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Evaluation of drug response

  • Chapter
Therapeutics in Rheumatology

Abstract

Many of the rheumatic diseases exhibit a number of different clinical signs and symptoms. These are frequently related to multiple anatomical sites and in addition, there may be abnormalities in laboratory tests, on radiographic examination and in other specialized investigations. As a result ’batteries’ of assessments have evolved and the reader of clinical trial reports on antirheumatic drugs is usually confronted with a complex array of data, comprising various individual measurements, both subjective and objective. It is thus difficult to obtain a comprehensive evaluation of therapy and even when the individual measurements are combined to produce composite indices the overall picture is often far from clear. This is in sharp contrast with many other disorders; for example, hypertension in which one primary measurement is used, both in clinical trials and clinical practice, to assess response to drug therapy.

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Authors
  1. R. Madhok
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  2. H. A. Capell
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Editors and Affiliations

  1. Sheffield Centre for Rheumatic Diseases, Nether Edge Hospital, Sheffield, UK

    J. M. H. Moll BSc DM PhD FRCP (Consultant physician in Rheumatology and Head, Honorary Clinical Lecturer in Rheumatic Diseases) (Consultant physician in Rheumatology and Head, Honorary Clinical Lecturer in Rheumatic Diseases)

  2. University of Sheffield, UK

    J. M. H. Moll BSc DM PhD FRCP (Consultant physician in Rheumatology and Head, Honorary Clinical Lecturer in Rheumatic Diseases) (Consultant physician in Rheumatology and Head, Honorary Clinical Lecturer in Rheumatic Diseases)

  3. General Infirmary at Leeds, University Department of Medicine, UK

    H. A. Bird MA MD FRCP (Lecturer in Rheumatology, Honorary Consultant Rheumatologist) (Lecturer in Rheumatology, Honorary Consultant Rheumatologist)

  4. General Infirmary at Leeds and Royal Bath Hospital, Harrogate, UK

    H. A. Bird MA MD FRCP (Lecturer in Rheumatology, Honorary Consultant Rheumatologist) (Lecturer in Rheumatology, Honorary Consultant Rheumatologist)

  5. Clinical Research Department, Imperial Chemical Industries PLC, Pharmaceuticals Division, Alderley Park, Macclesfield, UK

    A. Rushton MB ChB MRCP (Drug team leader) (Drug team leader)

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© 1986 J. M. H. Moll, H. A. Bird and A. Rushton

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Madhok, R., Capell, H.A. (1986). Evaluation of drug response. In: Moll, J.M.H., Bird, H.A., Rushton, A. (eds) Therapeutics in Rheumatology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2883-2_5

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  • DOI: https://doi.org/10.1007/978-1-4899-2883-2_5

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