Abstract
The uricosuric substance benzbromarone initially was reported to be debrominated to bromobenzarone and benzarone (Yü 1976). Recently hydroxilation was shown to be the primary metabolic pathway (Walter-Sack et al 1987). In addition, in a few individuals pharmacokinetic studies showed evidence for a deficient benzbromarone elimination from plasma, characterized by a longer persistance of benzbromarone in the plasma (Walter-Sack et al 1988; Walter-Sack et al 1990a), which is likely to be a familial disorder (Zöllner et al 1990).
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References
Gresser U (1990) Therapie von Hyperurikämie und Gicht mit Urikosurika. Mediscript-Verlag München, ISBN 3-88320-202-9
Ittensohn A, de Vries JX (1989) A simplified method for a quantitative determination of benzbromarone in human plasma by HPLC. Eur J Clin Pharmacol 36 (Suppl): A228
Praetorius E, Poulson H (1963) Enzymatic determination of uric acid with detailed directions. Scand J clin Lab Invest 5: 273–279
Walter-Sack I, de Vries JX, Ittensohn A, Weber E (1987) Benzbromarone disposition following single dose application. Evidence for lack of debromination to benzarone. Klin Wochenschr 65 (Suppl X): 5
Walter-Sack I, de Vries JX, Ittensohn A, Kohlmeier M, Weber E (1988) Benzbromarone disposition and uricosuric action; evidence for hydroxilation instead of debromination to benzarone. Klin Wochenschr 66: 160–166
Walter-Sack I, Gresser U, Adjan M, Kamilli I, Ittensohn A, de Vries JX, Weber E, Zöllner N (1990a) Variation of benzbroma-rone elimination in man-a population study. Eur J Clin Pharmacol 39: 173–176
Walter-Sack I, de Vries JX, Ittensohn A, Weber E (1990b) Rapid and slow benzbromarone elimination phenotypes in man: benzbromarone and metabolite profiles. Eur J Clin Pharmacol 39: 577–581
Yü T-F (1976) Pharmacokinetic and clinical studies of a new uricosuric agent-benzbromarone. J Rheumatol 3: 305–312
Zöllner N (1963) Eine einfache Modifikation der enzymatischen Harnsäurebestimmung. Normalwerte in der deutschen Bevölkerung. Z klin Chem 1: 178–183
Zöllner N, Gresser U, Walter-Sack I (1990) Deficient benzbromarone elimination: a familial disorder? Klin Wochenschr 68: 101
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© 1991 Springer Science+Business Media New York
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Gresser, U., Empl, H., Kamilli, I., Zöllner, N. (1991). Pharmacokinetics of Benzbromarone: Evidence for a Biliary-Intestinal-Biliary Recirculation. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_33
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DOI: https://doi.org/10.1007/978-1-4899-2638-8_33
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