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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 289))

Abstract

Worldwide, locally prevailing nutritional traditions account for the occurrence of specific types of cancer. In the Orient, the custom of eating salted, pickled or smoked food parallels the risk of stomach cancer and hypertension-stroke. The underlying mechanisms and relevant carcinogens are partially known. In the Western world, the usual highfat, low-fiber food is related to risk of cancer of the colon, pancreas, breast, prostate, ovary, and endometrium. The fat component translates to specific promoting mechanisms and fibers reduce risk of colon cancer through dilution of promoters. The associated genotoxic carcinogens may be the heterocyclic amines formed during cooking of meat. Methods have been developed to inhibit their formation. In all situations, a higher intake of vegetables and fruits has led to a lower risk for diverse types of cancer, through varied mechanisms. Based on current knowledge, more wholesome dietary traditions for chronic disease prevention in most countries can be developed.

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References

  • American Health Foundation. (1987). Workshop on New Developments on Dietary Fat and Fiber in Carcinogenesis (optimal types and amounts of fat or fiber). Prev. Med. 16, 449–595.

    Article  Google Scholar 

  • Bartsch, H., Ohshima, H., Shuker, D. E. G., Pignatelli, B., and Calméis, S. (1990). Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology. Mutation Res. 238, 255–267.

    Article  CAS  Google Scholar 

  • Berenblum, I. (1985). Challenging problems in cocarcinogenesis. Cancer Res. 45, 1917–1921.

    CAS  Google Scholar 

  • Bird, R. P., Schneider, R., Stamp, D., and Bruce, W. R. (1986). Effect of dietary calcium and cholic acid on the proliferatile indices of murine colonic epithelium. Carcinogenesis, 7, 1657–1661.

    Article  CAS  Google Scholar 

  • Breslow, L. (1990). The future of public health: Prospects in the United States for the 1990’s. Ann. Rev. Public Health, 11, 1–28.

    Article  CAS  Google Scholar 

  • Bridges, B. A., Butterworth, B. E., and Weinstein, I. B. (eds.). (1982). Banbury Report 13. Cold Spring Harbor Laboratory. Indicators of genotoxic exposure.

    Google Scholar 

  • Clayson, D. B., Nera, E. A., and Lock, E. (1989). The potential for the use of cell proliferation studies in carcinogen risk assessment. Regul.Pharmacol. Toxicol. 9, 284–295.

    Article  CAS  Google Scholar 

  • Cohen, L. A., Choi, K., Weisburger, J. H., and Rose, D. P. (1986). Effect of varying proportions of dietary fat on the development of N-nitrosomethylurea-induced rat mammary tumors. Anticancer Res. 6, 215–218.

    CAS  Google Scholar 

  • Committee on Diet and Health, Food and Nutrition Board. (1989). Implications for Reducing Chronic Disease Risk. National Academy Press, Washington, D. C.

    Google Scholar 

  • Conney, A. H. (1986). Induction of microsomal cytochrome P-450 enoymes: The first Bernard B. Brodie lecture at Pennsylvania State University. Life Sci. 39, 2493–2518.

    Article  CAS  Google Scholar 

  • Engle, A., Herber, J. R., and Reddy, B. S. (1990). Relationship between food consumption and dietary intake among healthy volunteers and implications for meeting dietary goals. J. Amer. Dietetic Assoc. 90, 47–48.

    Google Scholar 

  • Finot, P. A., Aeschbacher, H. U., Hurrell, R. F., and Liardon, R. (eds.). (1990). The Maillard Reaction in Food Processing, Human Nutrition, and Physiology. Birkhauser, Basel, Switzerland.

    Google Scholar 

  • Garro, A. J., and Lieber, C. S. (1990). Alcohol and cancer. Annu. Rev. Pharmacol. Toxicol. 30, 219–249.

