Antineutrophil cytoplasmic antibodies (ANCA): current perspectives

  • C. G. M. Kallenberg

Abstract

The idiopathic systemic vasculitides constitute a group of disorders characterized by more or less widespread inflammation of vessel walls generally without an underlying cause or an associated condition. The idiopathic vasculitides are traditionally grouped according to the size of the vessels involved and the histopathology of the inflammatory process. Such a classification is shown in Table 4.1. A recent modification of this scheme based on a more strict application of histopathological criteria with respect to the size of the vessels involved [1], is given in Table 4.2. The definitions and classification of the vasculitides demonstrate that histopathological findings are essential for making a diagnosis of a distinct vasculitic disorder. In clinical practice, however, pathognomonic histopathological findings are hard to obtain in most patients suspected of vasculitis, even in cases where multiple biopsies have been performed [2]. For this and other reasons, classification criteria have been designed by the American College of Rheumatologists (ACR) that are mainly based on clinical signs and symptoms [3]. These criteria can be used for the classification of patients who have al.ready have been proved to have vasculitis.

Keywords

Arthritis Corticosteroid Titration Serine Vasculitis 

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© Springer Science+Business Media Dordrecht 1996

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  • C. G. M. Kallenberg

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