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Abstract

A large variety of naturally occurring and man-made compounds pose the danger of thyroid disease by interfering with thyroid function. These compounds can alter thyroid structure and function by acting directly on the gland or by affecting its regulatory mechanisms. The gland may increase in size to become a goiter. Thyroid hormone secretion may remain adequate or become insufficient, depending on dietary iodine intake or the presence of underlying thyroid disease.

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References

  1. Allen-Rowlands CR, Castracane VD, Hamilton MF, et al: Effect of polybrominated biphenyls (PBB) on the pituitary-thyroid axis of the rat. Proc Soc Exp Biol Med 166:506, 1981.

    PubMed  CAS  Google Scholar 

  2. Andelman JB, Sness MJ: Polynuclear aromatic hydrocarbons in the water environment. Bull WHO 43:479, 1970.

    PubMed  CAS  Google Scholar 

  3. Arnott DG, Doniach I: The effects of compound allied to resorcinol upon the uptake of radioactive iodine (131 I) by the thyroid of the rat. Biochem J 50: 473, 1952.

    PubMed  CAS  Google Scholar 

  4. Bahn AK, Mills JL, Synder PJ, et al: Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med 302:31, 1980.

    PubMed  CAS  Google Scholar 

  5. Barsano CP: Environmental factors altering thyroid function and their assessment. Environ Health Per-spect 38:71, 1981.

    CAS  Google Scholar 

  6. Barsano CP: Polyhalogenated and polycyclic aromatic hydrocarbons. In: Environmental Goitrogen-esis, p 115, Gaitan E (ed.), CRC Press, Boca Raton, 1989.

    Google Scholar 

  7. Bastomsky CH: Goiters in rats fed polychlorinated biphenyls. Can J Physiol Pharmacol 55:288, 1977.

    PubMed  CAS  Google Scholar 

  8. Bastomsky CH, Murphy PVN, Banovac K: Alterations in thyroxine metabolism produced by cutaneous application of microscope immersion oil. Effects due to polychlorinated biphenyls. Endocrinology 98:1309, 1976.

    PubMed  CAS  Google Scholar 

  9. Becker DV, Braverman LE, Dunn JT, et al: The use of iodine as a thyroidal blocking agent in the event of a reactor accident. Report of the Environmental Hazards Committee of the American Thyroid Association. JAMA 252:659, 1984.

    PubMed  CAS  Google Scholar 

  10. Bekesi JG, Roboz JP, Solomon S, et al: Altered immune function in Michigan residents exposed to polybrominated biphenyls. In: Immunotoxicology, p 182, Gibson GG, Hubbard R, Parke DV (eds.), Academic Press, Orlando, 1983.

    Google Scholar 

  11. Black AP, Christman RF: Chemical characteristics of fulvic acids. J Am Water Works Assoc 55:897, 1963.

    CAS  Google Scholar 

  12. Brass HJ, Feige MA, Halloran T, et al: The national organic monitoring survey: A sampling and analysis for purgeable organic compounds. In: Drinking Water Quality Enhancement through Source Protection, p 393, Pojasek RB (ed.), Ann Arbor Science, Ann Arbor, 1977.

    Google Scholar 

  13. Buckley EH: Accumulation of airborne polychlorinated biphenyls in foliage. Science 216:520, 1982.

    PubMed  CAS  Google Scholar 

  14. Bull GM, Fraser R: Myxoedema from resorcinol ointment applied to leg ulcers. Lancet 1:851, 1950.

    PubMed  CAS  Google Scholar 

  15. Burges NA, Hurst HM, Walkden B: The phenolic constituents of humic acid and their relationship to the lignin of the plant cover. Geochem Cosmol Acta 28:1547, 1964.

    CAS  Google Scholar 

  16. Castor CM, Beierwaltes WH: Depression of serum protein-bound iodine levels in man with dinitro-phenol. J Clin Endocrinol Metab 15:862, 1955.