    Article  CAS  Google Scholar 

  • Greenwald, P., Nixon, D. W., Malone, W. F., Kelloff, G. J., Stern, H. R., and Witkin, K. M. (1990). Concepts in cancer chemoprevention. Cancer Res. 65, 1483–1490.

    CAS  Google Scholar 

  • Hartman, P. E., and Shankel, D. M. (1990). Antimutagens and anticarcinogens: A survey of putative interceptor molecules. Env. Mol. Mutagen. 15, 145–182.

    Article  CAS  Google Scholar 

  • Hatch, F. T., Knize, M. G., Healy, S. K., Slezak, T., and Felton, J. S. (1988). Cooked-food mutagen reference list and index. Env. Mol. Mutagen. 12 (Supplement 14), 1–85.

    CAS  Google Scholar 

  • Hayashi, Y., Nagao, M., Sugimura, T., Takayama, S., Tomatis, L., Wattenberg, L. W., and Wogan, G. N. (eds.). (1986). Diet and Nutrition and Cancer. Japan Scientific Societies Press and VNU Science Press BV, Tokyo and Utrecht, 3–345.

    Google Scholar 

  • Hossain, M. Z., Wilkens, L. R., Mehta, R. P., Loewenstein, W., and Bertram, J. S. (1989). Enhancement of gap junctional communication by retinoid correlates with their ability to inhibit neoplastic transformation. Carcinogenesis, 10, 1743–1748.

    Article  CAS  Google Scholar 

  • Howson, C. P., Hiyama, T., and Wynder, E. L. (1986). The decline in gastric cancer: Epidemiology of an unplanned triumph. Epidemiol. Rev. 8, 1–27.

    CAS  Google Scholar 

  • Joossens, J. V., Hill, M. F., and Geboers, J. (1985). Diet and Human Carcinogenesis. Excerpta Medica, Amsterdam, Holland.

    Google Scholar 

  • Kumar, R., Sukumar, S., and Barbacid, M. (1990). Activation of ras oncogenes preceding the onset of neoplasia. Science 248, 1101–1104.

    Article  CAS  Google Scholar 

  • LaVeccia, C., Harris, R. E., and Wynder, E. L. (1988). Comparative epidemiology of cancer between the United States and Italy. Cancer Res. 48, 7285–7293.

    Google Scholar 

  • McGinnis, J. M. (1988–89). National priorities in disease prevention. Issues Science Technol. 5, 46–92.

    Google Scholar 

  • Meyskens, F. L. (1989). Proceedings of the Third International Conference on the Prevention of Human Cancer: Chemoprevention. Prev. Med. 18, 551–757.

    Article  Google Scholar 

  • Michnovich, J. J., and Bradlow, H. L. (1990). Induction of estradiol metabolism by dietary indole-3-carbinol in humans. J. Natl. Cancer Inst. 82, 947–949.

    Article  Google Scholar 

  • Newmark, H. L., Lipkin, M., and Maheshwari, N. (1990). Colonic hyperplasia and hyperproliferation induced by a nutritional stress diet with four components of Western-style diet. J. Natl. Cancer Inst. 82, 491–496.

    Article  CAS  Google Scholar 

  • Pariza, M. W. (1988). Dietary fat and cancer risk: Evidence and research needs. Annu. Rev. Nutr. 8, 167–183.

    Article  CAS  Google Scholar 

  • Pariza, M. W., Ha, Y. L., Benjamin, H., Sword, J. T., Gruter, A., Chin, S. F., Storkson, J., Faith, N., and Albright, K. (1991). Foramtion and action of anticarcinogenic fatty acids. This volume.

    Google Scholar 

  • Prentice, R. L., Kakar, F., Hursting, S., Sheppard, L., Klein, R., and Kushi, L.H. (1988). Aspects of the rationale for the Women’s Health Trial. J. Natl. Cancer Inst. 80, 802–814.

