Abstract
Humans living in a highly industrialized society are increasingly exposed to many environmental chemical pollutants deliberately or accidentally introduced into the biosphere. Approximately 65,000 chemicals are in use today. This includes about 1500 active ingredients of pesticides, drugs, and food additives. Although many of these chemicals represent little danger to public health, the scientific community has become increasingly concerned about the adverse health effects of widespread chemical pollution. This awareness has stimulated much research into the exposure, metabolism, and toxicity of chemical pollutants. This chapter discusses one aspect of the bodily defense against pollutant exposure—detoxication mechanisms, with particular emphasis on their relationship to nutrition. The discussion focuses on several key environmental chemicals (Table 9–1) that represent a problem because of their ubiquitous environmental disposition, their potential toxicity, or their long persistence within the body.
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References
Albro PW, Moore B: Identification of the metabolites of simple phthalate diesters in rat urine. J Chroma-togr 94:209, 1974.
Alvares AP, Kappas A, Anderson KE, et al: Nutritional factors regulating drug biotransformations in man. In: Advances in Pharmacology and Therapeutics, Vol 8, pp 43–51, Olive G (ed.), Pergamon Press, New York, 1979.
Alvares AP, Pantuck EJ, Anderson KE, et al: Regulation of drug metabolism in man by environmental factors. Drug Metab Rev 9:185, 1979.
Anderson HA, Wolff MS, Lilis R, et al: Symptoms and clinical abnormalities following ingestion of polybrominated-biphenyl contaminated food products. Ann NY Acad Sci 320:684, 1979.
Anderson KE, Conney AH, Kappas A: Nutritional influences on chemical biotransformations in humans. Nutr Rev 40:161, 1982.
Angerer J: Occupational chronic exposure to organic solvents. Metabolism of toluene in man. Int Arch Occup Environ Health 43:63, 1979.
Bach PH, Bonner FW, Bridge JW, et al (eds.): Nephrotoxicity: Assessment and Pathogenesis. John Wiley & Sons, New York, 1982.
Baselt RC, Cravey RH: Disposition of Toxic Drugs and Chemicals in Man. Year Book Medical Publishers, Chicago, 1989.
Bickel MH, Muehlebach S: Pharmacokinetics and ecodisposition of polyhalogenated hydrocarbons: Aspects and concepts. Drug Metab Rev 11:149, 1980.
Blumberg WE: Enzymic modification of environmental intoxicants: The role of cytochrome P450. Q Rev Biophys 11:481, 1978.
Boyd EM, Taylor FI: The acute oral toxicity of chlor-dane in albino rats fed for 28 days from weaning on a protein-deficient diet. Ind Med Surg 38:434, 1969.
Bridges JW, Back PH, Bonner FW, et al: The effects of nutritional factors on renal response to toxins. In: Nephrotoxicity: Assessment and Pathogenesis, p 182, Bach PH, Bonner FW, Bridges JW, et al. (eds.), John Wiley & Sons, New York, 1982.
Calabrese EJ: Nutrition and Environmental Health. The Influence of Nutritional Status in Pollutant Toxicity and Carcinogencity, Vol 1, The Vitamins, John Wiley & Sons, New York, 1980.
Calabrese EJ: Nutrition and Environmental Health. The Influence of Nutritional Status in Pollutant Toxicity and Carcinogencity, Vol 2, Minerals and Macro-nutrients, John Wiley & Sons, New York, 1981.
Campbell TC: Nutrition and drug metabolising enzymes. Clin Pharmacol Ther 22:699, 1977.
Campbell TC: Influence of nutrition on metabolism of carcinogens. In: Advances in Nutrition Research, Vol 2, p 29, Draper HH (ed.), Plenum Press, New York, 1979.
Campbell TC, Hayes JR: Role of nutrition in the drug-metabolising enzyme system. Pharmacol Rev 26:171, 1974.
Campbell TC, Hayes JR: The effect of quantity and quality of dietary protein on drug metabolism. Fed Proc 35:2470, 1976.
