Although oesophageal atresia and tracheo-oesophageal fistula are relatively common birth defects, little is known of their genetics and epidemiology. Most cases have been sporadic with occasional reports of familial occurrence. On the basis of the familial reports, some authors have concluded that genetic factors are important (Il’ina and Lurie, 1984; Pfeiffer, 1986). Other reports based on retrospective studies have suggested environmental and teratogenic factors (Warkany et al., 1948; Ingalls and Prindle, 1949) with no conclusive evidence for any specific aetiological agent. Reports on the experience of various centres have concentrated on the outcome of the surgical management of indexed cases. Population and family studies have been lacking.
KeywordsEsophageal Atresia Pyloric Stenosis Fanconi Syndrome Familial Occurrence Oesophageal Atresia
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