Skip to main content

6-Mercaptopurine Metabolism in Two Leukemic Cell Lines

  • Chapter
Purine and Pyrimidine Metabolism in Man VII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 309A))

Abstract

6-Mercaptopurine (6MP), an analogue of the purine base hypoxanthine, is commonly used in the maintenance therapy of acute lymphoblastic leukemia (ALL) in children1.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. L. Lennard, J.S. Lilleyman, Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblasic leukemia, J. Clin. Oncol. 7:1816 (1989).

    PubMed  CAS  Google Scholar 

  2. L. Lennard, D. Keen, J.S. Lilleyman, Oral 6-mercaptopurine in childhood leukemia: parent drug pharmacokinetics and active metabolite concentrations, Clin. Pharmacol. Ther. 40:287 (1986).

    Article  PubMed  CAS  Google Scholar 

  3. M. Uchida, T. Nakamura, H. Uchino, Conversion of 6-mercaptopurine to 6-thioguanylic acid in L1210 cells and human leukemia cells, Jpn.J. Cancer Res. (GANN) 76:124 (1985).

    CAS  Google Scholar 

  4. J.P.M. Bökkerink, F.J. Damen, T.W. Hulscher, M.A.H. Bakker, J. A van Baal, R.A. De Abreu, 6-mercaptopurine cytotoxicity and biochemical pharmacology in human malignant lymphoblasts of different lineages, submitted

    Google Scholar 

  5. J.A. Nelson, J.W. Carpenter, L.M. Rose, D.J. Adamson, Mechanisms of action of 6-thioguanine, 6-mercaptopurine and 8-azaguanine, Cancer Res. 35:2872 (1975).

    PubMed  CAS  Google Scholar 

  6. J. Maybaum, H.G. Mandel, Unilateral chromatid damage: a new basis for 6-thioguanine cytotoxicity, Cancer Res. 43:3852 (1983).

    PubMed  CAS  Google Scholar 

  7. N.T. Cristie, S. Drake, R.E. Meyn, J.A Nelson, 6-Thioguanine-induced DNA-damage as determinant of cytotoxicity in cultured hamster ovary cells, Cancer Res. 44:3665 (1984).

    Google Scholar 

  8. F.R. Collart, E. Huberman, Expression of IMP dehydrogenase in differentiating HL60 cells, Blood 75:570 (1990).

    PubMed  CAS  Google Scholar 

  9. L.L. Bennet, P.W. Allan, Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine, Cancer Res. 31:152 (1971).

    Google Scholar 

  10. C.N. Remy, Metabolism of thiopyrimidines and thiopurines; S-methylation with S-adenosyl methionine transmethylase and catabolism in mammalian tissue, J. Biol. Chem. 238:1078 (1963).

    PubMed  CAS  Google Scholar 

  11. A R.P. Paterson, D.M. Tidd, 6-thiopurines, in: “Antineoplastic and immunosuppressive agents II”, A.C. Sartorelli, ed, Plenum Berlin, Heidelberg, New York (1975).

    Google Scholar 

  12. R.A. De Abreu, J.M. van Baal, J.AJ.M. Bakkeren, C.H.M.M. de Bruyn, E.D.A.M. Schretlen, High performance liquid Chromatographic assay for identification and quantitation of nucleotides in lymphocytes and malignant lymphoblasts, J. Chromatogr. 227:45 (1982).

    PubMed  Google Scholar 

  13. J.P.M. Bökkerink, M.A.H. Bakker, T.W. Hulscher, R.A De Abreu, E.D.A M. Schretlen, Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages, Biochem. Pharmacol. 37:2321 (1988).

    Article  PubMed  Google Scholar 

  14. H.J. Lee, K. Pawlak, B.T. Nguyen, R.K. Robbins, W. Sadée, Biochemical differences among four inosinate dehydrogenase inhibitors, mycophenolic acid, ribavirin, tiazofurin, and selenazofurin, studied in mouse lymphoma cell culture, Cancer Res. 45:5512 (1985).

    PubMed  CAS  Google Scholar 

  15. S.M. Kharbanda, M.L. Sherman, D.W. Kufe, Effects of tiazofurin on guanine nucleotide binding regulatory proteins in HL60 cells, Blood 75:583 (1990).

    PubMed  CAS  Google Scholar 

  16. M.T. Rizzo, G.T. Tricot, R. Hoffman, H.N. Nayaram, G. Weber, J.G.N. Garcia, D. English, IMPDH inhibitors. Probes for investigation of the functions of guanine binding proteis in intact cells, Cell. Signal. 2:509 (1990).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Stet, E.H., De Abreu, R.A., Janssen, Y.P.G., Bökkerink, J.P.M., Trijbels, J.M.F. (1991). 6-Mercaptopurine Metabolism in Two Leukemic Cell Lines. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-2638-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2640-1

  • Online ISBN: 978-1-4899-2638-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics