Mixed cryoglobulinemia: the role of HCV and organ-specific antibodies

  • S. Bombardieri
  • A. Tavoni
  • M. Mosca
  • L. La Civita
  • M. P. Dolcher
  • F. Lombardini
  • P. Migliorini
  • C. Ferri

Abstract

The term ‘cryoglobulin’ was introduced to define a group of proteins which have the common property of forming a reversible precipitate or gel in the cold [1]. Three groups of cryoglobulins have been identified. Type I cryoglobulins are monoclonal, the most common one being immunoglobulin M (IgM), a protein associated with immunoprolifera-tive disorders, such as Waldenstrom’s macroglobulinemia, lymphopro-liferative disorders and multiple myeloma.

Keywords

Toxicity Arthritis Hepatitis Filtration Europe 

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References

  1. 1.
    Lospalluto, J., Dorward, B., Miller, W. Jr. and Ziff, M. (1962) Cryoglobulinemia based on interaction between a gamma macroglobulin and 7S gammaglobulin. Am. J. Med., 32, 142.PubMedCrossRefGoogle Scholar
  2. 2.
    Brouet, J.C., Clouvel, J.P., Danon, F. et al. (1974) Biologic and clinical significance of cryoglobulins. Am. J. Med., 57, 775.PubMedCrossRefGoogle Scholar
  3. 3.
    Meltzer, M. and Franklin, E.C. (1966) Cryoglobulinemia: a study of twenty-nine patients. I. IgG and IgM cryoglobulins and factors affecting cryopreci-pitability. Am. J. Med., 40, 828.PubMedCrossRefGoogle Scholar
  4. 4.
    Gorevic, P.D., Kassab, H.J., Levo, Y. et al. (1980) Mixed cryoglobulinemia: clinical aspects and long term follow-up of 40 patients. Am. J. Med., 69, 287.PubMedCrossRefGoogle Scholar
  5. 5.
    Gorevic, P.D. and Frangione, B. (1991) Mixed cryoglobulinemia cross reactive idiotypes: implication for relationships of MC to rheumatic and lymphopro-lipherative diseases. Semin. Hematol., 28, 79.PubMedGoogle Scholar
  6. 6.
    Migliorini, P., Bombardieri, S., Castellani, A. and Ferrara, G.B. (1981) HLA antigens in essential mixed cryoglobulinemia. Arthritis Rheum., 24, 932.PubMedCrossRefGoogle Scholar
  7. 7.
    Zignego, A.L., Macchia, D., Monti, M. et al. (1992) Infection of peripheral mononuclear blood cells by hepatitis C virus. J. Hepatol, 15, 382.PubMedCrossRefGoogle Scholar
  8. 8.
    Bombardieri, S., Ferri, C., Di Munno, O. and Pasero, G. (1979) Liver involvement in essential mixed cryoglobulinemia. Ric. Clin. Lab., 9, 361.PubMedGoogle Scholar
  9. 9.
    Inman, R.D., Hodge, M., Johnston, M.E. et al. (1986) Arthritis, vasculitis and cryoglobulinemia associated with relapsing hepatitis A virus infection. Ann. Intern. Med., 105, 700.PubMedCrossRefGoogle Scholar
  10. 10.
    Fiorini, G.F., Sinico, R.A., Winearls, C. et al. (1988) EBV infection in patients with type 2 essential MC. Clin. Immunol. Immunopathol., 47, 262.PubMedCrossRefGoogle Scholar
  11. 11.
    Realdi, G., Alberti, A., Rigoli, A. and Tremolada, F. (1974) Immune complexes and Australia antigen in cryoglobulinemic sera. Z. Immunitatsfortsch Exp. Klin. Immunol., 147, 114.Google Scholar
  12. 12.
    Galli, M. and the GISC members (1991) Cryoglobulinemia and serological markers of hepatitis viruses. Lancet, 758. Google Scholar
  13. 13.
    Hosein, B., Fang, C.T., Popowskj, M.A. et al. (1991) Improved serodiagnosis of HCV infection with synthetic peptide antigen from capside protein. Proc. Nat. Acad. Sci. USA, 88, 3647.PubMedCrossRefGoogle Scholar
  14. 14.
    Pascual, M., Perrin, L., Giostra, E. and Schifer, J.A. (1990) Hepatitis C virus in patients with cryoglobulinemia type 2. J. Infect. Dis., 162, 569.PubMedCrossRefGoogle Scholar
  15. 15.
    Ferri, C., Greco, F., Longombardo, G. et al. (1991) Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. Arthritis Rheum., 34, 1606–10.PubMedCrossRefGoogle Scholar
  16. 16.
    Ferri, C., Greco, F., Longombardo, G. et al. (1991) Antibodies against hepatitis C virus in mixed cryoglobulinemia patients. Infection, 19, 417–20.PubMedCrossRefGoogle Scholar
  17. 17.
    Ferri, C., Greco, F., Longombardo, G., et al. (1991) Association between hepatitis C virus and mixed cryoglobulinemia. Clin. Exp. Rheumatol., 9, 621–4.PubMedGoogle Scholar
  18. 18.
    Bambara, L.M., Biasi, D., Caramaschi, P. et al. (1991) Cryoglobulinemia and hepatitis C virus infection. Clin. Exp. Rheumatol., 9, 95.Google Scholar
  19. 19.
    Harle, J.R., Disdier, P. and Durand, J.M. (1991) Cryoglobuliéme mixed au cours de l’infection par le virus de l’hepatite C. Dix cas. Presse Méd., 20, 1233.PubMedGoogle Scholar
  20. 20.
