Simple goitre (non-endemic, non-toxic goitre) and multinodular goitre
Simple goitre is one of the least simple thyroid disorders with particular regard to its pathogenesis. Henneman’s  clinical definition of simple goitre as ‘a benign, diffuse or multinodular enlargement of the thyroid of unknown etiology with normal hormone production occurring sporadically’ is difficult to improve. Studer and Ramelli  have defined the condition ‘as a slowly developing diffuse or nodular enlargement of the thyroid gland resulting from excessive replication of epithelial cells with subsequent generation of new follicles of widely differing structure and function’. By convention, goitres whose causes are known are not included under the term simple goitre. Therefore, Hashimoto’s thyroiditis, euthyroid Graves’ disease, iodine deficiency, and goit-rogen induced goitre are excluded.
KeywordsIodine Deficiency Multinodular Goitre Nodular Goitre Thyroid Status Thoracic Inlet
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