Multiple sclerosis CNS infection

  • G. D. Perkin
Part of the Diagnostic Tests Series book series (DTS)


For many patients, the diagnosis of multiple sclerosis is evident from their clinical characteristics. A remitting and relapsing illness in a young adult with signs reflecting scattered white matter dysfunction, hardly requires investigation, though the picture so defined is not unique to multiple sclerosis. Greater uncertainty occurs in the early course of the illness before a remitting and relapsing pattern has been established, or where the disability is progressive from the outset. Previous classifications of the disease allowed for such uncertainties by designating definite, probable or possible categories [1] or definite, early probable/latent and progressive probable/possible cases [2]. The latter criteria include data based on electrophysiological studies. More recently, a classification incorporating CSF data has been introduced [3]. There are no tests which infallibly identify patients with multiple sclerosis. Certainly CSF changes, for example oligoclonal IgG, and abnormalities of central conduction time are seen in other neurological disorders. Even the demonstration of paraventricular pathology by magnetic resonance imagery does not allow a certain diagnosis, since identical appearances are encountered in some patients with cerebrovascular disease [4].


Multiple Sclerosis Optic Neuritis Visual Evoke Potential Nuclear Magnetic Resonance Imaging Subdural Empyema 
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Copyright information

© G.D. Perkin 1988

Authors and Affiliations

  • G. D. Perkin
    • 1
  1. 1.Department of NeurologyCharing Cross HospitalLondonUK

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