Lithium Ion is a Competitive Inhibitor of the Na+ Selective Na+/H+ Antiporter from Mitochondria
The existence of an inner membrane Na+/H+ antiporter in mitochondria was predicted by Peter Mitchell (1961) and later demonstrated experimentally by Mitchell and Moyle (1967; 1969). These and subsequent studies by Douglas and Cockrell (1974) and Brierley (1976) led to the conclusions that mitochondria possess one Na+/H+ antiporter and that this porter also catalyzes K+/H+ exchange at a much lower rate. Indeed K+/H+ exchange was so low that some workers (Rosen and Futai, 1980) concluded that mitochondria do not possess such activity.
KeywordsFiltration Lithium Cytosol HEPES Mannitol
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