    Disdier, P., Harle, J.R. and Weiller, P.J. (1991) Cryoglobulinemia and hepatitic infection. Lancet, 338, 1151.PubMedCrossRefGoogle Scholar
  21. 21.
    Agnello, V., Chung, R.T., Dienstag, J.L. et al. (1991) Evidence for the association of hepatitic C virus with essential mixed cryoglobilinemia. Arthritis Rheum., 34 (Suppl. 9), S45, Abstract 78.Google Scholar
  22. 22.
    Agnello, V, . Chung, R.T. and Kaplan, L.M. (1992) A role for hepatitis C virus infection in type 2 cryoglobulinemia. N. Engl. J. Med., 327, 1490.PubMedCrossRefGoogle Scholar
  23. 23.
    Ferri, C., Longombardo, G., La Civita, L., Bombardieri, S. et al. (1992) Hepatitis C virus, autoimmune liver diseases and cryoglobulinemic hepatitis. J. Hepatol., 16, 242–3.PubMedCrossRefGoogle Scholar
  24. 24.
    Ferri, C., Longombardo, G., La Civita, L. et al. (1992) Hepatitis C virus infection in mixed cryoglobulinemia. Gastroentérology, 103, 1108–10.Google Scholar
  25. 25.
    Ferri, C., La Civita, L., Longombardo, G. et al. (1993) Hepatitis C virus and mixed cryoglobulinemia. Eur. J. Clin. Invest., 23, 399–405.PubMedCrossRefGoogle Scholar
  26. 26.
    Ferri, C., Monti, M., La Civita, L. et al. (1993) Infection of peripheral mononuclear cells by hepatitis C virus in mixed cryoglobulinemia. Blood, 82, 3701–4.PubMedGoogle Scholar
  27. 27.
    Abel, G., Zhang, Q. and Agnello, V. (1993) Hepatitis C virus infection in type II mixed cryoglobulinemia. Arthritis Rheum., 36, 1341–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Monteverde, A., Rivano, M.T., Allegra, G.C. et al. (1988) Essential mixed cryoglobulinemia, type II: a manifestation of a low grade malignant lymphoma? Acta Haematol. (Basel), 79, 20.CrossRefGoogle Scholar
  29. 29.
    Bombardieri, S., Puccetti, A. and Pilo, A. (1989) A method for retracing the putative antigen/antibody ratio of immune complexes in biological fluids. Clin. Exp. Rheumatol., 7/S-3 (Suppl), 109.Google Scholar
  30. 30.
    Bombardieri, S., Caponi, L., Pilo, A. et al. (1989) Changes in the putative antigen/antibody ratio of circulating immune complexes in mixed cryoglobulinemia and systemic lupus erythematosus following selected removal of macromolecules. Int. J. Art. Org., 12/S4, 87.Google Scholar
  31. 31.
    Vitali, C., Tavoni, S. and Bombardieri, S. (1984) La fonction réticulo-endothé-liale splénique dans les maladies à complexes immuns. Médecine Hyg., 42, 109.Google Scholar
  32. 32.
    Ferri, C., Pietrogrande, M., Cecchetti, R. et al. (1989) Low-antigen-content diet in the treatment of mixed cryoglobulinemia patients. Am. J. Med., 87, 519.PubMedCrossRefGoogle Scholar
  33. 33.
    Schifferli, J.A., Morris, S.M., Dash, A. and Peters, D.K. (1981) Complement mediated solubilization in patients with systemic lupus erythematosus, nephritis or vasculitis. Clin. Exp. Immunol., 46, 557.PubMedGoogle Scholar
  34. 34.
    Schifferli, J.A., Wood, P. and Peters, D.K. (1982) Complement mediated inhibition of immune precipitation I. Role of the classical and al.ternative pathways. Clin. Exp. Immunol., 47, 555.PubMedGoogle Scholar
  35. 35.
    Balestrieri, G., Tincani, A., Migliorini, P. et al. (1984) Inhibitory effect of IgM rheumatoid factor on immune complex solubilization capacity and inhibition of immune precipitation. Arthritis Rheum., 27, 1130.PubMedCrossRefGoogle Scholar
  36. 36.
    Ferri, C., Mannini, L., Bartoli, V. et al. (1990) Blood viscosity and filtration abnormalities in mixed cryoglobulinemia patients. Clin. Exp. Rheumatol., 8, 271.PubMedGoogle Scholar
  37. 37.
    Ferri, C., La Civita, L., Cirafisi, C. et al. (1992) Peripheral neuropathy in mixed cryoglobulinemia: clinical and electro-physical investigations. J. Rheumatol., 19, 889–95.PubMedGoogle Scholar
  38. 38.
    Kefalides, N.A., Pegg, M.T., Ohno, N. et al. (1986) Antibodies to basement membrane collagen and to laminin are present in sera from patients with post-streptococcal glomerulonephritis. J. Exp. Med., 163, 588.PubMedCrossRefGoogle Scholar
  39. 39.
    Dolcher, M.P., Marchini, B., Sabbatini, A. et al. (in press) Autoantibodies from mixed cryoglobulinemia patients bind glomerular antigens. Clin. Exp. Immunol., (In press).Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1996

Authors and Affiliations

  • S. Bombardieri
  • A. Tavoni
  • M. Mosca
  • L. La Civita
  • M. P. Dolcher
  • F. Lombardini
  • P. Migliorini
  • C. Ferri

There are no affiliations available

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