Campbell TC, Hayes JR, Merrill AH Jr, et al: The influence of dietary factors on drug metabolism in animals. Drug Metab Rev 9:173, 1979.
Chambers JE, Irevathan CA: Effect of Mirex, de-chlorinated Mirex derivatives and chlordecone on microsomal mixed function oxidase activity and other hepatic parameters. Toxicol Lett 16:109, 1983.
Clayson DB: Nutrition and experimental carcinogenesis: A review. Cancer Res 35:3292, 1975.
Cohen GM, Mannering GJ: Involvement of a hydrophobic site in the inhibition of the microsomal para-hydroxylation of aniline by alcohols. Mol Pharmacol 8:383, 1973.
Committee on Diet, Nutrition, and Cancer, National Research Council: Diet Nutrition and Cancer, National Academy Press, Washington, 1982.
Conference on Nutrition on the Causation of Cancer: Cancer Res 35:3301–3303, 1975.
Connelly JC, Bridges JW: The distribution and role of cytochrome P450 in extrahepatic organs. In: Progress in Drug Metabolism, Vol 5, p 1, Bridges JW, Chas-seaud LF (eds.), John Wiley & Sons, New York, 1980.
Conney AH, Burns JJ: Metabolic interactions among environmental chemicals and drugs. Science 178:576, 1972.
Cooper DY, Levin S, Narasimhulu S, et al: Photochemical action spectrum of the terminal oxidase of mixed function oxidase systems. Science 147:400, 1965.
Cooper DY, Schleyer H, Levin SS, et al: A re-evaluation of the role of cytochrome P450 as the terminal oxidase in hepatic microsomal mixed function oxidase-catalysed reactions. Drug Metab Rev 10:153, 1979.
Costa AK, Ivanetich KM: Vinylidene chloride: Its metabolism by hepatic microsomal cytochrome P450 in vitro. Biochem Pharmacol 21:2083, 1982.
Costa AK, Ivanetich KM: The 1,2-dichloroethylenes: Their metabolism by hepatic cytochrome P450 in vitro. Biochem Pharmacol 31:2093, 1982.
Coulston F, Pocchiari F (eds.): Accidental Exposure to Dioxins. Human Health Aspects. Ecotoxicity and Environmental Quality Series, Academic Press, Orlando, 1983.
Dahl AR, Hodgson E: The interaction of aliphatic analogues of methylenedioxyphenyl compounds with cytochromes P450 and P420. Chem Biol Interact 27:163, 1979.
Dannam GA, Guengerich FR Kaminsky LS, et al: Regulation of cytochrome P450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. J Biol Chem 258:1282, 1983.
Dauterman WC: The role of hydrolases in insecticide metabolism and the toxicological significance of the metabolites. J Toxicol Clin Toxicol 19:623, 1983.
Derr SK: In vivo metabolism of exogenous progesterone by polychlorinated biphenyl-treated female rats. Bull Environ Contam Toxicol 19:729, 1978.
Dickerson JWT: The inter-relationship of nutrition and drugs. In: Nutrition in the Clinical Management of Disease, p 308, Dickerson JWT, Lee HA (eds.), Edward Arnold, London, 1978.
Dingell JV, Heimberg M: The effects of halogenated hydrocarbons on hepatic drug metabolism. Biochem Pharmacol 17:1269, 1964.
Dorough HW: Toxicological significance of pesticide conjugates. J Toxicol Clin Toxicol 19:637, 1983.
Dossing M: Changes in hepatic microsomal enzyme function in workers exposed to mixtures of chemicals. Clin Pharmacol Ther 32:340, 1982.
Drummond GS, Kappas A: The cytochrome P450-depleted animal; an experimental model for in vivo studies in chemical biology. Proc Natl Acad Sci USA 79:2384, 1982.
Environmental Chemicals and Nutrition. Relationship to Metabolism, Action and Toxicology of Drugs: Clin Pharmacol Ther 22(5, part 2):623–824, 1977.
