Abstract
My story began with the discovery of sulfanilamide—the fourth useful chemotherapeutic agent the world had known, Morris Fishbein in the Boston Herald of December 31, 1939, described the three previous specific remedies as: “quinine for malaria, arsphenamine for syphilis and diphtheria antitoxin. Sulfanilamide entered this “hall of fame” by acting as a specific for a strain of the streptococcus germ.” It was important for its therapeutic effects but perhaps more important for the development of the antimetabolite theory.
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References
G.H. Hitchings, E.A. Falco, M.B. Sherwood, Science 102:251 (1945).
J.H. Burchenal, D.A. Karnofsky, E.M. Kingsley-Pillers, C.M. Southam, W.P.L. Meyers, G.C. Escher, L.F. Craver, H.W. Dargeon, C.P. Rhoads, Cancer 4:549 (1951).
G.B. Elion, G.H. Hitchings, H, VanderWerff, J. Biol. Chem. 192:505 (1951).
J.H. Burchenal, M.L. Murphy, R.R. Ellison, M.P. Sykes, C.T.C. Tan, L.A. Leone, D.A. Karnofsky, L.F. Craver, H.W. Dargeon, C.P. Rhoads, Blood 8:965 (1953).
G.H. Hitchings and G.B. Elion, Cancer Res. 45:2415 (1985).
R. Schwartz, J. Stack and W. Dameshek, Proc. Soc. Exp. Biol. Med. 99:164 (1958).
R.Y. Calne, Lancet I:417 (1960).
J.E. Murray, J.P. Merrill, J.H. Harrison, R.E. Wilson, G.J. Dammin, N. Engl. J. Med. 268:1315 (1963).
G.B. Elion, in Les Prix Nobel 1988, Norstedts Tryckeri, Stockholm, 1989, pp. 267-288; also publ. In Vitro Cellular and Developmental Biology 25:321 (1989).
R.W. Rundles, J.B. Wyngaarden, G.H. Hitchings, G.B. Elion, H.R. Silberman, Trans. Assoc. Am. Physioians 76:126 (1963).
J.J. Marr, R.L. Berens, D.J. Nelson, Science 201:1018 (1978).
D.J. Nelson, C.J.I. Bugge, G.B. Elion, R.L. Berens, J.G. Marr, J. Biol. Chem. 254:3959 (1979).
G.H. Hitchings, Cancer Res. 29:1895 (1969).
G.H. Hitchings in Les Prix Nobel 1988, Norstedts Tryckeri, Stockholm, 1989, pp. 296-313; also publ. In Vitro Cellular and Development Biololgy 25:303 (1989).
E.A. Falco, L.G. Goodwin, G.H. Hitchings, I.M. Rollo, P.B. Russell, Brit. J. Pharmacol. 6:185 (1951).
B. Roth, E.A. Falco, G.H. Hitchings, J. Med. Pharm. Chem. 5:1103 (1962).
S.R.M. Bushby, G.H. Hitchings, Brit. J. Pharmac. Chemother. 33:72 (1968).
J.J. Burchall, G.H. Hitchings, Molec. Pharmacol. 1:126 (1965).
G.H. Hitchings, J.J. Burchall, Adv. Enzymol. 27:417 (1965).
S.R.M. Bushby, in Trimethoprim-Sulfamethoxazole, Microbiological Pharmacological and Clinical Considerations, ed. by M. Finland and E.H. Kass, pp. 10-30 (1973).
G.B. Elion, P.A. Furman, J.A. Fyfe, P. de Miranda, L. Beauchamp, H.J. Schaeffer, Proc. Natl. Acad. Sci. USA 74:5716 (1977).
H.J. Schaeffer, L. Beauchamp, P. de Miranda, G.B. Elion, D.J. Bauer, P. Collins, Nature 272:583 (1978).
G.B. Elion, Cancer Res. 45:2943 (1985).
P.A. Furman, J.A. Fyfe, M.H. St. Clair, K. Weinhold, J.L. Rideout, G.A. Freeman, S.N. Lehrman, D.P. Bolognesi, S. Broder, H. Mitsuya, D.W. Barry, Proc. Natl. Acad. Sci. USA 83:8333 (1986).
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Hitchings, G.H. (1991). Biochemical Approach to New Medications. In: Harkness, R.A., Elion, G.B., Zöllner, N. (eds) Purine and Pyrimidine Metabolism in Man VII. Advances in Experimental Medicine and Biology, vol 309A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2638-8_1
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