    Google Scholar 

  17. Choudry GG: Humic substances: Part 1: Structural aspects. Toxicol Environ Chem 4:209, 1981.

    Google Scholar 

  18. Christman RF, Chassemi N: Chemical nature of organic color in water. J Am Water Works Assoc 58:723, 1966.

    CAS  Google Scholar 

  19. Christov K, Raichev R: Experimental thyroid carcinogenesis. Curr Top Pathol 56:79, 1973.

    Google Scholar 

  20. Committee on the Biological Effects of Ionizing Radiations, National Research Council: Health Effects of Exposure to Low Levels of Ionizing Radiation. BIER V, National Academy Press, Washington, 1990.

    Google Scholar 

  21. Cooksey RC, Gaitan E, Lindsay RH, et al: Humic substances, a possible source of environmental goitrogens. Org Geochem 8:77, 1985.

    CAS  Google Scholar 

  22. Cordle F, Locke R, Springer J: Risk assessment in a federal regulatory agency: An assessment of risk associated with the human consumption of some species of fish contaminated with polychlorinated biphenyls (PCBs). Environ Health Perspect 45:171, 1982.

    PubMed  CAS  Google Scholar 

  23. Cowan JW, Saghir AR, Salji JP: Antithyroid activity of onion volatiles. Aust J Biol Sci 20:683, 1967.

    PubMed  CAS  Google Scholar 

  24. Cuello C, Correa P, Eisenberg H: Geographic pathology of thyroid carcinoma. Cancer 23:230, 1969.

    PubMed  CAS  Google Scholar 

  25. Daniel JW: Toxicity and metabolism of phthalate esters. Clin Toxicol 13:257, 1978.

    PubMed  CAS  Google Scholar 

  26. DeGroot LJ: Thyroid gland. In: Endocrinology Vol I, p 305, DeGroot LJ, Cahill GH Jr, Martini L, et al. (eds.), Grune & Stratton, New York, 1979.

    Google Scholar 

  27. DeGroot LJ, Reilly M, Pinnameneni K, et al: Retrospective and prospective study of radiation-induced thyroid disease. Am J Med 74:852, 1983.

    PubMed  CAS  Google Scholar 

  28. Delange F, Ahluwalia R (eds.): Cassava Toxicity and Thyroid: Research and Public Health Issues. International Development Research Centre (IDRC-207e), Ottawa, 1983.

    Google Scholar 

  29. Doniach I: Experimental thyroid tumors. In: Tumours of the Thyroid Gland. Neoplastic Diseases at Various Sites, Vol VI, p 73, Smither DW (ed.), Liv-instone, Edinburgh, 1970.

    Google Scholar 

  30. Doniach I, Fraser R: Effects of resorcinol in the thyroid uptake of 131I in rats. Lancet 1:855, 1950.

    PubMed  CAS  Google Scholar 

  31. Doniach I, Logothetopoulos J: The goitrogenic action of resorcinol in rats. Br J Exp Pathol 34:146, 1953.

    PubMed  CAS  Google Scholar 

  32. Engelhardt G, Wallnofer PR, Hutzinger O: The microbial metabolism of di-w-butyl phthalate and related dialkyl phthalates. Bull Environ Contam Toxicol 13:342, 1975.

    CAS  Google Scholar 

  33. Farook MA: Observations on the epidemiology, histology and classification of thyroidal nodules and adenomas. Int Surg 50:540, 1968.

    Google Scholar 

  34. Fishbein L: Toxicity of chlorinated biphenyls. Annu Rev Pharmacol 14:139, 1974.

    CAS  Google Scholar 

  35. Friedman EA, Lundin AP: Environmental and iatrogenic obstacles to long life on hemodialysis. N Engl J Med 306:167, 1982.

    PubMed  CAS  Google Scholar 

  36. Gaitan E: Water-borne goitrogens and their role in the etiology of endemic goiter. World Rev Nutr Diet 17: 53, 1973.

    PubMed  CAS  Google Scholar 

  37. Gaitan E: Iodine deficiency and toxicity. In: Proceedings Western Hemisphere Nutrition Congress IV, p 56, White PL, Selvey N (eds.), Publishing Sciences Group, Acton, Mass., 1975.