Estabrook RW, Lindenlaub E, Oesch R, et al: Toxicological and Immunological Aspects of Drug Metabolism and Environmental Chemicals, Symposia Medica Hoechst 22, FK Schattauer Verlag, Stuttgart, 1988.
Fishbein L: Industrial mutagens and carcinogens. I. Halogenated aliphatic derivatives. Mutat Res 32:267, 1976.
Franklin MR: Inhibition of mixed function oxidations by substrates forming reduced cytochrome P450 metabolic-intermediate complexes. Pharmacol Ther A 2:227, 1979.
Fujji K, Jaffe H, Bishop Y, et al: Structure-activity relationships for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice. Toxicol App Pharmacol 16:482, 1970.
Gelboin HV: Benzo(a)pyrene metabolism, activation and carcinogenesis. Role and regulation of mixed function oxidases and related enzymes. Physiol Rev 60:1107, 1980.
Gibson GG: Comparative aspects of the mammalian cytochrome P450 IV gene family. Xenobiotica 19:1123, 1989.
Gibson JR, Ivie GW, Dorough HW: Fate of Mirex and its major photodecomposition product in rat. J Agric Food Chem 20:1246, 1972.
Goldstein JA, Hickman P, Bergman H, et al: Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P450 or cytochrome P448. Chem Biol Interact 17:69, 1977.
Goldstein JA, Linko PC, Levy LA, et al: A comparison of a commercial polybrominated biphenyl mixture 2,4,5,2’,4′,5′-hexabromobiphenyl and 2,3,6,7-tetrabromonaphthalene as inducers of liver microsomal drug metabolising enzymes. Biochem Pharmacol 28:2947, 1979.
Gregus Z, Watkins JB, Thompson TN, et al: Resistance of some phase II biotransformation pathways to hepatotoxins. J Pharmacol Exp Ther 222:471, 1982.
Guengerich FP: Isolation and purification of cytochrome P450 and the existence of multiple forms. Pharmacol Ther 6:99, 1979.
Guengerich FP: Effects of nutritive factors on metabolic processes involving bioactivation and detoxica-tion of chemicals. Annu Rev Nutr 4:207, 1984.
Guengerich FP, Mason RS, Scott WT, et al: Roles of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl bromide and vinyl chloride in irreversible binding to protein and DNA. Cancer Res 41:4391, 1981.
Guenther TM, Oesch F: Metabolic activation and inactivation of chemical mutagens and carcinogens. In: Drug Metabolism and Distribution, p 30, Lamble JN (ed.), Elsevier-North Holland, Amsterdam, 1983.
Gustafsson JA, Ingleman-Sundberg M: Changes in steroid hormone metabolism in rat liver microsomes following administration of 2,3,7,8-tetrachlorodi-benzo-p-dioxin (TCDD). Biochem Pharmacol 28:497, 1979.
Hammond EC, Selikoff IJ, Lawther PL, et al: Inhalation of benzo(a)pyrene and cancer in man. Ann NY Acad Sci 271:116, 1977.
Hanzlik RP: Reactivity and toxicity among haloge-nated methanes and related compounds. A physi-cochemical correlate with predictive value. Biochem Pharmacol 30:3027, 1981.
Harvey RG: Polycyclic hydrocarbons and cancer. Am Sci 70:386, 1982.
Hayatsu H, Arimoto S, Negishi T: Dietary inhibitors of mutagenesis and carcinogenesis. Mutat Res 202: 429, 1988.
Hopkins GJ, West CE: Possible roles of dietary fats in carcinogenesis. Life Sci 19:1103, 1976.
Hunter AL, Neal RA: Inhibition of hepatic mixed function oxidase activity in vitro and in vivo by various thiono-sulphur-containing compounds. Biochem Pharmacol 24:2199, 1975.
Hunter CG: Aromatic solvents. Ann Occup Hyg 9: 193, 1966.
Hutzinger O, Nash DM, Safe S, et al: Polychlorinated biphenyls: Metabolic behaviour of pure isomers in pigeons, rats and brook trout. Science 178:312, 1972.
