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Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis

  • John T. Gallagher
  • Jeremy E. Turnbull
  • Malcolm Lyon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 313)

Abstract

Heparan sulphate proteoglycans (HSPGs) are normally the most abundant PG components of cell surfaces and basement membranes (1, 2). At the molecular level five core proteins have been described that can be glycanated with HS chains (2, 3) but evidence exists for several other probably distinct species including two cell surface HSPGs in which the core proteins have been shown to bind either TGF-ß (4) or fibroblast growth factor (FGF;5); the former has been named betaglycan. A recent surprising finding was that the secretory granule PG, named serglycin, which normally appears as a heparin or chondroitin sulphate PG, is synthesised as an HSPG in an erythroid cell line (6). The topographical distribution of HSPGs is therefore variable and extensive and probably reflects a broad functional spectrum to which both protein and polysaccharide components will make significant contributions (1, 2, 7).

Keywords

Heparan Sulphate Core Protein Heparan Sulphate Proteoglycan Human Lung Fibroblast Mouse Mammary Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • John T. Gallagher
    • 1
  • Jeremy E. Turnbull
    • 1
  • Malcolm Lyon
    • 1
  1. 1.Cancer Research Campaign Department of Medical OncologyChristie Hospital NHS TrustManchesterUK

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