Synergistic Interaction of Methotrexate and 6-Mercaptopurine in Human Derived Malignant T-All and Calla+ Cell Lines

  • Ronney A. De Abreu
  • Frank van Strien
  • Lambert H. J. Lambooy
  • J. P. M. Bökkerink
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 309A)


Methotrexate (MTX and 6-mercaptopurine (6MP) are antimetabolites which are commonly used in the treatment of acute lymphoblastic leukemia (ALL). Synergistic cytotoxic effects can be expected from combinations of MTX and 6MP, based on the biochemical pharmacology of both drugs.


Acute Lymphoblastic Leukemia Methylene Tetrahydrofolate Thymidylate Synthetase Synergistic Cytotoxic Effect Purine Metabolite 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Ronney A. De Abreu
    • 1
  • Frank van Strien
    • 1
  • Lambert H. J. Lambooy
    • 1
  • J. P. M. Bökkerink
    • 1
  1. 1.Centre for Pediatric Oncology SE Netherlands, Department of PediatricsUniversity Hospital NijmegenThe Netherlands

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