Ideo G, Bellati G, Bellobuono A, et al: Increased urinary D-glucaric acid excretion by children living in an area polluted with tetrachlorodibenzoparadioxin (TCDD). Clin Chim Acta 120:273, 1982.
Infante PF, Wagoner JF, Rinsky RA, et al: Leukemia in benzene workers. Lancet 2:76, 1977.
Ionannides C, Parke DV: The cytochromes P-448—a unique family of enzymes involved in chemical toxicity and carcinogenesis, 36:4197, 1987.
Ionannides C, Parke DV: The cytochrome P4501 gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals. Drug Metab Rev 22:1, 1990.
Jaffe H, Fujji K, Sengupta M, et al: In vivo inhibition of mouse liver microsomal hydroxylating systems by methylene dioxyphenyl insecticide synergists and related compounds. Life Sci 7:1051, 1968.
Jerina DM, Yagi H, Lehr RE, et al: The Bay-Region theory of carcinogenesis by polycyclic aromatic hydrocarbons. In: Polycyclic Hydrocarbons and Cancer. Vol 1 Environment, Chemistry and Metabolism, p 173, Gelboin HV, Ts’O POP (eds.), Academic Press, New York, 1978.
Johnson EF: Multiple forms of cytochrome P450: Criteria and significance. In: Reviews in Biochemical Toxicology, p 1, Hodgson E, Bend JR, Philpot RM (eds.), Elsevier-North Holland, Amsterdam, 1979.
Dfollow DJ, Mitchell DR, Zampaglione H, et al: Bro-mobenzene-induced liver necrosis. Protective role of glutathione and evidence of 3,4-bromobenzene oxide as the hepatoxic metabolite. Pharmacology 11:151, 1974.
Jori A, Bianchett A, Prestini PE, et al: Effect of euca-lyptol (1,8-cineole) on the metabolism of other drugs in rats and in man. Eur J Pharmacol 9:362, 1970.
Juchau MR: Enzymatic bioactivation and inactivation of chemical teratogens and transplacental carcino-gens/mutagens. In: The Biochemical Basis of Chemical Teratogenesis, p 63, Juchau MR (ed.), Elsevier-North Holland, Amsterdam, 1981.
Juchau MR: Bioactivation in chemical teratogenesis. Annu Rev Pharmacol Toxicol 29:165, 1989.
Jusko WJ: Influence of cigarette smoking on drug metabolism in man. Drug Metab Rev 9:221, 1979.
Kadlubar FF, Frederick CB, Weis CC, et al: Prostaglandin endoperoxide synthetase-mediated metabolism of carcinogenic aromatic amines and their binding to DNA and proteins. Biochem Biophys Res Commun 108:253, 1982.
Kato R: Drug metabolism under pathological and abnormal physiological states in animals and man. Xenobiotica 7:25, 1977.
Kaul PM, Kulkami SK: New drug metabolism inhibitor of marine origin. J Pharm Sci 67:1293, 1978.
Kimbrough RD, Jensen AA (eds.): Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., Elsevier, Amsterdam, 1989.
Kinoshita FK, Du Bois KP: Induction of hepatic microsomal enzymes by Herban, Diuron and other substituted urea herbicides. Toxicol App Pharmacol 17: 406, 1970.
Kinoshita FK, Frawley JP, Du Bois KP: Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxa-phene in the rat. Toxicol Appl Pharmacol 9:505, 1966.
Kulkarni AR Hodgson E: The metabolism of insecticides—the role of monooxygenase enzymes. Annu Rev Pharmacol Toxicol 24:19, 1984.
Lake BG, Phillips JC, Linnell JC, et al: The in vitro hydrolysis of some phthalate diesters by hepatic and intestinal preparations, from various species. Toxicol Appl Pharmacol 39:239, 1977.
Leibman KC: Metabolism and toxicity of styrene. Environ Health Perspect 11:115, 1975.
Levin W, Welch RM, Conney AH: Effect of carbon tetrachloride and other inhibitors of drug metabolism on the metabolism and action of estradiol-17β and estrone in the rat. J Pharmacol Exp Ther 173:247, 1970.
