Abstract
Experimental studies of single subjects have been an important part of psychological research for some time.1−3 The methodology is known as’ single case’ or’ single subject’ research, N = 1, or, as we shall call it, N of 1 trials. We have previously described how N of 1 randomized clinical trials (RCTs) may be used in medical practice to determine the optimum treatment of an individual patient and initiated an “N of 1 service” designed to assist clinicians who wish to conduct such a trial.4 More recently, we have provided detailed guidelines for clinicians to conduct their own N of 1 RCTs.5
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References
T.R. Kratchwill, ed, “Single subject research: strategies forevaluating change,” Academic Press, Orlando, Fla (1978).
D.H. Barlow, Hersen M., “Single case experimental designs: strategies for studying behavior change,” Pergamon Press 2nd ed, New York (1984).
A.E. Kazdin, “Single-case research designs: methods for clinical and applied settings,” Oxford University Press, New York (1982).
G.H. Guyatt, D. Sackett, D.W. Taylor, J. Chong, R. Roberts, and S. Pugsley, Determining Optimal Therapy-Randomized Trials in Individual Patients, N Engl J Med. 314:889–892 (1986).
G.H. Guyatt, D.L. Sackett, J.D. Adachi, and et. al., A Clinician’s guide for conducting randomized trials in individual patients, Can Med Ass J. 139:497–503 (1988).
S. Clark, S.M. Campbell, M.E. Forehand, and et. al, Clinical characteristics of fibrositis, Arthritis Rheum. 28:132–137 (1985).
S. Carette, G.A. McCain, D.A. Bell, and A.G. Fam, Evaluation of amitriptyline in primary fibrositis, Arthritis Rheum. 29:655–659 (1986).
O. Kempthorne, “The design and analysis of experiments,” John Wiley and Sons Incorporated, London, (1967).
B.E. Huitema, Autocorrelation in applied behavior analysis: a myth, Behav Assessment. 7:107–118 (1985).
R.S. Roberts, R. Jaeschke, J. Keller, and G.H. Guyatt, Design and analysis of N of 1 randomized trials: the options, Submitted for publication.
E.S. Edgington, Statistics and single case analysis, Prog Behav Modif. 16:83–119 (1984).
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© 1992 Springer Science+Business Media New York
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Guyatt, G.H. (1992). N of 1 Randomized Trials for Investigating New Drugs. In: Strom, B.L., Velo, G. (eds) Drug Epidemiology and Post-Marketing Surveillance. NATO ASI Series, vol 224. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2587-9_16
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DOI: https://doi.org/10.1007/978-1-4899-2587-9_16
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