    Article  CAS  Google Scholar 

  • Reddy, B., Engle, A., Katsifis, S., Simi, B., Bartram, H-P., Perrino, P., and Mahan, C. (1989). Biochemical epidemiology of colon cancer: Effect of types of dietary fiber on fecal mutagens, acid, and neutral sterols in healthy subjects. Cancer Res. 49, 4629–4635.

    CAS  Google Scholar 

  • Rose, D. P. (1990). Dietary fiber and breast cancer. Nutr. Cancer, 13, 1–8.

    Article  CAS  Google Scholar 

  • Schapira, D. V., Kumar, N. B., Lyman, G. H., and McMillan, S. C. (1990). The value of current nutrition information. Prev. Med. 19, 45–53.

    Article  CAS  Google Scholar 

  • Simopoulos, A. P. (1987). Diet and health: Scientific concepts and principles. Am. J. Clin. Nutr. 45, 1027–1414.

    Google Scholar 

  • Sinkeldam, E. J., Kuper, C. F., Bosland, M. C., Hollanders, V. M. H., and Vedder, D. M. (1990). Interactive effects of dietary wheat bran and lard on N-methyl-N’-nitro-N-nitrosoguanidine-induced colon carcinogenesis in rats. Cancer Res. 50, 1092–1096.

    CAS  Google Scholar 

  • Tajima, K., Hirose, K., Nakagawa, N., Juroshishi, T., and Tominaga, S. (1985). Urban-rural difference in the trend of colo-rectal mortality with special reference to the subsites of colon cancer in Japan. Gann, 76, 717–728.

    CAS  Google Scholar 

  • Trowell, H., Burkitt, D., and Heaton, K. (eds.). (1985). Dietary Fibre, Fibre-Depleted Foods and Disease. Academic Press, London, England.

    Google Scholar 

  • Van’t Veer, P., Kolb, C., Verhoef, P., Kok, F. J., Schouten, E. J., Hermus, R. J. J., and Stermans, F. (1990). Dietary fiber, betacarotene and breast cancer: Results from a case-control study. Int. J. Cancer, 45, 825–828.

    Article  Google Scholar 

  • Wakabayashi, K., Nagao, M., and Sugimura, T. (1989). Mutagens and carcinogens produced by the reaction of environmental aromatic compounds with nitrite. Cancer Surveys, 8, 385.

    CAS  Google Scholar 

  • Weinberg, R. A. (1989). Oncogens, antioncogens, and the molecular bases of multistep carcinogenesis. Cancer Res. 9, 3713–3721.

    Google Scholar 

  • Weisburger, J. H. (1990). On the mechanisms of carcinogenesis and statistical data management in tobacco smoking cessation. Epidemiology, 1, 314–317.

    Article  CAS  Google Scholar 

  • Weisburger, J. H. (1991). Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants and carotenoids. Am. J. Clin. Nutr. 53, 226s–237s.

    CAS  Google Scholar 

  • Williams, G. M. (1989). Methods for evaluating chemical genotoxicity. Annu. Rev. Pharmacol. Toxicol. 29, 189–211.

    Article  CAS  Google Scholar 

  • Williams, G. M., and Weisburger, J. H. (1991). Chemical carcinogens, In Casarett and Doull’s Toxicology, the Basic Science of Poisons, 4th ed., J. Doull, C. D. Klaassen, and M. O. Amdur (eds.). McMillan, New York.

    Google Scholar 

  • Wynder, E. L., and Hiyama, T. (1987). Comparative epidemiology of cancer in the united States and Japan: preventive implications. Gann Monogr. Cancer Res. 33, 181–191.

    Google Scholar 

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© 1991 Springer Science+Business Media New York

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Weisburger, J.H. (1991). Carcinogens in Our Food and Cancer Prevention. In: Friedman, M. (eds) Nutritional and Toxicological Consequences of Food Processing. Advances in Experimental Medicine and Biology, vol 289. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2626-5_12

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  • DOI: https://doi.org/10.1007/978-1-4899-2626-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2628-9

  • Online ISBN: 978-1-4899-2626-5

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