    Google Scholar 

  38. Gaitan E: Goitrogens in the etiology of endemic goiter. In: Endemic Goiter and Endemic Cretinism, p 219, Stanbury JB, Hetzel B (eds.), John Wiley & Sons, New York, 1980.

    Google Scholar 

  39. Gaitan E, Lindsay RH, Cooksey RC, et al: Antithyroid activities of resorcinol and its methyl and chloro derivatives present in effluents from coal liquefaction and chlorinated domestic sewage plants. In: Proceedings American Thyroid Association, ATA, Quebec, 1982.

    Google Scholar 

  40. Gaitan E: Endemic goiter in western Colombia. Ecol Dis 2:295, 1984.

    Google Scholar 

  41. Gaitan E: Iodine-sufficient goiter and autoimmune thyroiditis: The Kentucky and Colombian experience. In: Frontiers in Thyroidology, p 19, Medeiros-Neto G, Gaitan E (eds.), Plenum Press, New York, 1986.

    Google Scholar 

  42. Gaitan E: Symposium on thyroid disorders: Possible role of environmental pollutants and naturally-occurring agents. Am Chem Soc Div Environ Chem 26:58–85, 1986.

    Google Scholar 

  43. Gaitan E: Goitrogens. Bailliere Clin Endocrinol Metab 2:683, 1988.

    CAS  Google Scholar 

  44. Gaitan E: Environmental Goitrogenesis, CRC Press, Boca Raton, 1989.

    Google Scholar 

  45. Gaitan E: Phthalate esters and phthalic acid derivatives. In: Environmental Goitrogenesis, p 107, Gaitan E (ed.), CRC Press, Boca Raton, 1989.

    Google Scholar 

  46. Gaitan E: Goitrogens in food and water. Annu Rev Nutr 10:21, 1990.

    PubMed  CAS  Google Scholar 

  47. Gaitan E, Island DP, Liddle GW: Identification of a naturally occurring goitrogen in water. Trans Assoc Am Physicians 82:141, 1969.

    PubMed  CAS  Google Scholar 

  48. Gaitan E, Wahner HW, Cuello C, et al: Endemic goiter in the Cauca Valley, II. Studies of thyroid pathophysiology. J Clin Endocrinol 29:675, 1969.

    CAS  Google Scholar 

  49. Gaitan E, Merino H, Rodriquez G, et al: Epidemiology of endemic goiter in western Colombia. Bull WHO 56:403, 1978.

    PubMed  CAS  Google Scholar 

  50. Garton GA, Williams RT: Studies in detoxication. 21. The fates of quinol and resorcinol in the rabbit in relation to the metabolism of benzene. Biochem J 44: 234, 1949.

    CAS  Google Scholar 

  51. Goldberg RC, Wolff J, Greep RO: The mechanism of depression of plasma protein bound iodine by 2,4-dinitrophenol. Endocrinology 56:560, 1955.

    PubMed  CAS  Google Scholar 

  52. Goldberg RC, Wolff J, Greep RO: Studies on the nature of the thyroid-pituitary interrelationship. Endocrinology 60:38, 1957.

    PubMed  CAS  Google Scholar 

  53. Goodman LS, Gilman A, Gilman AG (eds.): Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 7th ed., Macmillan, New York, 1985.

    Google Scholar 

  54. Greene G, Steelink C: Structure of soil humic acid II. Some copper oxide oxidation products. J Org Chem 27:170, 1962.

    CAS  Google Scholar 

  55. Hartenstein R: Sludge decomposition and stabilization. Science 212:743, 1981.

    PubMed  CAS  Google Scholar 

  56. Hedinger CE (ed.): Thyroid Cancer, Vol 12, UICC Monograph Series. Springer-Verlag, Berlin, 1969.

    Google Scholar 

  57. Hollingsworth DR, Butcher LK, White SD: Kentucky Appalachian goiter without iodine deficiency. Am J Dis Child 131:866, 1977.

