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What is the Pathogenesis of Familial Gouty Nephropathy?

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 309A)

Abstract

Familial juvenile gouty nephropathy (FJGN; McCusick 16200) was first noted by Duncan and Dixon in 1960 (1). We first observed the condition in 1968–72 (2), and by 1990 18 papers describing 38 affected kindreds containing 130 affected individuals had been described (3), plus three new kindreds described more recently (4–7). We are also aware of a number of unpublished kindreds, from some of whom material has been available to us for study. The purpose of this communication is to summarise what information we have accumulated; to speculate from these data, published and unpublished, as to what the pathogenesis of FJGN may be; and to suggest further studies which may illuminate the problem in the future.

Keywords

Interstitial Nephritis Urate Crystal Crystal Deposition Disease Proximal Tubular Epithelium Urate Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  1. 1.Purine Research LaboratoryLondonUK
  2. 2.Renal Unit Guy’s Campus UMDSLondonUK

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