Diminished D2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements
Oral movements in rats, repetitive jaw movements (RJM), can be induced in a dose dependent manner by a specific D1 agonist, SKF 38393, and decreased by D2 receptor stimulation with a specific D2 agonist, LY 141865. Irreversible D1 receptor inactivation by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline severely reduced oral responses induced by SKF 38393, whereas such blockade of D2 receptors greatly augmented the D1 mediated behavior. Further, we found that chronic prolonged D1 receptor blockade following administration of fluphenazine decanoate facilitated repetitive jaw movements.
KeywordsTardive Dyskinesia Neuroleptic Treatment Fluphenazine Decanoate Receptor Supersensitivity Oral Movement
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