Repair of X-ray damage I: Repair of chromosome breaks

  • Charlotte Auerbach


We have seen in Chapter 2 that chromosome breakage may have one of three consequences. (1) The breaks rejoin in the old order — restitution. (2) The breaks rejoin in a new, wrong order — formation of rearrangements. (3) The breaks remain open. This leads to either terminal deletion or chromosome loss via a breakage-fusion-bridge cycle. Since there is no essential difference between the types of rejoining that result in restitution or in the formation of rearrangements, we shall consider both as forms of repair. Sobels has introduced the useful term ‘misrepair’ for the production of rearrangements.


Chromosome Breakage Potassium Cyanide Terminal Deletion Lampbrush Chromosome Aberration Frequency 
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© Charlotte Auerbach 1976

Authors and Affiliations

  • Charlotte Auerbach
    • 1
  1. 1.Institute of Animal GeneticsUniversity of EdinburghUK

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