    PubMed  CAS  Google Scholar 

  58. Ingbar SH, Braverman LE (eds.): Werner’s The Thyroid, 5th ed., JB Lippincott, Philadelphia, 1986.

    Google Scholar 

  59. Jahnig CE, Bertrand RR: Aqueous effluents from coal-conversion processes. Chem Eng Prog 72:51, 1976.

    CAS  Google Scholar 

  60. Jefferies DJ, French MC: Avian thyroid: Effects of pp’ DDT on size and activity. Science 166:1278, 1969.

    PubMed  CAS  Google Scholar 

  61. Jefferies DJ, French MC: Hyper- and hypo-thyroid-ism in pigeons fed DDT: An explanation for the “thin eggshell” phenomenon. Environ Pollut 1:235, 1971.

    Google Scholar 

  62. Jefferies DJ, French MC: Changes induced in the pigeon thyroid by pp’DDT and dieldrin. J Wildl Mgmt 36:24, 1972.

    CAS  Google Scholar 

  63. Jefferies DJ, Parslow JLF: Effect of one polychlori-nated biphenyl on size and activity of gull thyroid. Bull Environ Contam Toxicol 8:306, 1972.

    PubMed  CAS  Google Scholar 

  64. Jolley RL, Gorchev H, Hamilton DH Jr: Analysis of organic constituents in natural and process waters by high-pressure liquid chromatography. In: Trace Substances in Environmental Health—XI, p 247, Hemphill DD (ed.), The University of Missouri, Columbia, 1975.

    Google Scholar 

  65. Jolley RL, Gorchev H, Hamilton DH Jr (eds.): Water Chlorination: Environmental Impact and Health Effects, Vol 2, Ann Arbor Science, Ann Arbor, 1978.

    Google Scholar 

  66. Jolley RL, Gaitan E, Lee NE, et al: Resorcinol, a potent antithyroid compound, detected in the water supply of a Colombian district with endemic goiter. Am Chem Soc Div Environ Chem 23:179, 1983.

    Google Scholar 

  67. Keyser P, Basayya GP, Eaton RW, et al: Biodegradation of the phthalates and their esters by bacteria. Environ Health Perspect 18:159, 1976.

    PubMed  CAS  Google Scholar 

  68. Kieffer JD, Vickery AL Jr, Ridgway EC, et al: Induction of breast cancer by nitrosomethylurea in rats of the Buffalo strain: Frequent association with thyroid disease. Endocrinology 107:1218, 1980.

    PubMed  CAS  Google Scholar 

  69. Kimbrough RD: The toxicity of polychlorinated compounds and related chemicals. CRC Crit Rev Toxicol 2:445, 1974.

    PubMed  CAS  Google Scholar 

  70. Klibanov AM, Tu TM, Scott KP: Peroxidase-catalyzed removal or phenols from coal-conversion waste waters. Science 221:259, 1983.

    PubMed  CAS  Google Scholar 

  71. Kreiss K, Roberts C, Humphrey HEB: Serial PBB levels, PCB levels, and clinical chemistries in Michigan’s PBB cohort. Arch Environ Health 37:141, 1982.

    PubMed  CAS  Google Scholar 

  72. Kuratsune M, Shapiro RE (eds.): PCB Poisoning in Japan and Taiwan. Progress in Clinical and Biological Research, Vol 137, Alan R Liss, New York, 1984.

    Google Scholar 

  73. Langer P, Greer MA (eds.): Antithyroid Substances and Naturally Occurring Goitrogens. S Karger, Basel, 1977.

    Google Scholar 

  74. Lawrence WH, Tuell SF: Phthalate esters: The question of safety—an update. Clin Toxicol 15:447, 1979.

    PubMed  CAS  Google Scholar 

  75. Leftwich RB, Floro JF, Neal RA, et al: Dinitrophenol poisoning: A diagnosis to consider in undiagnosed fever. South Med J 75:182, 1982.

    PubMed  CAS  Google Scholar 

  76. Lim VS, Fang VS, Katz AL, et al: Thyroid dysfunction in chronic renal failure. J Clin Invest 60:522, 1977.

    PubMed  CAS  Google Scholar 

  77. London WT, Koutras DA, Pressman A, et al: Epidemiology and metabolic studies of a goiter endemic in eastern Kentucky. J Clin Endocrinol Metab 25:1091, 1965.

