Glucagon Stimulation of Mitochondrial Metabolism
It has been known for a number of years that if liver mitochondria are isolated either from rats treated a few minutes with glucagon or from hepatocytes treated briefly in vitro with the hormone, the mitochondria exhibit remarkable changes in a number of functions. Among these are increases in the rates of state 3 and uncoupled respiration, the carboxylation of pyruvate, the formation of citrulline, and the activity of the uncoupler-dependent ATPase. In addition, the mitochondria contain an increased quantity of adenine nucleotides. Except for this last phenomenon, the increase in mitochondrial nucleotides, the physiological significance of these events is not known, nor is the mechanism by which glucagon and other hormones produce these changes.
KeywordsHydrolysis Magnesium EDTA Bromide Respiration
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- Kraayenhof, R. and VanDam, K., 1969, Biochim. Biophys. Acta, 233:580–590.Google Scholar