Plants as Sources of Medicinally and Pharmaceutically Important Compounds

  • A. Douglas Kinghorn

Abstract

Mankind has profitably used extracts of plants for the treatment of human diseases for centuries. The beginning of the 19th century heralded an era in which the active secondary-metabolite principles of medicinal plants began to be purified, with such pure constituents then introduced into therapy, as evidenced in turn by morphine, quinine, atropine, papaverine, cocaine, and pilocarpine. Important plant-derived drugs have continued to be incorporated into the physician’s armamentarium in the 20th century, such as digitoxin, digoxin, ergometrine, ergotamine, reserpine, tubocurarine, vinblastine, and vincristine (Baerheim Svendsen and Scheffer, 1982; Tyler et al, 1988). The current importance and/or the potential of plants as sources of drug substances per se, as lead compounds for synthetic modification, and as excipients in pharmaceutical formulations has been addressed by others in recent years (Baerheim Svendsen and Scheffer, 1982; Balandrin and Klocke, 1988; Balandrin et al, 1985; Farnsworth, 1984; Galeffi and Marini-Bettolo, 1988; Hosier and Mikita, 1987; Phillipson and Anderson, 1987, 1989; Steiner, 1986; Tyler et al., 1988).

Keywords

Cocaine Malaria Glycoside Digoxin Bark 

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • A. Douglas Kinghorn
    • 1
  1. 1.Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy College of PharmacyUniversity of Illinois at ChicagoChicagoUSA

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