    PubMed  CAS  Google Scholar 

  78. Luthy RD, Talion JT: Biological treatment of coal gasification process waste water. Water Res 14:1269, 1980.

    CAS  Google Scholar 

  79. Marx JL: Phthalic acid esters: Biological impact uncertain. Science 178:46, 1972.

    PubMed  CAS  Google Scholar 

  80. Maxon HR, Thomas SR, Saenger EL, et al: Ionizing irradiation and the induction of clinically significant disease in the human thyroid gland. Am J Med 63: 967, 1977.

    PubMed  CAS  Google Scholar 

  81. Mayer FL, Stalling DL, Johnson JL: Phthalate esters as environmental contaminants. Nature 238:411, 1972.

    PubMed  CAS  Google Scholar 

  82. Merker PC, Young D, Doughty D, et al: Pharmacokinetics of resorcinol in the rat. Res Commun Chem Pathol Pharmacol 38:367, 1982.

    PubMed  CAS  Google Scholar 

  83. Metcalf RL, Booth GM, Schuth CK, et al: Uptake and fate of di-2-ethylhexyl phthalate in aquatic organisms and in a model ecosystem. Environ Health Perspect 4:27, 1973.

    PubMed  CAS  Google Scholar 

  84. Meyer JD, Gaitan E, Merino H, et al: Geologic implications on the distribution of goiter in Colombia, SA. Int J Epidemiol 7:25, 1978.

    PubMed  CAS  Google Scholar 

  85. Moccia RD, Leatherland JF, Sonstegard RA: Increasing frequency of thyroid goiters in Coho salmon (Oncorhynchus kisutch) in the Great Lakes. Science 198:425, 1977.

    PubMed  CAS  Google Scholar 

  86. Moccia RD, Leatherland JF, Sonstegard RA: Quantitative interlake comparison of thyroid pathology in Great Lakes Coho (Ortcorhychus kisutch) and chinook (Oncorhynchus tschawytscha) salmon. Cancer Res 41: 2200, 1981.

    PubMed  CAS  Google Scholar 

  87. Morris SC, Moskowitz PD, Sevian WA, et al: Coal-conversion technologies: Some health and environmental effects. Science 206:654, 1979.

    PubMed  CAS  Google Scholar 

  88. Morrison RT, Boyd RM (eds.): Organic Chemistry, 3rd ed., Allyn and Bacon, Boston, 1978.

    Google Scholar 

  89. Nemeth S: Short-term decrease of serum protein-bound iodine concentration after administration of 2,4-dinitro-phenol in man. J Clin Endocrinol Metab 18:225, 1958.

    PubMed  CAS  Google Scholar 

  90. Peakall DB: Phthalate esters: Occurrence and biological effects. Residue Rev 54:1, 1975.

    PubMed  CAS  Google Scholar 

  91. Pelkonen O, Nebert DW: Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis. Pharmacol Rev 34:189, 1982.

    PubMed  CAS  Google Scholar 

  92. Pendergrast WT, Milmore BK, Marcus SC: Thyroid cancer and thyrotoxicosis in the United States. Their relationship to endemic goiter. J Chron Dis 13:22, 1961.

    PubMed  CAS  Google Scholar 

  93. Perry H: Coal in the United States: A status report. Science 222:377, 1983.

    PubMed  CAS  Google Scholar 

  94. Pitt WW, Jolley RL, Jones G: Characterization of or-ganics in aqueous effluents of coal-conversion plants. Environ Int 2:167, 1979.

    CAS  Google Scholar 

  95. Proceedings of the Conference on PCBs: Environ Health Perspect 45:1, 1982.

    Google Scholar 

  96. Proceedings of the Conference on Phthalates: Environ Health Perspect 45:1, 1982.

    Google Scholar 

  97. Prue DM, Martin JE, Hume AS: A critical evaluation of thiocyanate as a biochemical index of smoking exposure. Behav Ther 11:368, 1980.

    Google Scholar 

  98. Prue DM, Martin JE, Hume AS, et al: The reliability of thiocyanate measurement of smoking exposure. Addict Behav 6:99, 1981.

