Simple goitre (non-endemic, non-toxic goitre) and multinodular goitre
Simple goitre is one of the least simple thyroid disorders with particular regard to its pathogenesis. Henneman’s  clinical definition of simple goitre as ‘a benign, diffuse or multinodular enlargement of the thyroid of unknown etiology with normal hormone production occurring sporadically’ is difficult to improve. Studer and Ramelli  have defined the condition ‘as a slowly developing diffuse or nodular enlargement of the thyroid gland resulting from excessive replication of epithelial cells with subsequent generation of new follicles of widely differing structure and function’. By convention, goitres whose causes are known are not included under the term simple goitre. Therefore, Hashimoto’s thyroiditis, euthyroid Graves’ disease, iodine deficiency, and goit-rogen induced goitre are excluded.
KeywordsCorticosteroid Iodine Shrinkage Barium Progesterone
Unable to display preview. Download preview PDF.
- 3.Studer, H. (1982) A fresh look at an old disease: euthyroid and hyperthyroid nodular goitre. J. Endocri. Invest, 5, 57–68.Google Scholar
- 8.Stanbury, J.B. and Wang, C-A. (1981) Nontoxic goiter, in Thyroid Today, (ed. J.H. Oppenheimer) 4, 1–5.Google Scholar
- 10.Drexhage, H.A., Doniach, D., Bottazzo, G.F. et al. (1982) Detection and clinical significance of antibodies stimulating or blocking thyroid growth in disorders of the thyroid gland, in Current Endocrine Concepts, (ed. E.D. Williams), Praeger Publishers, London pp. 37–55.Google Scholar
- 13.Sokal, J.E. (1960) The incidence of thyroid cancer and the problem of malignancy in nodular goiter, in Clinical Endocrinology, (ed. E.B. Astwood), Grune and Stratton, New York, p. 168.Google Scholar
- 14.Trotter, W.R. (1962) Diseases of the Thyroid, FA Davis Company, Philadelphia, pp. 133–43.Google Scholar
- 15.Burrow, G.N. (1989) Nontoxic goiter — diffuse and nodular, in Thyroid Function and Disease, (eds G.N. Burrow, J.H. Oppenheimer and R. Volpe), WB Saunders Co, Philadelphia, London, Toronto, Montreal, Sydney and Tokyo, pp. 141–51.Google Scholar
- 23.Glazer, G.M., Axel, L. and Moss, A.A. (1982) CT diagnosis of mediastinal thyroid. A.J.R., 138, 495–8.Google Scholar