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Molecular Biology of Leukemias and Lymphomas

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Molecular Basis of Human Cancer

Part of the book series: NATO ASI Series ((NSSA,volume 209))

Abstract

Since the discovery of the Philadelphia chromosome as a consistent marker for the malignant cells in chronic myelogenous leukemias (1), non random chromosomal changes have been found in several neoplastic diseases of the hematopoietic system (2, 3). Many of these somatic genetic changes involve reciprocal chromosomal traslocations (3), and some have now been shown to occur at or near a proto-oncogene locus. The presence of these chromosomal aberrations have suggested fruitful approaches to the molecular understanding of these tumors. We, therefore, have taken advantage of lymphoid-specific chromosome abnormalities to analyze the mechanisms of oncogenesis in B and T cells on the molecular level.

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Authors and Affiliations

  1. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, Pennsylvania, 19140, USA

    Carlo M. Croce & Charlotte E. Gauwerky

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  1. Carlo M. Croce
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  2. Charlotte E. Gauwerky
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  1. University of Genoa, Genoa, Italy

    Claudio Nicolini

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Croce, C.M., Gauwerky, C.E. (1991). Molecular Biology of Leukemias and Lymphomas. In: Nicolini, C. (eds) Molecular Basis of Human Cancer. NATO ASI Series, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2563-3_7

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  • DOI: https://doi.org/10.1007/978-1-4899-2563-3_7

  • Publisher Name: Springer, Boston, MA

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