracranial epidural abscess. Br. J. Radiol., 55, 81–4.PubMedGoogle Scholar
  86. 86.
    Bashir, R., Zuheir Al-Kawi, M. and Harder, E.J. (1985) Nervous system brucellosis: diagnosis and treatment. Neurology, 35, 1576–81.PubMedGoogle Scholar
  87. 87.
    Shakir, R.A., Al-Din, A.S.N., Araj, G.F. et al. (1987) Clinical categories of neurobrucellosis. A report on 19 cases. Brain, 110, 213–24.PubMedGoogle Scholar
  88. 88.
    Simon, R.P. (1985) Neurosyphilis. Arch. Neurol., 42, 606–13.PubMedGoogle Scholar
  89. 150.
    Multiple sclerosis. CNS infectionGoogle Scholar
  90. 89.
    Kinnunen, E. and Hillbom, M. (1986) The significance of cerebrospinal fluid routine screening for neurosyphilis. J. Neurol. Sci., 75, 205–11.PubMedGoogle Scholar
  91. 90.
    Dans, P.E., Cafferty, L., Otter, S.E. and Johnson, R.J. (1986) Inappropriate use of the cerebrospinal fluid venereal disease research laboratory (VDRL) test to exclude neurosyphilis. Ann. Intern. Med., 104, 86–9.PubMedGoogle Scholar
  92. 91.
    Harrigan, E.P., McLaughlin, T.J. and Feldman, R.G. (1984) Transverse myelitis due to meningovascular syphilis. Arch. Neurol., 41, 337–8.PubMedGoogle Scholar
  93. 92.
    Conrad, B., Benecke, R., Müsers, H. et al. (1983) Visual evoked potentials in neurosyphilis. J. Neurol. Neurosurg. Psychiatry, 46, 23–7.PubMedGoogle Scholar
  94. 93.
    Cobb, W. and Hill, D. (1950) Electroencephalogram in subacute progressive encephalitis. Brain, 73, 392–404.PubMedGoogle Scholar
  95. 94.
    Krawiecki, N.S., Dyken, P.R., El Gammal, T. et al. (1984) Computed tomography of the brain in subacute sclerosing panencephalitis. Ann.’ Neurol., 15, 489–93.PubMedGoogle Scholar
  96. 95.
    Bale, J.F. Jr (1984) Human cytomegalovirus infection and disorders of the nervous system. Arch. Neurol., 41, 310–20.PubMedGoogle Scholar
  97. 96.
    Levy, J.D., Cottingham, K.L., Campbell, R.J. et al. (1986) Progressive multifocal leukoencephalopathy and magnetic resonance imaging. Ann. Neurol., 19, 399–401.PubMedGoogle Scholar
  98. 97.
    Little, B.W., Brown, P.W., Rodgers-Johnson, P. et al. (1986) Familial myoclonic dementia masquerading as Creutzfeldt—Jakob disease. Ann. Neurol., 20, 231–9.PubMedGoogle Scholar
  99. 98.
    May, W.W. (1968) Creutzfeldt—Jakob disease. Acta Neurol. Scand., 44, 1–32.PubMedGoogle Scholar
  100. 99.
    Abbott, J. (1959) The EEG in Jakob—Creutzfeldt’s disease. Electroencephalogr. Clin. Neurophysiol., 11, 184–5.Google Scholar
  101. 100.
    Chiofalo, N., Fuentes, A. and Gâlvez, S. (1980) Serial EEG findings in 27 cases of Creutzfeldt—Jakob disease. Arch. Neurol., 37, 143–5.PubMedGoogle Scholar
  102. 101.
    Gâlvez, S. and Cartier, L. (1984) Computed tomography findings in 15 cases of Creutzfeldt—Jakob disease with histological verification. J. Neurol. Neurosurg. Psychiatry, 47, 1244–6.PubMedGoogle Scholar
  103. 102.
    Harrington, M.G., Merril, C.R., Asher, D.M. and Gajdusek, D.C. (1986) Abnormal proteins in the cerebrospinal fluid of patients with Creutzfeldt—Jakob disease. N. Engl. J. Med., 315, 279–82.PubMedGoogle Scholar
  104. 103.