    PubMed  CAS  Google Scholar 

  99. Quentin JG, Hobson BM: Varicose ulceration of the legs and myxoedema and goiter following application of resorcinol ointment. Proc R Soc Med 44:164, 1951.

    Google Scholar 

  100. Rall DP: The invisible pollution. N Engl J Med 287: 1146, 1972.

    PubMed  CAS  Google Scholar 

  101. Ramirez G, Jubiz W, Gutch CF, et al: Thyroid abnormalities in renal failure: A study of 53 patients on chronic hemodialysis. Ann Intern Med 79:500, 1973.

    PubMed  CAS  Google Scholar 

  102. Reed-Larsen P: Thyroid-pituitary interaction. N Engl J Med 306:23, 1982.

    Google Scholar 

  103. Ribbons WW, Evans WC: Oxidative metabolism of phthalic acid by soil pseudomonads. J Biochem 76: 310, 1960.

    CAS  Google Scholar 

  104. Rogan WJ, Bagniewska A, Damstra T: Pollutants in breast milk. N Engl J Med 30:1450, 1980.

    Google Scholar 

  105. Rook JJ: Chlorination reaction of fulvic acids in natural waters. Environ Sci Tech 11:478, 1977.

    CAS  Google Scholar 

  106. Rosenberg N: The antithyroid activity of some compounds that inhibit peroxidase. Science 115:503, 1952.

    Google Scholar 

  107. Roti E, Grundi A, Braverman LE: The placental transport, synthesis and metabolism of hormones and drugs which affect thyroid function. Endocr Rev 4:11, 1983.

    Google Scholar 

  108. Safe Drinking Water Committee, National Research Council: Drinking Water and Health, Vol 1, National Academy Press, Washington, 1977.

    Google Scholar 

  109. Safe Drinking Water Committee, National Research Council: Drinking Water and Health, Vol 2, National Academy Press, Washington, 1980.

    Google Scholar 

  110. Safe Drinking Water Committee, National Research Council: Drinking Water and Health, Vol 3, National Academy Press, Washington, 1980.

    Google Scholar 

  111. Safran M, Paul TL, Roti E, et al: Environmental factors affecting autoimmune thyroid disease. Endocrinology Metab Clin North Am 16:327, 1987.

    CAS  Google Scholar 

  112. Saghir AR, Cowan JW, Salji JP: Goitrogenic activity of onion volatiles. Nature 211:87, 1966.

    PubMed  CAS  Google Scholar 

  113. Saghir AR, Cowan JW, Salji JP: The molecular structure of sulphides in relation to antithyroid activity. Eur J Pharmacol 2:399, 1968.

    PubMed  CAS  Google Scholar 

  114. Schneider AB, Favus MJ, Stachura ME, et al: Incidence, prevalence and characteristics of radiation-induced thyroid tumors. Am J Med 64:243, 1978.

    PubMed  CAS  Google Scholar 

  115. Schnitzer M, Khan S (eds.): Humic Substances in the Environment, Marcel Dekker, New York, 1972.

    Google Scholar 

  116. Sonstegard R, Leatherland JF: The epizootiology and pathogenesis of thyroid hyperplasia in Coho salmon (Oncorchynchus kisutch) in Lake Ontario. Cancer Res 36:4467, 1976.

    PubMed  CAS  Google Scholar 

  117. Stanbury JB, Hetzel B (eds.): Endemic Goiter and Endemic Cretinism, John Wiley & Son, New York, 1980.

    Google Scholar 

  118. Surks MI: Laboratory aids in the diagnosis of hypothyroidism. Thyroid Today 1:4, 1977.

    Google Scholar 

  119. Taurog A: Biosynthesis of iodoamino acids. In: Handbook of Physiology, Section 7, Vol 3, p 101, Greer MA, Solomon DH (eds.), Williams & Wilkins, Baltimore, 1974.

    Google Scholar 

  120. Train RE: The environment today. Science 201:320, 1978.

    PubMed  CAS  Google Scholar 

  121. Trowbridge FL, Hand KE, Nichaman MZ: Findings relating to goiter and iodine in the ten-state nutrition survey. Am J Clin Nutr 28:712, 1975.