Lu AYH, West SB: Multiplicity of mammalian microsomal cytochromes P-450. Pharmacol Rev 31:277, 1980.
Lu AYH, Levin W, Kuntzman R: Reconstituted liver microsomal enzyme system that hydoxylates drugs, other foreign compounds and endogenous substrates. VII. Stimulation of benzphetamine N-de-methylation by lipid and detergent. Biochem Bio-phys Res Commun 60:266, 1974.
Madhaven TV, Gopalan C: The effect of dietary protein on carcinogenesis of aflatoxin. Arch Pathol 85: 133, 1968.
Mathews HB, Dedrick RL: Pharmacokinetics of poly-chlorinated biphenyls. Annu Rev Pharmacol Toxicol 24:85, 1984.
Mathews HB, Kato S, Morales NM, et al: Distribution and excretion of 2,4,5,2′,4′,5′-hexabromobiphenyl, the major component of Firemaster BP-6. J Toxicol Environ Health 3:599, 1977.
McConnell EE: Acute and chronic toxicity and carcinogenesis in animals. In: Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products, 2nd ed., p 161, Kimbrough RD, Jensen AA (eds.), Elsevier, Amsterdam, 1989.
McDonald TL: Chemical mechanisms of halocarbon metabolism. CRC Crit Rev Toxicol 11:85, 1983.
Meydani M: Dietary effects on detoxification process. In: Nutritional Toxicology, Vol II, p 1, Hathcock JN (ed.), Academic Press, Orlando, 1987.
Mizokami K, Inouie K, Sunouchi M, et al: 3-Methyl-cholanthrene induces phenobarbital-induced cytochrome P-450 haemoprotein in fetal liver and not cytochrome P-448 haemoprotein induced in maternal liver of rats. Biochem Biophys Res Commun 107:6, 1982.
Mocarelli P, Marocchi A, Brambilla P, et al: Clinical laboratory manifestations of exposure to dioxin in children. JAMA 256:2687, 1986.
Moody DE, James JL, Smuckler EA: Cytochrome P-450-lowering effect of alkyl halides, correlation with decrease in arachidonic acid. Biochem Biophys Res Commun 97:673/1980.
Moody DE, Clawson GA, Woo CH, et al: Cellular distribution of cytochrome P-450 loss in rats of different ages treated with alkyl halides. Toxicol App Pharmacol 66:278, 1982.
Moore RW, Dannan GA, Aust SD: Structure-function relationships for the pharmacological and tox-icological effects and metabolism of polybrominated biphenyl congeners. In: Molecular Basis of Environmental Toxicity, p 173, Bhatnagar RS (ed.), Ann Arbor Science, Ann Arbor, 1980.
Nebert DW, Jensen NM: The Ah locus: Genetic regulation of the metabolism of carcinogens, drugs and other environmental chemicals by cytochrome P-450-mediated monooxygenases. CRC Crit Rev Biochem 6:401, 1979.
Nebert DW, Kumaki K, Sato M, et al: Association of type I, type II and reverse type I difference spectra with absolute spin state of cytochrome P-450 iron. In: Microsomes and Drug Oxidations, p 224, Ullrich V, Roots A, Hildebrandt A, et al. (eds.), Pergamon Press, New York, 1977.
Nebert DW, Eisen HK, Negishi M, et al: Genetic mechanisms controlling the induction of polysub-strate monooxygenase (p-450) activities. Annu Rev Pharmacol Toxicol 21:431, 1981.
Nebert DW, Nelson DR, Adesnik M, et al: The P450 superfamily: Updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA 8:1, 1989.
Nowicki HG, Norman AW: Enhanced hepatic metabolism of testosterone, 4-androstene-3, 17-dione and oestradiol-17β in chickens pretreated with DDT or polychlorinated biphenyls. Steroids 19:85, 1972.
Obreska MJ, Kentish P, Parke DV: The effects of carbon disulphide on rat liver microsomal mixed function oxidases, in vivo and in vitro. Biochem J 188: 107, 1980.
