Synergistic Interaction of Methotrexate and 6-Mercaptopurine in Human Derived Malignant T-All and Calla+ Cell Lines
Methotrexate (MTX and 6-mercaptopurine (6MP) are antimetabolites which are commonly used in the treatment of acute lymphoblastic leukemia (ALL). Synergistic cytotoxic effects can be expected from combinations of MTX and 6MP, based on the biochemical pharmacology of both drugs.
KeywordsAcute Lymphoblastic Leukemia Methylene Tetrahydrofolate Thymidylate Synthetase Synergistic Cytotoxic Effect Purine Metabolite
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