    PubMed  CAS  Google Scholar 

  122. Trowbridge FL, Matovinovic J, McLaren GD, et al: Iodine and goiter in children. Pediatrics 56:82, 1975.

    PubMed  CAS  Google Scholar 

  123. Tunbridge WG: Screening for thyroid disease in the community. Thyroid Today 5:5, 1982.

    Google Scholar 

  124. Twort JM, Twort CC: Disease in relation to carcinogenic agents among 60,000 experimental mice. J Pathol Bacterid 35:219, 1932.

    CAS  Google Scholar 

  125. US Committee for Energy Awareness: Energy options. C310/100, P.O. Box 37012, Washington, DC 20013, 1983.

    Google Scholar 

  126. Vander JB, Gaston EA, Dawber TR: The significance of nontoxic thyroid nodules. A final report of a 15-year study of the incidence of thyroid malignancy. Ann Intern Med 69:537, 1968.

    PubMed  CAS  Google Scholar 

  127. Van Herle AJ (Moderator), Rich P, Ljung B-M E, Ashcraft MW, et al. (discussants): The thyroid nodule. Ann Intern Med 96:221, 1982.

    Google Scholar 

  128. Vidor GI, Stewart JC, Wall JR, et al: Pathogenesis of iodine-induced thyrotoxicosis. Studies in northern Tasmania. J Clin Endocrinol 37:901, 1973.

    CAS  Google Scholar 

  129. Vought RL, London WT, Stebbing GE: Endemic goiter in northern Virginia. J Clin Endocrinol Metab 27: 1381, 1967.

    PubMed  CAS  Google Scholar 

  130. Warmer HW, Cuello C, Correa P, et al: Thyroid carcinoma in an endemic goiter area, Cali Colombia. Am J Med 49:58, 1966.

    Google Scholar 

  131. Walfish PG: Drug and environmentally induced neonatal hypothyroidism. In: Congenital Hypothyroidism, p 303, Dussault JH, Walter P (eds.), Marcel Dekker, New York, 1983.

    Google Scholar 

  132. Walker CR: Pre-1972 knowledge on nonhuman effects of polychlorinated biphenyls. In: Proceedings of the National Conference on Polychlorinated Biphenyls, p 268, Environmental Protection Agency, Publ 560–6–75–004, USERA, Washington, 1976.

    Google Scholar 

  133. Wayne EJ, Koutras DA, Alexander WD (eds.): Clinical Aspects of Iodine Metabolism, Blackwell Scientific, London, 1964.

    Google Scholar 

  134. Weetman AP, McGregor AM: Autoimmune thyroid disease: Developments in our understanding. En-docr Rev 5:309, 1984.

    CAS  Google Scholar 

  135. Windholz M (ed.), Budavari S (co-ed.), Blumetti RF, et al. (assoc. eds.): The Merck Index, 10th ed., E. Merck & Co., Rahway, NJ, 1983.

    Google Scholar 

  136. Woeber K, Ingbar SH: Antithyroid effects of noncal-origenic congeners of salicylate, with observations on the influence of serum proteins on the potency of antithyroid agents. Endocrinology 76:584, 1965.

    PubMed  CAS  Google Scholar 

  137. Wolff J, Standaert ME, Rall J: Thyroxine displacement from the serum and depression of serum protein-bound iodine by certain drugs. J Clin Invest 40:1373, 1961.

    PubMed  CAS  Google Scholar 

  138. Gaitan E: Goitrogens. Bailliere Clin Endocrinol Metab 2: 683, 1988.

    CAS  Google Scholar 

  139. Gaitan E (ed.): Environmental Goitrogenesis, CRC Press, Boca Raton, 1989.

    Google Scholar 

  140. Gaitan E: Goitrogens in food and water. Annu Rev Nutr 10:21, 1990.

    PubMed  CAS  Google Scholar 

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Gaitan, E. (1992). Disorders of the Thyroid. In: Tarcher, A.B. (eds) Principles and Practice of Environmental Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2447-6_22

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