Oesch F, Guenthner TM: Effects of the modulation of epoxide hydrolase activity on the binding of benzo-[a]pyrene metabolites to DNA in the intact nuclei. Carcinogenesis 4:57, 1983.
Okey AB, Vella LM: Binding of 3-methylcholan-threne and 2,3,7,8-tetrachlorodibenzo-p-dioxin to a common Ah receptor site in mouse and rat hepatic cytosols. Eur J Biochem 127:39, 1982.
Okey AB, Bondy GT, Mason ME, et al: Regulatory product of the Ah locus. Characterisation of the inducer-recepter complex and evidence for its nuclear translocation. J Biol Chem 254:11636, 1979.
Ortiz de Montellano PR, Mico BA: Destruction of cytochrome P-450 by ethylene and other olefins. Mol Pharmacol 18:128, 1980.
Ozawa N, Yoshihara S, Yoshimura H: Selective induction of rat liver microsomal cytochrome P-448 by 3,4,5,3′,4′-pentachlorobiphenyl and its effect on liver microsomal drug metabolism. J Pharm Dyn 2:309, 1979.
Panthananickal A, Weiler P, Marnett LJ: Stereoselectivity of the epoxidation of 7,8-dihydrobenzo[a]py-rene by prostaglandin H synthase and cytochrome P-450 determined by the identification of polygua-nylic acid adducts. J Biol Chem 258:4411, 1983.
Parke DV: The Biochemistry of Foreign Compounds, Pergamon Press, New York, 1968.
Parke DV: The disposition and metabolism of environmental chemicals by mammalia. In: Handbook of Environmental Chemistry, p 141, Hutzinger O (ed.), Springer-Verlag, New York, 1982.
Parke DV: Activation mechanisms to chemical toxicity. Arch Toxicol 60:5, 1987.
Parke DV: The role of enzymes in protection mechanisms for human health. Regul Toxicol Pharmacol 7: 222, 1987.
Parke DV, Ioannides C: The role of nutrition in toxicology. Annu Rev Nut 1:207, 1981.
Parke DV, Ioannides C, Lewis DFV: Metabolic activation of carcinogens and toxic chemicals. Human Toxicol 7:397, 1988.
Parkinson A, Safe SH, Robertson LW, et al: Immunochemical quantition of cytochrome P-450 isoenzymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. J Biol Chem 258:5967, 1983.
Pelkonen O, Nebert DW: Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis. Pharmacol Rev 34:189, 1982.
Poiger H, Schlatter C: Biological degradation of TCDD in rats. Nature 281:706, 1979.
Poland A, Smith D, Kuntzman R, et al: Effect of intensive occupational exposure to DDT on phenylbutazone and Cortisol metabolism in human subjects. Clin Pharmacol Ther 11:724, 1970.
Radomski JL: The primary aromatic amines: Their biological properties and structure-activity relationships. Annu Rev Pharmacol Toxicol 19:129, 1979.
Reed DJ, Beatty PW: Biosynthesis and regulation of glutathione: Toxicological implications. Rev Biochem Toxicol 2:213, 1980.
Reed GA, Marnett L): Metabolism and activation of 7,8-dihydrobenzo(a)pyrene during prostaglandin biosynthesis. Intermediacy of a bay region epoxide. J Biol Chem 257:11368, 1982.
Reggiani G: An overview of the health effects of halogenated dioxins and related compounds—the Yusho and Taiwan episodes. In: Accidental Exposure to Dioxins. Human Health Aspects, p 39, Coulston F, Pocchiari F (eds.), Academic Press, Orlando, 1983.
Reynolds ED, Moslen MT: Metabolic activation and hepatotoxicity of trichloroethylene. In: Biological Reactive Intermediates, 2, Chemical Mechanisms and Biological Effects (Part A), p 693, Snyder R, Parke DV, Kocsis JJ, et al. (eds.), Plenum Press, New York, 1982.
Rogers AE, Newberne PM: Diet and aflatoxin B1 toxicity in rats. Toxicol Appl Pharmacol 20:113, 1971.
