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The Enzymes of Biological Membranes pp 283–310Cite as

Membrane-Bound Hormone Receptors

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Abstract

Receptors are those cellular structures with which biologically active hormones and drugs first interact. Physiologically these receptors perform two essential functions. The first is that of recognition of a particular biologically active chemical structure presumably by some complimentarity in the structure of the hormone or drug and the receptor itself. This recognition is effected by specific binding of the hormone or drug to the cellular receptor structures. The second function of these receptors is that of activation of biological processes. This may be effected through a stimulation of an enzyme activity, a change in the membrane conductance for a specific ion, etc. For certain hormones, e.g., the steroid hormones, the receptors appear to be cytoplasmic in location (Baulieu et al., 1971). For many other hormones and drugs, however, the receptor structures appear to be located within the plasma membranes of the responsive target cells. This chapter will be confined to the latter class of hormone receptors.

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Authors and Affiliations

  1. Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Robert J. Lefkowitz, Marc G. Caron, Lee Limbird, Chhabirani Mukherjee & Lewis T. Williams

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  1. Robert J. Lefkowitz
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  5. Lewis T. Williams
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  1. Department of Biochemistry, School of Medicine, Saint Louis University, St. Louis, Missouri, USA

    Anthony N. Martonosi

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© 1976 Springer Science+Business Media New York

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Lefkowitz, R.J., Caron, M.G., Limbird, L., Mukherjee, C., Williams, L.T. (1976). Membrane-Bound Hormone Receptors. In: Martonosi, A.N. (eds) The Enzymes of Biological Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2693-7_10

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  • DOI: https://doi.org/10.1007/978-1-4899-2693-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2695-1

  • Online ISBN: 978-1-4899-2693-7

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