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Hormonal Regulation of the Hepatic 2-Oxoglutarate Dehydrogenase Complex

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Integration of Mitochondrial Function

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Abstract

It is fairly well established that three mammalian mitochondrial dehydrogenases, the NAD+-isocitrate dehydrogenase, the pyruvate dehydrogenase complex, and 2-oxoglutarate dehydrogenase complex are activated by Ca2+ ions in the micromolar range (Denton and McCormack, 1980, 1981; Hansford, 1985). While Ca2+ ions increase the amount of the pyruvate dehydrogenase in the active form due to activation of pyruvate dehydrogenase phosphatase, activation of the 2-oxoglutarate dehydrogenase and NAD+-isocitrate dehydrogenase is the result of decreased Km for their substrates, 2-oxoglutarate and isocitrate, respectively (Denton et al, 1978; McCormack and Denton, 1979).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Univ. of Tennessee, Memphis, The Health Science Center, 874 Union Avenue, Memphis, TN, 38163, USA

    Tarun B. Patel & Hani M. Rashed

Authors
  1. Tarun B. Patel
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  2. Hani M. Rashed
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Editor information

Editors and Affiliations

  1. Laboratories for Cell Biology, Department of Cell Biology & Anatomy, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599-7090, USA

    John J. Lemasters  & Charles R. Hackenbrock  & 

  2. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599, USA

    Ronald G. Thurman

  3. Laboratory of Molecular Biology NIDDK, NIH, Building 2, Room 319, Bethesda, MD, 20892, USA

    Hans V. Westerhoff

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© 1988 Springer Science+Business Media New York

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Patel, T.B., Rashed, H.M. (1988). Hormonal Regulation of the Hepatic 2-Oxoglutarate Dehydrogenase Complex. In: Lemasters, J.J., Hackenbrock, C.R., Thurman, R.G., Westerhoff, H.V. (eds) Integration of Mitochondrial Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2551-0_51

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  • DOI: https://doi.org/10.1007/978-1-4899-2551-0_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2553-4

  • Online ISBN: 978-1-4899-2551-0

  • eBook Packages: Springer Book Archive

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