Safe S: Polychlorinated biphenyls (PCBs) and poly-brominated biphenyls (PBBs): Biochemistry, toxicology and mechanism of action. CRC Crit Rev Toxicol 13:319, 1984.
Safe S, Campbell MA, Lambert I, et al: Polychlorinated biphenyls as phenobarbital-type inducers: Structure activity correlations. In: Cytochrome P-450, Biochemistry, Biophysics and Environmental Implications, p 341, Hietanen E, Laitinen M, Hanninen O (eds.), Elsevier-North Holland, Amsterdam, 1982.
Sasame HA, Boyd MR: Paradoxical effects of co-baltous chloride and salts of other divalent metals on tissue levels of reduced glutathione and microsomal mixed function oxidase components. J Pharmacol Exp Ther 205:718, 1978.
Seutter-Berlage F, Rietveld EC, Plate R, et al: Mercap-turic acids as metabolites of aromatic aldehydes and alcohols. In: Biological Reactive Intermediates 2. Chemical Mechanisms and Biological Effects, Part A, p 359, Snyder R, Parke DV, Kocsis JJ, et al. (eds.), Plenum Press, New York, 1982.
Sinclair JF, Sinclair PR, Healey JF, et al: Decrease in hepatic cytochrome P-450 by cobalt. Biochem J 204: 103, 1982.
Snyder R, Lee EW, Kocsis JJ, et al: Bone marrow depressant and leukemongenic actions of benzene. Life Sci 21:1709, 1977.
Snyder R, Longacre SL, Witmer CM, et al: Biochemical toxicology of benzene. In: Reviews in Biochemical Toxicology 3, p 123, Hodgson E, Bend JR, Philpot RM (eds.), Elsevier-North Holland, Amsterdam, 1981.
Snyder R, Longacre SL, Witmer CM, et al: Metabolic correlate of benzene toxicity. In Biological Reactive Intermediates 2. Chemical Mechanisms and Biological Effects, Part A, p 245, Snyder R, Parke DV, Kocsis JJ/ et al. (eds), Plenum Press, New York, 1982.
Testa B: Structural and electronic factors influencing the inhibition of aniline hydroxylation by alcohols and their binding to cytochrome P-450. Chem Biol Interact 12:1, 1976.
Testa B, Jenner P: Inhibitors of cytochrome P-450 and their mechanism of action. Drug Metab Rev 12:1, 1981.
Testai E, Citri L, Gervasi PG, et al: Suicidal inactiva-tion of hepatic cytochrome P-450 in vitro by some aliphatic olefins. Biochem Biophys Res Commun 107: 633, 1982.
Thor H, Svensson SA, Hartzell P, et al: Biotransformation of bromobenzene to reactive metabolites by isolated hepatocytes. In: Biological Reactive Intermediates 2. Chemical Mechanisms and Biological Effects, Part A, p 287, Snyder R, Parke DV, Kocsis JJ, et al. (eds.), Plenum Press, New York, 1982.
Vainio H, Norppa H, Hemminki K, et al: Metabolism and genotoxicity of styrene. In: Biological Reactive Intermediates 2. Chemical Mechanisms and Biological Effects. Part A, p 257, Snyder R, Parke DV, Kocsis JJ, et al. (eds.), Plenum Press, New York, 1982.
Vessell ES: Complex effects of diet on drug disposition. Clin Pharmacol 36:285, 1984.
Vos JG, Luster MI: Immune alterations. In: Halogenated Biphenyls, Terphenyls, Naphthalenes, Di-benzodioxins and Related Products, 2nd ed, p 295, Kimbrough RE, Jensen AA (eds.), Elsevier, Amsterdam, 1989.
Wattenberg LW: Inhibitors of chemical carcinogens. In: Environmental Carcinogenesis, p 241, Emmelot P, Kriek E (eds.), Elsevier/North-Holland Biomedical Press, Amsterdam, 1979.
Wattenberg LW: Inhibition of chemical carcinogens by antioxidants. In: Carcinogens, Vol 5, Modifiers of Chemical Carcinogenesis, p 85, Slaga Tf (ed.), Raven Press, New York, 1980.