    Brown, P., Rodgers-Johnson, P., Cathala, F. et al. (1984) Creutzfeldt Jakob disease of long duration: clinico-pathological characteristics, transmissibility, and differential diagnosis. Ann. Neurol., 16, 295–304.PubMedGoogle Scholar
  105. 104.
    Brown, P., Coker-Vann, M., Pomeroy, K. et al. (1986) Diagnosis of Creutzfeldt—Jakob disease by western blot identification of marker protein in human brain tissue. N. Engl. J. Med., 314, 547–51.PubMedGoogle Scholar
  106. 105.
    Walsh, T.J., Hier, D.B. and Caplan, L..R. (1985) Aspergillosis of the central nervous system: clinico-pathological analysis of 17 patients. Ann. Neurol., 18, 574–82.PubMedGoogle Scholar
  107. 106.
    Beal, M.F., O’Carroll, C.P., Kleinman, G.M. and Grossman, R.I. (1982) Aspergillosis of the nervous system. Neurology, 32, 473–9.PubMedGoogle Scholar
  108. 107.
    Garcia, C.A., Weisberg, L.A. and Lacorte, W.S.J. (1985) Cryptococcal intracerebral mass lesions: CT-pathologic considerations. Neurology, 35, 731–4.PubMedGoogle Scholar
  109. 108.
    Scrimgeour, E.M. and Gajdusek, D.C. (1985) Involvement of the central nervous system in Schistosoma mansoni and S. haematobium infection. A review. Brain, 108, 1023–38.PubMedGoogle Scholar
  110. 109.
    McCormick, G.F., Zee, C.-S. and Heiden, J. (1982) Cysticercosis cerebri. Review of 127 cases. Arch. Neurol., 39, 534–9.PubMedGoogle Scholar
  111. 110.
    Torrealba, G., Villar, S.D., Tagle, P. et al. (1984) Cysticercosis of the central nervous system: clinical and therapeutic considerations. J. Neurol. Neurosurg. Psychiatry, 47, 784–90.PubMedGoogle Scholar
  112. 111.
    Miller, B., Goldberg, M.A., Heiner, D. et al. (1984) A new immunologic test for CNS cysticercosis. Neurology, 34, 695–7.PubMedGoogle Scholar
  113. 112.
    Estrada, J.J. and Kuhn, R.E. (1985) Immunochemical detection of antigens of larval Taenia solium and anti-larval antibodies in the cerebrospinal fluid of patients with neurocysticercosis. J. Neurol. Sci., 71, 39–48.PubMedGoogle Scholar
  114. 113.
    Minguetti, G. and Ferreira, M.V.C. (1983) Computed tomography in neurocysticercosis. J. Neurol. Neurosurg. Psychiatry, 46, 936–42.PubMedGoogle Scholar
  115. 114.
    Snider, W.D., Simpson, D.M., Nielsen, S. et al. (1983) Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann. Neurol., 14, 403–18.PubMedGoogle Scholar
  116. 115.
    Navia, B.A., Petito, C.K., Gold, J.W.M. et al. (1986) Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients. Ann. Neurol., 19, 224–38.PubMedGoogle Scholar
  117. 116.
    Alonso, R., Heiman-Patterson, T. and Mancall, E.L. (1984) Cerebral toxoplasmosis in acquired immune deficiency syndrome. Arch. Neurol., 41, 321–3.PubMedGoogle Scholar
  118. 117.
    Horowitz, S.L., Bentson, J.R., Benson, F. et al. (1983) CNS toxoplasmosis in acquired immunodeficiency syndrome. Arch. Neurol., 40, 649–52.PubMedGoogle Scholar
  119. 118.
    Luft, B.J., Brooks, R.G., Conley, F.K. et al. (1984) Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome. J. Am. Med. Assoc., 252, 913–17.Google Scholar

Copyright information

© G.D. Perkin 1988

Authors and Affiliations

  • G. D. Perkin
    • 1
  1. 1.Department of NeurologyCharing Cross HospitalLondonUK

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