Abstract
Collision-induced dissociation (CID) [also called collision-activated dissociation (CAD), tandem mass spectrometry, or MS/MS] of ions in a mass spectrometer plays an increasingly significant role in ion structure determination and analysis of complex mixtures.(1,2) Improvement in MS/MS techniques has been a significant driving force in mass spectrometric instrumental development. The CID has attained even greater importance with the advent of fast atom bombardment,(3) laser desorption,(4) and electrospray(5) techniques for generating ions from large, nonvolatile molecules. These techniques usually produce (quasi-and multi-charged) molecular ions with very little fragmentation. Collisional activation of these “molecular” ions and subsequent dissociation to various fragment ions provides structural information about these “molecular ion moities” required for identification and characterization. A few closely related methods, such as angle-resolved(6) and energy-resolved(7) mass spectrometry, surface-induced,(8) and photon-inducedt(9) dissociations have also been developed and succesfully applied in the past decade. Although it is a well-established method with many important applications to chemical analysis, CID remains an active research area in mass spectrometry with many nuances being actively explored.
Keywords
- Collision Energy
- Potential Energy Surface
- Kinetic Energy Release
- Contour Diagram
- Relative Velocity Vector
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Shukla, A.K., Futrell, J.H. (1994). Fundamental Studies of Collision-Induced Dissociation of Ions. In: Russell, D.H. (eds) Experimental Mass Spectrometry. Topics in Mass Spectrometry, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2569-5_3
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