Wattenberg LW: Inhibition of carcinogenesis by naturally occurring and synthetic compounds. Basic Life Sci 52:155, 1990.
Wattenberg LW, Loub WD: Inhibition of polycyclic hydrocarbon-induced neoplasia by naturally occurring indoles. Cancer Res 38:1410, 1978.
Wattenberg LW, Leong JC, Strand PJ: Benzo(a)pyrene hydroxylase activity in the gastrointestinal tract. Cancer Res 22:1120, 1962.
Wattenberg LW, Coccia JB, Cam LKT: Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia. Cancer Res 40:2820, 1980.
Wattenberg LW, Borchert P, Destafry CLM, et al: Effects of p-methoxyphenol and diet on carcinogen-induced neoplasia of the mouse forestomach. Cancer Res 43:4747, 1983.
Webb M: Role of metallothioneins and other binding proteins in the renal handling and toxicity of heavy metals. In: Nephrotoxicity: Assessment and Pathogenesis, p 25, Bach PH, Bonner FW, Bridges JW, et al. (eds.), John Wiley & Sons, New York, 1982.
Weisburger E: Carcinogenicity studies on halogenated hydrocarbons. Environ Health Perspect 21:7, 1977.
Welch RM, Levin W, Conney AH: Insecticide inhibition and stimulation of steroid hydroxylases in rat liver. J Pharmacol Exp Ther 155:167, 1967.
Wenzel DG, Broadie LL: Stimulatory effect of nicotine on the metabolism of meprobamate. Toxicol Appl Pharmacol 8:455, 1966.
White INH: Metabolic activation of acetylenic substi-tuents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem. Biochem J 174: 853, 1980.
World Health Organization: Evaluation of carcinogenic risk of chemicals to man. Some aromatic amines, hydrazine and related substances, N-nitroso compounds and miscellaneous alkylating agents. IARC Monogr 4:27, 1974.
Wiener M, Pittman KA, Stein V: Mirex kinetics in the rhesus monkey. I. Disposition and Excretion. Drug Metab Dispos 4:281, 1978.
Williams RT: Detoxication Mechanisms, 2nd ed., Chapman and Hall, London, 1959.
Wills ED: The role of polyunsaturated fatty acid composition of the endoplasmic reticulum in the regulation of the rate of oxidative carcinogen metabolism. In: Microsomes, Drug Oxidations and Chemical Carcinogenesis. Vol I, p 545, Coon MJ, Conney AH, Esta-brook RW, et al. (eds.), Academic Press, Orlando, 1980.
Wolff T, Hesse S: Species differences of mixed function oxidase induction between rabbits and rats after pretreatment with polychlorinated biphenyls. Bio-chem Pharmacol 26:783, 1977.
Yoshihara S, Nagata K, Wada I, et al: A unique change of steroid metabolism in rat liver microsomes induced with a highly toxic polychlorinated biphenyl and polychlorinated dibenzofuran. J Pharm Dyn 5: 994, 1982.
Recommended Readings
Gibson GG, Skett P: Introduction to Drug Metabolism, Chapman and Hall, London, 1986.
Meydani M: Dietary Effects on Detoxification Processes. In: Nutritional Toxicology, Vol II, p 1, Hathcock JN (ed.), Academic Press, Orlando, 1987.
Parke DV: Activation mechanisms to chemical toxicity. Arch Toxicol 60:5, 1987.
Parke DV: The role of enzymes in protection mechanisms for human health. Regul Toxicol Pharmacol 7:222, 1987.
Parke DV, Ioannides C: The role of nutrition in toxicology. Annu Rev Nutr 1:207, 1981.
Timbrell JA: Principles of Biochemical Toxicology, 2nd Ed. Taylor & Francis, London, 1991.
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Gibson, G.G. (1992). Detoxication Mechanisms and the Role of Nutrition. In: Tarcher, A.B. (eds) Principles and Practice of Environmental Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2447-6_9
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